Lymphangiomyomatosis in the Atlantic Bottlenose Dolphin (Tursiops truncatus) Author(s): Arnold J. Rawson, M.D., Geoffrey W. Patton, B.S., John S.J. Brooks, M.D. Source: Journal of Wildlife Diseases, 28(2):323-325. Published By: Wildlife Disease Association DOI: http://dx.doi.org/10.7589/0090-3558-28.2.323 URL: http://www.bioone.org/doi/full/10.7589/0090-3558-28.2.323

BioOne (www.bioone.org) is a nonprofit, online aggregation of core research in the biological, ecological, and environmental sciences. BioOne provides a sustainable online platform for over 170 journals and books published by nonprofit societies, associations, museums, institutions, and presses. Your use of this PDF, the BioOne Web site, and all posted and associated content indicates your acceptance of BioOne’s Terms of Use, available at www.bioone.org/page/terms_of_use. Usage of BioOne content is strictly limited to personal, educational, and non-commercial use. Commercial inquiries or rights and permissions requests should be directed to the individual publisher as copyright holder.

BioOne sees sustainable scholarly publishing as an inherently collaborative enterprise connecting authors, nonprofit publishers, academic institutions, research libraries, and research funders in the common goal of maximizing access to critical research.

Journal

of Wildlife

Diseases,

Lymphangiomyomatosis (Tursiops

in the Atlantic

M.D.,’

Arnold J. Rawson,

The

ABSTRACT:

a

Geoffrey

first

in a marine

stranded

male

( Tursiops

disease

diastinal have

of lymphangiomyis reported

Atlantic

been

bottlenose This

this

of

lymph

of testosterone

ported

cases

females. Key dolphin, terone,

words: Tursiops truncatus, lymphangiomyomatosis, first case, case report.

phangio!eiom

yomatosis)

mon non-malignant proliferative process, case studies have been (Enzinger and Weiss, composed muscle nary

is an

lymph

vessels

parenchymal

nodes,

and

lymph

nodes

masses

and may

as

involve

as well.

The

is

involvement

may

fuse.

Affected

individuals

dyspnea

and

effusion cases

often

The

smooth

collection

muscle

in

1988),

ceptors on the (Brentani Exposure

for both estrogen smooth muscle et a!., 1984; to estrogens

sion as

of the

and

lesion

ovaniectomy,

one administration (McCarty et a!.,

1984).

females

Weiss,

or

studies

(sleek

dif-

ter

pleura! and

shown

who

building

went

(27#{176}10’35”N, 82#{176}29’50”W). saw the animal wash into into the water and moved

and

shore while authorities.

treatment.

animal

exhibited

with

only

slightly

foul

of brown

nasal

attempt)

and

and

bony

superficial breath,

exudate mild

small (1.0 cm). Respirations were regular and averaged 1 to 3/mm with a heart nate of 66 bpm. The dolphin was physiologically stabilized through rehydration and medication. Af-

with

(Enzinger

Key

abrasions amounts

intractable

et a!.,

been

was

retroperitonea!

nodular

re-

dolphin (Tursiops truncatus) As Tropical Storm Marco

evaluation

lymph

present

with

(Graham have

be

previous mammals. of lymphanbottlenose

pulmo-

cells are arranged about endothelium-lined spaces. Foci of lymphocytes and hemosidenin deposits may be seen throughout (Enzingen and Weiss, 1988). Involved lungs show evidence of bronchial obstruction. The

no

The animal was transported by stranding network personnel to Mote Marine Laboratory (Sarasota, Florida 34236, USA) and was placed in a natural seawater tank for

of smooth

mediastinal

contains

the animal to a nearby sandy another person went to notify

uncom-

within

literature

‘Mote Marine Laboratory, 1600 Laboratory Medicine, University

port of this !esion in marine Hence, the following report giomyomatosis in the Atlantic

on Casey A beachgoer the rocks

but life-threatening of which numerous reported in humans 1988). The lesion

of proliferating and

known

and

off Florida’s west coast the evening of 10 October 1990, a 295 cm, 193 kg male do!phin was found alive at a rocky gulf shore

bottlenose lung, testos-

(also

Lymphangiomyomatosis !ym

me-

nodes.

may significant since all redisease in humans occur in

pathologically

level

pro!if-

the

and

M.D.,2

of Pathology

The

dolphin

lungs

mesenteric

low

John S.J. Brooks,

from

progressive

the

probably

An extraordinarily

B.S.,’

case

involved

and

W. Patton,

florida 34236, USA; 2 Department Pennsylvania 19104, USA

mammal

truncatus).

erative

Dolphin

truncatus)

Thompson Parkway, Sarasota, of Pennsylvania, Philadelphia,

omatosis

Bottlenose

1992. pp. 323-325 Association 1992

28(2), Disease

© Wildlife

re-

and progesterone cells of the lesions Co!ley et a!., 1989). speeds the progres-

ing mal

an examination died and was

the

following

was

taking

food

day five, it was dedolphin to another recuperation. Dur-

on day examined

nine, the post-mortem

ani-

day.

