Low Platelet Adhesiveness and Other Hemostatic Abnormalities in Hypothyroidism J . ROGER EDSON, M.D., DENNIS R. FECHER, M.D., and RICHARD P. DOE, M.D., Ph.D., Minneapolis, Minnesota, and Fort Smith, Arkansas

Fifteen patients with definite hypothyroidism and two with probable hypothyroidism had extensive hemostatic profiles done. In 12 of the 16 patients tested, the platelet adhesiveness (platelet retention in a glass bead column) was abnormal, and in 1 more it was borderline. In the six patients who were studied repeatedly, hemostatic abnormalities either markedly improved or disappeared after treatment with L-thyroxine. It is concluded that, in addition to the previously reported coagulation factor deficiencies (which we also observed in some of our patients), low platelet adhesiveness occurs frequently in patients with hypothyroidism.

of the definitely hypothyroid patients by serum thyroxine (T4) levels, and in some of these by finding elevated serum thyrotrophin (TSH) levels as well. Patient 1, who was studied 6 weeks after total thyroidectomy, did not have thyroid function tests done. Patient 7 was found to be severely hypothyroid Wi years after platelet function tests were done. Of the two probable hypothyroid patients, one had a borderline elevated TSH value 5 years after treatment with antithyroid drugs for hyperthyroidism. The other had a history and physical findings consistent with hypothyroidism, a normal T

Low platelet adhesiveness and other hemostatic abnormalities in hypothyroidism.

Fifteen patients with definite hypothyroidism and two with probable hypothyroidism had extensive hemostatic profiles done. In 12 of the 16 patients te...
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