Optic nerve and optic radiation in healthy adults at 3T

窑Investigation窑

Magnetic resonance diffusion tensor imaging of optic nerve and optic radiation in healthy adults at 3T

Department of Radiology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China Correspondence to: Zhi-Lan Bai. Department of Radiology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. [email protected] Received: 2013-03-22 Accepted: 2013-08-19

between male and female group. The FA, MD, 姿 椰 , 姿 彝 of

the bilateral optic radiation and the bilateral optic nerve had no obvious correlations to the age.

·CONCLUSION: DTI is sensitive to the

optic nerve and

radiation and the relevant DTI parameters of the optic nerve and radiation are established preliminarily in this study.

Abstract

· AIM:

· KEYWORDS:

To investigate the diffusion characteristics of

water of optic nerve and optic radiation in healthy adults and its related factors by diffusion tensor imaging(DTI) at

magnetic resonance imaging; diffusion

tensor imaging; optic nerve; optic radiation; fractional anisotropy; mean diffusivity DOI:10.3980/j.issn.2222-3959.2013.06.22

3T.

·METHODS: A total of 107 healthy volunteers performed head conventional MRI and bilateral optic nerve and optic radiation DTI. The primary data of DTI was processed by post -processing software of DTI studio 2.3, obtaining fractional

anisotropy

value,

mean

diffusivity

value,

principal engine value, orthogonal engine value by measuring, and analyzed by the SPSS13.0 statistical software.

·RESULTS: The bilateral optic nerve and optic radiation fibers presented green color in directional encoded color (DEC) maps and presented high signal in fractional anisotropy

(FA) maps. The FA value of the left optic

nerve was 0.598依0.069 and the right was 0.593依0.065; the mean diffusivity (MD) value of the left optic nerve was (1.324依0.349)伊10 -3mm2/s and the right was (1.312依0.350)伊 10-3mm2/s; the principal engine value (姿 椰) of the left optic nerve was

(2.297 依0.522) 伊10 -3mm2/s and the right was

(2.277依0.526)伊10-3mm2/s; the orthogonal engine value (姿 彝) of the left optic nerve was (0.838依0.285)伊10 -3mm2/s and

the right was (0.830 依0.280) 伊10 -3mm2/s; the FA value of the left optic radiation was 0.636依0.057 and the right was 0.628 依0.056; the mean diffusivity (MD) value of the left optic radiation was (0.907依0.103)伊10 -3mm2/s and the right was (0.889 依0.125) 伊10 -3mm2 /s; the principal eigenvalue (姿 椰) of the left optic radiation was (1.655依0.210)伊10 -3mm2/

s and the right was

(1.614 依0.171) 伊10

mm2/s; the

-3

orthogonal enginvalue (姿彝) of the left optic radiation was

(0.531依0.103)伊10﹣3mm2/s and the right was (0.524依0.152)伊 10 -3mm2/s. There was no obvious difference between the FA, MD, 姿 椰 , 姿 彝 of the bilateral optic radiation and the bilateral optic nerve ( 868

跃0.05) and no obvious difference

Sun HH, Wang D, Zhang QJ, Bai ZL, He P. Magnetic resonance diffusion tensor imaging of optic nerve and optic radiation in healthy adults at 3T.

2013;6(6):868-872

INTRODUCTION ptic nerve diseases are big threats to visual function, such as glaucoma (open angle or closed-angle), optic nerve neuritis, multiple sclerosis (demyelination and axonal injury), tumor and so on. Some lesions involving the visual central system can cause structural changes of the optic nerve or central visual pathways eventually leading to irreversible visual impairment, early diagnosis and treatment is particularly important. Diffusion tensor imaging (DTI) is currently the only noninvasive technique study of cerebral white matter and white matter tracts, which can measure and quantify the tissue microstructure change, providing the possibility for the early detection of visual pathway lesions. However, the large sample research for the diffusion characteristics of water of the optic nerve and the optic radiation is not at present [1]. In this study we collected 107 healthy volunteers for MR-DTI research to investigate the diffusion characteristics of water of the optic nerve and the optic radiation, which are basis for the quantitative study and early diagnosis and treatment of the optic nerve disease, providing some objectives. SUBJECTS AND METHODS Subjects Initially 115 healthy volunteers studied but due to severe image artifacts eight cases were excluded and finally 107 cases selected for our study. Fifty-six females and fifty-one males, mean age=40.27依12.49(18-62) years. Exclusion

