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Lymphocyte Glutathione Peroxidase Activity During Exacerbations in Multiple Sclerosis PER SCHMIDT ,SORENSEN, *'1 J E N S C. HANSEN, 2 JESPER MAI,3 LENE R. NIELSEN, ~ AND TROELS SORENSEN 1
1Department of Neurology, Central Hospital, Viborg, Denmark; 2Institute of Environmental and Occupational Medicine, University of Aarhus, Aarhus, Denmark; and 3Department or" Neurology, Aarhus University Hospital, Aarhus, Denmark Received June 18, 1991; Accepted October 1, 1991
ABSTRACT Glutathione peroxidase, one of the major antioxidants in the human brain, has been found to have decreased activity in patients suffering from multiple sclerosis (MS). This study compares the activity of lymphocyte glutathione peroxidase (L-GSH-px) in MS patients suffering from acute relapses with clinically stable MS patients and with control patients referred with nondemyelinating neurological diseases. All three groups showed an increase of mean enzymatic activity (MEA) during the observation period. The highest MEA in this study was observed in the MS groups. However, there were no significant differences in the L-GSH-px activity in the three groups. These results are not in accordance with previous investigations, and the need for further research in this field is emphasized. Index Entries: Multiple sclerosis; MS attacks; glutathione perox-
idase; selenium. *Author to whom all correspondence and reprint requests should be addressed.
Biological Trace Element Research
] 45
Vol. 33, 1992
146
Sorensen et al.
INTRODUCTION The selenium-containing enzyme glutathione peroxidase is one of the major antioxidants in the human brain. Since 1975, lipid peroxidation was proposed as a pathogenetic factor in multiple sclerosis (MS) (I0), antioxidant activity and, thus, selenium and glutathione peroxidase activity in this disease have achieved much interest. The mean whole blood selenium content (wbs) in MS patients as well as in humans not suffering from this disease, has been found to be
Lymphocyte Glutathione Peroxidase Activity During Exacerbations in Multiple Sclerosis PER SCHMIDT ,SORENSEN, *'1 J E N S C. HANSEN, 2 JESPER MAI,3 LENE R. NIELSEN, ~ AND TROELS SORENSEN 1
1Department of Neurology, Central Hospital, Viborg, Denmark; 2Institute of Environmental and Occupational Medicine, University of Aarhus, Aarhus, Denmark; and 3Department or" Neurology, Aarhus University Hospital, Aarhus, Denmark Received June 18, 1991; Accepted October 1, 1991
ABSTRACT Glutathione peroxidase, one of the major antioxidants in the human brain, has been found to have decreased activity in patients suffering from multiple sclerosis (MS). This study compares the activity of lymphocyte glutathione peroxidase (L-GSH-px) in MS patients suffering from acute relapses with clinically stable MS patients and with control patients referred with nondemyelinating neurological diseases. All three groups showed an increase of mean enzymatic activity (MEA) during the observation period. The highest MEA in this study was observed in the MS groups. However, there were no significant differences in the L-GSH-px activity in the three groups. These results are not in accordance with previous investigations, and the need for further research in this field is emphasized. Index Entries: Multiple sclerosis; MS attacks; glutathione perox-
idase; selenium. *Author to whom all correspondence and reprint requests should be addressed.
Biological Trace Element Research
] 45
Vol. 33, 1992
146
Sorensen et al.
INTRODUCTION The selenium-containing enzyme glutathione peroxidase is one of the major antioxidants in the human brain. Since 1975, lipid peroxidation was proposed as a pathogenetic factor in multiple sclerosis (MS) (I0), antioxidant activity and, thus, selenium and glutathione peroxidase activity in this disease have achieved much interest. The mean whole blood selenium content (wbs) in MS patients as well as in humans not suffering from this disease, has been found to be
![[Treatment of multiple sclerosis symptoms and exacerbations].](/assets/img/hold.png)
