HHS Public Access Author manuscript Author Manuscript
Am Surg. Author manuscript; available in PMC 2015 March 17. Published in final edited form as: Am Surg. 2014 May ; 80(5): 505–510.
Lower Vitamin D Levels in Surgical Hyperparathyroidism versus Thyroid Patients BRENESSA M. LINDEMAN, M.D.*, CATHERINE E. PESCE, M.D.*, HUA-LING TSAI, M.S.†, HELINA SOMERVELL, C.R.N.P.*, CHRISTOPHER B. UMBRICHT, M.D., Ph.D.*,‡,§, JEANNE KOWALSKI, Ph.D.†, and MARTHA A. ZEIGER, M.D.*,‡
Author Manuscript
*Department
of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland of Biostatistics, The Johns Hopkins University School of Medicine, Baltimore, ‡ Maryland Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland §Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland †Department
Abstract
Author Manuscript Author Manuscript
Low vitamin D levels have been shown to be associated with primary hyperparathyroidism, but it is unclear whether vitamin D deficiency may be an etiologic factor in the development of primary hyperparathyroidism. To investigate this, we compared preoperative vitamin D levels of patients undergoing surgery for primary hyperparathyroidism with those of patients undergoing surgery for benign thyroid disease. With Institutional Review Board approval, data were collected prospectively on patients undergoing parathyroidectomy or thyroidectomy by one surgeon between March 2006 and July 2011. Patients were excluded if they underwent simultaneous thyroid and parathyroid surgery, had secondary or tertiary hyperparathyroidism, if no preoperative vitamin D level was measured, or if they took vitamin D supplements. Inclusion criteria were met by 219 patients who underwent parathyroidectomy and 186 patients who underwent thyroid surgery. Patient age, sex, race, and preoperative vitamin D levels (vitamin D 25-OH; normal, 32 to 100 pg/mL) were collected. Statistical analysis was performed using linear regression. Vitamin D levels were significantly lower in the parathyroid group compared with the thyroid group (23.8 vs 28.5 pg/mL; P
Am Surg. Author manuscript; available in PMC 2015 March 17. Published in final edited form as: Am Surg. 2014 May ; 80(5): 505–510.
Lower Vitamin D Levels in Surgical Hyperparathyroidism versus Thyroid Patients BRENESSA M. LINDEMAN, M.D.*, CATHERINE E. PESCE, M.D.*, HUA-LING TSAI, M.S.†, HELINA SOMERVELL, C.R.N.P.*, CHRISTOPHER B. UMBRICHT, M.D., Ph.D.*,‡,§, JEANNE KOWALSKI, Ph.D.†, and MARTHA A. ZEIGER, M.D.*,‡
Author Manuscript
*Department
of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland of Biostatistics, The Johns Hopkins University School of Medicine, Baltimore, ‡ Maryland Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland §Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland †Department
Abstract
Author Manuscript Author Manuscript
Low vitamin D levels have been shown to be associated with primary hyperparathyroidism, but it is unclear whether vitamin D deficiency may be an etiologic factor in the development of primary hyperparathyroidism. To investigate this, we compared preoperative vitamin D levels of patients undergoing surgery for primary hyperparathyroidism with those of patients undergoing surgery for benign thyroid disease. With Institutional Review Board approval, data were collected prospectively on patients undergoing parathyroidectomy or thyroidectomy by one surgeon between March 2006 and July 2011. Patients were excluded if they underwent simultaneous thyroid and parathyroid surgery, had secondary or tertiary hyperparathyroidism, if no preoperative vitamin D level was measured, or if they took vitamin D supplements. Inclusion criteria were met by 219 patients who underwent parathyroidectomy and 186 patients who underwent thyroid surgery. Patient age, sex, race, and preoperative vitamin D levels (vitamin D 25-OH; normal, 32 to 100 pg/mL) were collected. Statistical analysis was performed using linear regression. Vitamin D levels were significantly lower in the parathyroid group compared with the thyroid group (23.8 vs 28.5 pg/mL; P