O

陨灶贼 允 韵责澡贼澡葬造皂燥造熏 灾燥造援 6熏 晕燥援 6熏 Dec.18, 圆园13 www. IJO. cn 栽藻造押8629原愿圆圆源缘员苑圆 8629-82210956 耘皂葬蚤造押ijopress岳员远猿援糟燥皂

Figure 1 DEC map of bilateral optic nerve and radiation A: DEC map of bilateral optic nerve; B: Bilateral optic radiation. Three equal-sized ROIs in the middle of bilateral optic and bilateral optic radiation.

Figure 2 FA map of bilateral optic nerve and radiation A: FA map of bilateral optic nerve; B: Bilateral optic radiation.

criteria: 1) No history of eye diseases, intraocular surgery, optic neuropathy diseases and other diseases that affect the visual field; 2) No sellar region lesions; 3) No congenital developmental disorders; 4) Normal visual function tests such as visual field, visual acuity and color vision 5) No neurological signs and symptoms; 6) Head conventional MRI (T1WI, T2WI, FIAIR) showed no abnormality. Informed consent was taken from all the volunteers. Methods MRI examination All MR examinations were performed with a 3.0T scanner (GE Sigma HDxt), a dedicated eight-element head coil was used for radiofrequency signal transmission and reception. In the start, all the subjects were performed head conventional MRI, those subjects which were found no abnormality performed bilateral optic nerve and optic radiation DTI, diffusion tensor imaging was acquired on each patient with a single-shot echo planar imaging sequence: TR=10 600ms, TE=86ms, slice thickness=2mm, intersection gap=0, FOV=24, NEX=2, 12 directions, b=0 and 1 000s/mm3; During the scanning range though the maxillary sinus to the parietal lobe, volunteers were asked to close their eyes gently and try not to move the eyeball. Data processing The primary data of diffusion tensor imaging were processed with post-processing software of the DTI studio 2.3 (Hopkins University development) to get the directional encoded color map and the fractional anisotropy map. Fiber directions on directional encoded color (DEC) map: red=left-right; blue=superior-inferior; green=anteriorposterior. Three regions of interests (ROIs) of fixedly

approximately 5mm2 were manually drawn on the reference DEC images (Figure 1A) at the level of the middle part of the orbital optic nerve (to avoid the eye movement artifact and the effect of the posterior chiasm, the surrounding bone and gas), and then get the fractional anisotropy (FA) value on the FA map (Figure 2A), get the 姿1 value, 姿2 value and 姿3 value respectively on each map, MD= [(姿1、 姿2、 姿3)/3], 姿‖(AD)= 姿1, 姿⊥ (RD)= [(姿2+姿3)/2]; ROIs were also manually drawn on the reference DEC images (Figure 1B) at the level of the middle part of the radiation of the trigone of bilateral lateral ventricle (on this section the intuitive structure is corpus callosum and trigone of lateral ventricles, optic radiation constituting the outer side wall of the posterior horn of the lateral ventricle, presenting green ribbon thin layer running from anterior to posterior), and then get the FA value (Figure 2B), 姿‖ , 姿 ⊥ and MD value according to the above methods. 姿‖ (AD) map and 姿⊥(RD) map shown as below (Figures 3, 4)[2]. Statistical Analysis The SPSS version 13.0 statistical program was used: 1) The paired -test was used to analyze the DTI parameters of bilateral optic nerve and optic radiation; the group -test was used to assess the impact of gender on the DTI parameters; Linear correlation analysis was used to assess the association between age and the DTI parameters; 2)

Magnetic resonance diffusion tensor imaging of optic nerve and optic radiation in healthy adults at 3T.

To investigate the diffusion characteristics of water of optic nerve and optic radiation in healthy adults and its related factors by diffusion tensor...
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