New Zealand Veterinary Journal
ISSN: 0048-0169 (Print) 1176-0710 (Online) Journal homepage: http://www.tandfonline.com/loi/tnzv20
Mannosidosis — A cause of neonatal mortality in angus calves R.D. Jolly B.V.Sc. Ph.D. M.A.C.V.Sc. & K.G. Thompson B.V.Sc. To cite this article: R.D. Jolly B.V.Sc. Ph.D. M.A.C.V.Sc. & K.G. Thompson B.V.Sc. (1976) Mannosidosis — A cause of neonatal mortality in angus calves, New Zealand Veterinary Journal, 24:8, 184-185, DOI: 10.1080/00480169.1976.34313 To link to this article: http://dx.doi.org/10.1080/00480169.1976.34313
Published online: 23 Feb 2011.
Submit your article to this journal
Article views: 8
View related articles
Citing articles: 1 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=tnzv20 Download by: [University of Pennsylvania]
Date: 05 November 2015, At: 17:58
184
NEW ZEALAND VETERINARY JOURNAL
VOL. 24
CLINICAL COMMUNICATION MANNOSIDOSIS -A CAUSE OF NEONATAL MORTALITY IN ANGUS CALVES
Downloaded by [University of Pennsylvania] at 17:58 05 November 2015
R. D. JOLLY AND K. G. THOMPSON*
MANNOSIDOSIS, a le:thal inherited neuro logical disease associated with a de ficiency of the lysosomal enzyme 0. rnannosidase (Hocking et al., 1972) has been described clinically as affectinj?; Angus calves usually in their first year of life (Whittem and Walker, 1957; Jolly, 1970, 1975). Although it has been sus pected as a significant cause of neonatal mortality in herds at risk, figures and diagnosis supporting such an hypothesis have not been available. CLINICAL AND PATHOLOGICAL HISTORY
As part of a continuing research pro ject into mannosidosis, two herds of heterozygous animals have been maintain ed. The first comprised in anyone year up to 13 obligate -heterozygous cows and a similar bull, calved in the years 1969-70 and 1970-71. The second herd was composed of 20 cows and a bull that were selected as heterozygous on the basis of having less than normal plasma levels ofa.-mannosidase (Jolly et ai., 1973b; 1974a,b) calved in the spring of 1975. Over the four breeding seasons a total of 46 calves were born of which 11 were diagnosed subsequently on pathological and biochemical evidence as having man nosidosis. No deaths occurred in the 35 normal or heterozygous offspring but 4 of the 11 calves with mannosidosis died. Of these, 2 were found dead shortly after birth. Both had breathed but had not fed or walked. The other two, which had had assisted. births, were weak and hospitaliz ed at 20 h of age when it was obvil()Us that they would not survive unless help ed. Both appeared to suffer a "dummy" syndrome, and ,had poor sucking reflexes. Force feeding and, in one calf use of *R. D. JoUy, B.V.Sc., Ph.D., M.A.C.V.Sc., K. G. Thompson, B.V.Sc., Faculty of Veterinary Science, Massey University, Palmerston North.
intravenous dextrose saline, resulted· in some initial improvement but only one calf developed a useful sucking reflex. This animal was found dead at 7 days' of age. The other calf was killed at day 5 when it was considered that it would not recover or survive much longer and be cause fresh tissues were needed for experimental purposes. It is our opinion that, without assiduous nursing and force feeding, both calves would have died within 36 hours of birth and, therefore, it is legitimate for the purpose of this exercise to regard them as neonatal deaths. All four births resulting in neo natal mortality occurred in wet weather. Analysis of the above results by the Xl test with Yates' continuity correction for small numbers, showed that the apparent disparity of deaths in the mannosidosis group was significant (x2 = 12.8; d.f.= 1; P
ISSN: 0048-0169 (Print) 1176-0710 (Online) Journal homepage: http://www.tandfonline.com/loi/tnzv20
Mannosidosis — A cause of neonatal mortality in angus calves R.D. Jolly B.V.Sc. Ph.D. M.A.C.V.Sc. & K.G. Thompson B.V.Sc. To cite this article: R.D. Jolly B.V.Sc. Ph.D. M.A.C.V.Sc. & K.G. Thompson B.V.Sc. (1976) Mannosidosis — A cause of neonatal mortality in angus calves, New Zealand Veterinary Journal, 24:8, 184-185, DOI: 10.1080/00480169.1976.34313 To link to this article: http://dx.doi.org/10.1080/00480169.1976.34313
Published online: 23 Feb 2011.
Submit your article to this journal
Article views: 8
View related articles
Citing articles: 1 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=tnzv20 Download by: [University of Pennsylvania]
Date: 05 November 2015, At: 17:58
184
NEW ZEALAND VETERINARY JOURNAL
VOL. 24
CLINICAL COMMUNICATION MANNOSIDOSIS -A CAUSE OF NEONATAL MORTALITY IN ANGUS CALVES
Downloaded by [University of Pennsylvania] at 17:58 05 November 2015
R. D. JOLLY AND K. G. THOMPSON*
MANNOSIDOSIS, a le:thal inherited neuro logical disease associated with a de ficiency of the lysosomal enzyme 0. rnannosidase (Hocking et al., 1972) has been described clinically as affectinj?; Angus calves usually in their first year of life (Whittem and Walker, 1957; Jolly, 1970, 1975). Although it has been sus pected as a significant cause of neonatal mortality in herds at risk, figures and diagnosis supporting such an hypothesis have not been available. CLINICAL AND PATHOLOGICAL HISTORY
As part of a continuing research pro ject into mannosidosis, two herds of heterozygous animals have been maintain ed. The first comprised in anyone year up to 13 obligate -heterozygous cows and a similar bull, calved in the years 1969-70 and 1970-71. The second herd was composed of 20 cows and a bull that were selected as heterozygous on the basis of having less than normal plasma levels ofa.-mannosidase (Jolly et ai., 1973b; 1974a,b) calved in the spring of 1975. Over the four breeding seasons a total of 46 calves were born of which 11 were diagnosed subsequently on pathological and biochemical evidence as having man nosidosis. No deaths occurred in the 35 normal or heterozygous offspring but 4 of the 11 calves with mannosidosis died. Of these, 2 were found dead shortly after birth. Both had breathed but had not fed or walked. The other two, which had had assisted. births, were weak and hospitaliz ed at 20 h of age when it was obvil()Us that they would not survive unless help ed. Both appeared to suffer a "dummy" syndrome, and ,had poor sucking reflexes. Force feeding and, in one calf use of *R. D. JoUy, B.V.Sc., Ph.D., M.A.C.V.Sc., K. G. Thompson, B.V.Sc., Faculty of Veterinary Science, Massey University, Palmerston North.
intravenous dextrose saline, resulted· in some initial improvement but only one calf developed a useful sucking reflex. This animal was found dead at 7 days' of age. The other calf was killed at day 5 when it was considered that it would not recover or survive much longer and be cause fresh tissues were needed for experimental purposes. It is our opinion that, without assiduous nursing and force feeding, both calves would have died within 36 hours of birth and, therefore, it is legitimate for the purpose of this exercise to regard them as neonatal deaths. All four births resulting in neo natal mortality occurred in wet weather. Analysis of the above results by the Xl test with Yates' continuity correction for small numbers, showed that the apparent disparity of deaths in the mannosidosis group was significant (x2 = 12.8; d.f.= 1; P
