RESEARCH ARTICLE

Macular Ganglion Cell Inner Plexiform Layer Thickness in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects Chunwei Zhang1,2, Andrew J. Tatham2,3, Ricardo Y. Abe2,4, Na’ama Hammel2, Akram Belghith2, Robert N. Weinreb2, Felipe A. Medeiros2, Jeffrey M. Liebmann5, Christopher A. Girkin6, Linda M. Zangwill2*

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1 Department of Ophthalmology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, 2 Hamilton Glaucoma Center, Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, San Diego, United States of America, 3 Princess Alexandra Eye Pavilion and Department of Ophthalmology, University of Edinburgh, Edinburgh, United Kingdom, 4 Department of Ophthalmology, University of Campinas, Campinas, Brazil, 5 Harkness Eye Institute, Columbia University Medical Center, New York, New York, United States of America, 6 Department of Ophthalmology, University of Alabama, Birmingham, Alabama, United States of America * [email protected]

OPEN ACCESS Citation: Zhang C, Tatham AJ, Abe RY, Hammel N, Belghith A, Weinreb RN, et al. (2016) Macular Ganglion Cell Inner Plexiform Layer Thickness in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects. PLoS ONE 11(8): e0160549. doi:10.1371/journal.pone.0160549 Editor: Rafael Linden, Universidade Federal do Rio de Janeiro, BRAZIL

Abstract Purpose To investigate macular ganglion cell–inner plexiform layer (mGCIPL) thickness in glaucomatous eyes with visible localized retinal nerve fiber layer (RNFL) defects on stereophotographs.

Received: November 17, 2015

Methods

Accepted: July 21, 2016

112 healthy and 149 glaucomatous eyes from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES) subjects had standard automated perimetry (SAP), optical coherence tomography (OCT) imaging of the macula and optic nerve head, and stereoscopic optic disc photography. Masked observers identified localized RNFL defects by grading of stereophotographs.

Published: August 18, 2016 Copyright: © 2016 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported in part by National Institutes of Health/National Eye Institute grants EY021818 (FAM), EY11008 (LMZ), EY14267 (LMZ), EY019869 (LMZ), core grant P30EY022589; NHS Scotland Career Researcher Grant (AJT); an unrestricted grant from Research to Prevent Blindness (New York, NY); grants for participants’ glaucoma medications from Alcon, Allergan, Pfizer, Merck and Santen; Natural Science Foundation of Heilongjiang Province for Returned Scholars, China.

Result 47 eyes had visible localized RNFL defects on stereophotographs. Eyes with visible localized RNFL defects had significantly thinner mGCIPL thickness compared to healthy eyes (68.3 ± 11.4 μm versus 79.2 ± 6.6 μm respectively, P

Macular Ganglion Cell Inner Plexiform Layer Thickness in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects.

To investigate macular ganglion cell-inner plexiform layer (mGCIPL) thickness in glaucomatous eyes with visible localized retinal nerve fiber layer (R...
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