At necropsy the lungs were described as !umpy and somewhat hard to cut. Lange firm areas suggestive of neoplasm were present and scattered cystic change was seen in the surrounding parenchyma. On

(Shen et al., 1987), whereand especially progesterpermit regression 1980).

section 323

the

firm

areas

consisted

of

uni-

JOURNAL

324

OF WILDLIFE

DISEASES,

VOL.

28, NO.

2, APRIL

1992

..1

,..

..-

-

.

FIGURE

.

1.

bottlenose showing

Section

dilated

surrounded 320

of a lung

dolphin by

with lymphatic

smooth

nodule

in an

Atlantic

channels muscle

of

various

bundles.

2.

FIGURE

bottlenose

lymphangiomyomatosis H&E.

sizes Bar

showing

smooth

lymphatic the

sm.

pale grayish were large dark

tissue, throughout foci, which proved

on microscopy Mediastina!

to be hemosiderin lymph nodes measured

in diameter firm grayish

and were composed tissue with dark

deposits.

Mesenteric

lymph

sured grossly

3 cm in diameter. normal; testicular

saved seen growth

for microscopy. in the other layer groups

and

in relation of small

scattered

Bar

in an

Atlantic to dilated

lymphocytes

lymphocytes

in in

the

80 sm.

firm areas, replaced.

lung There

parenchyma was were numerous

nodes

their

(Armed Washington, Number

3). In histologic

of lung

mea-

appeared was not

this animal specimens the Registry

Comparative Pathology Institute of Pathology, 20306, USA; Accession sections

the pale entirely

nodules clusters

interstitium

nodule

lymphangiomyomatosis

of similar hemosidenin

No abnormality organs. Counting (GLG) in the

(Hohn et a!., 1989) showed >20-yr-old. Representative this lesion were sent to

muscle

H&E.

lung

short fasciculi of smooth musc!e throughout. The muscle bundles were distinguished from collagen by means of the Masson Trichrome stain (Masson, 1929) and

Testes tissue

deposits. 4 cm

of

with

channels,

channel.

formly which

Section

dolphin

was of teeth was of of

Forces D.C. 2304654taken

from

nature

was

positive reaction muno-peroxidase Hrapchak, formed

confirmed

In some

1987).

small

by

for desmin technique nodular

means

of a

using the (Sheehan

imand

areas aggregates,

the

muscle while

elsewhere it surrounded small endothelium-lined vascular channels which contained proteinaceous fluid and occasional lymphocytes but no red blood cells. Between these channels ies filled with red foci were

were blood capillarblood cells. Numerous

of lymphocytes and scattered throughout

of hemosidenin the tissue (Figs.

SHORT

1, 2). In the lung parenchyma nipheny of the lesions were many dilated there

was

bronchi. patchy

at the pecystical!y

Elsewhere in the acute bronchopneumo-

lung

nia.

vived

and

the

amination.

COMMUNICATiONS

subsequent

We

325

post-mortem

particularly

asota Memorial Hospital Pathology Laboratory for

ex-

thank

the

and

Sarasota the lab

help

with

San-

analyses. Sections

vealed

mediastinal little remaining

of

very

structure.

The

placed

by

sels,

node

musc!e

was

similar of the

areas node, served.

the

and

to those lung. In

node However,

nodes relymph node

almost

fascicu!i,

lymphocytes,

posits

lymph

tota!ly

lymphatic hemosiderin

seen in the a mesentenic

structure there

was was

largely a focal

crease in smooth muscle surrounding phatic vessels, suggestive of involvement. Hormonal assays performed on serum

collected

the

first

estrogen

Lymphangiomyomatosis in the Atlantic bottlenose dolphin (Tursiops truncatus).

The first case of lymphangiomyomatosis in a marine mammal is reported from a stranded male Atlantic bottlenose dolphin (Tursiops truncatus). This prog...
492KB Sizes 0 Downloads 0 Views