Internal Medicine Section
DOI: 10.7860/JCDR/2016/19500.8384
Original Article
Markers of Oxidative Stress and Clinical Outcome in Critically ill Septic Patients: A Preliminary Study from North India
Mradul Kumar Daga1, Naushad Ahmad Khan2, Harpreet Singh3, Ankit Chhoda4, Sahil Mattoo5, Basant Kumar Gupta6
Introduction: Sepsis is the leading cause of mortality in noncoronary Intensive Care Units (ICUs). Oxidative stress is one of the important features in pathogenesis of sepsis. Aim: This study was undertaken to evaluate levels of oxidants and antioxidants in patients with sepsis admitted to ICU. Study Design: This was a non-interventional clinical casecontrol study undertaken at a tertiary level teaching hospital in New Delhi, India. Materials and Methods: Forty-six consecutive non-pediatric patients admitted to ICU with sepsis were included and subjected to detailed history, physical examination and investigations. Blood samples were drawn to evaluate oxidant Malondialdehyde (MDA) and antioxidant (alpha-tocopherol) levels. Acute Physiology and Chronic Health Evaluation II (APACHE II) and Organ Dysfunction and/or Infection (ODIN) scores were calculated and patients followed up for outcomes. Twenty age and sex matched healthy subjects served as controls.
Results: Mean levels of malondialdehyde were higher in patients than controls (17.2±3.8nm/ml versus 4.6±1.6nm/ml, p20 breaths per minute or PaCO2, 12,000/cumm, 10% immature (band) forms. Exclusion criteria were: age
DOI: 10.7860/JCDR/2016/19500.8384
Original Article
Markers of Oxidative Stress and Clinical Outcome in Critically ill Septic Patients: A Preliminary Study from North India
Mradul Kumar Daga1, Naushad Ahmad Khan2, Harpreet Singh3, Ankit Chhoda4, Sahil Mattoo5, Basant Kumar Gupta6
Introduction: Sepsis is the leading cause of mortality in noncoronary Intensive Care Units (ICUs). Oxidative stress is one of the important features in pathogenesis of sepsis. Aim: This study was undertaken to evaluate levels of oxidants and antioxidants in patients with sepsis admitted to ICU. Study Design: This was a non-interventional clinical casecontrol study undertaken at a tertiary level teaching hospital in New Delhi, India. Materials and Methods: Forty-six consecutive non-pediatric patients admitted to ICU with sepsis were included and subjected to detailed history, physical examination and investigations. Blood samples were drawn to evaluate oxidant Malondialdehyde (MDA) and antioxidant (alpha-tocopherol) levels. Acute Physiology and Chronic Health Evaluation II (APACHE II) and Organ Dysfunction and/or Infection (ODIN) scores were calculated and patients followed up for outcomes. Twenty age and sex matched healthy subjects served as controls.
Results: Mean levels of malondialdehyde were higher in patients than controls (17.2±3.8nm/ml versus 4.6±1.6nm/ml, p20 breaths per minute or PaCO2, 12,000/cumm, 10% immature (band) forms. Exclusion criteria were: age
