0021-972X/91/7202-0301$03.00/0 Journal of Clinical Endocrinology and Metabolism Copyright© 1991 by The Endocrine Society
Vol. 72, No. 2 Printed in U.S.A.
Low Growth Hormone Levels Are Related to Increased Body Mass Index and Do not Reflect Impaired Growth in Luteinizing Hormone-Releasing Hormone AgonistTreated Children with Precocious Puberty GERDINE A. KAMP*, PENELOPE K. MANASCO, KEVIN M. BARNES, JANET JONES, SUSAN R. ROSE, SUVIMOL C. HILL, AND GORDON B. CUTLER, JR. Developmental Endocrinology Branch, National Institute of Child Health and Human Development, the Clinical Center (J.J., S.C.H.), National Institutes of Health, Bethesda, Maryland 20892; and the Laboratory of Molecular and Integrative Neurosciences, National Institute of Environmental Health Sciences, National Institutes of Health (P.K.M.), Research Triangle Park, North Carolina 22709
ABSTRACT. To test the hypothesis that GH deficiency might explain the low growth velocity of some LHRH agonist (LHRHa)-treated children with central precocious puberty, we measured stimulated (n = 81) and spontaneous (n = 32) GH levels during or after LHRHa treatment. GH stimulation tests in the children who were receiving LHRHa treatment were performed after 2 days of ethinyl estradiol administration. Thirty-one of 81 children (38%) who underwent GH stimulation tests had subnormal responses (
Vol. 72, No. 2 Printed in U.S.A.
Low Growth Hormone Levels Are Related to Increased Body Mass Index and Do not Reflect Impaired Growth in Luteinizing Hormone-Releasing Hormone AgonistTreated Children with Precocious Puberty GERDINE A. KAMP*, PENELOPE K. MANASCO, KEVIN M. BARNES, JANET JONES, SUSAN R. ROSE, SUVIMOL C. HILL, AND GORDON B. CUTLER, JR. Developmental Endocrinology Branch, National Institute of Child Health and Human Development, the Clinical Center (J.J., S.C.H.), National Institutes of Health, Bethesda, Maryland 20892; and the Laboratory of Molecular and Integrative Neurosciences, National Institute of Environmental Health Sciences, National Institutes of Health (P.K.M.), Research Triangle Park, North Carolina 22709
ABSTRACT. To test the hypothesis that GH deficiency might explain the low growth velocity of some LHRH agonist (LHRHa)-treated children with central precocious puberty, we measured stimulated (n = 81) and spontaneous (n = 32) GH levels during or after LHRHa treatment. GH stimulation tests in the children who were receiving LHRHa treatment were performed after 2 days of ethinyl estradiol administration. Thirty-one of 81 children (38%) who underwent GH stimulation tests had subnormal responses (
