Author's Accepted Manuscript Low detectable PSA after radical prostatectomy: treat or watch? Dmitry Koulikov , Maura C. Mohler , Diana C. Mehedint , Kristopher Attwood , Gregory E. Wilding , James L. Mohler
PII: DOI: Reference:
S0022-5347(14)03620-9 10.1016/j.juro.2014.05.088 JURO 11510
To appear in: The Journal of Urology Accepted Date: 13 May 2014 Please cite this article as: Koulikov D, Mohler MC, Mehedint DC, Attwood K, Wilding GE, Mohler JL, Low detectable PSA after radical prostatectomy: treat or watch?, The Journal of Urology® (2014), doi: 10.1016/j.juro.2014.05.088. DISCLAIMER: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our subscribers we are providing this early version of the article. The paper will be copy edited and typeset, and proof will be reviewed before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to The Journal pertain. All press releases and the articles they feature are under strict embargo until uncorrected proof of the article becomes available online. We will provide journalists and editors with full-text copies of the articles in question prior to the embargo date so that stories can be adequately researched and written. The standard embargo time is 12:01 AM ET on that date.
ACCEPTED MANUSCRIPT
Low detectable PSA after radical prostatectomy: treat or watch?
RI PT
Dmitry Koulikov a, Maura C. Mohler a, Diana C. Mehedint a, Kristopher Attwood b, Gregory E. Wilding b and James L. Mohler a
No research funding provided.
M AN U
Word Count Abstract: 250 Manuscript Text: 2325
TE D
Corresponding Author: James L. Mohler, M.D. Department of Urology Roswell Park Cancer Institute Elm and Carlton Streets Buffalo, New York 14263 Telephone: (716) 845-8433 FAX: (716) 845-3300 E-mail: [email protected]
SC
a Department of Urology, Roswell Park Cancer Institute, Buffalo, New York b Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, New York
EP
Running Head: Low detectable PSA
AC C
Key words: Low detectable PSA, biochemical recurrence, radical prostatectomy
ACCEPTED MANUSCRIPT
Purpose: To determine whether the pattern of low detectable prostate-specific antigen (PSA)
RI PT
during the first 3 years of follow-up after radical prostatectomy (RP) is a predictor for subsequent biochemical recurrence (BCR).
Materials and Methods: An institutional database was queried to identify 1136 patients who
SC
underwent open retropubic RP (ORP) or robot-assisted RP (RARP) 1/5/1993 - 12/29/2008. After applying exclusion criteria, serum PSA and pattern during the first 3 years of follow-up were
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used to separate 566 men into 3 groups: 1) undetectable PSA (UD; PSA ≤0.03 ng/ml); 2) low detectable stable PSA (LD-Stable; PSA >0.03 and pT2 Pathological Gleason, no (%) 7 Surgical margins, no (%) Negative Positive unknown Follow-up, median (range) months
419 (74) 60 (60, 39-74)
93 (16) 58 (58, 41-78)
54 (10) 58 (57, 44-77)
217 (52) 202 (48) 6.4 (5.4)
23 (25) 70 (75) 6(5.4)
18 (33) 36 (67) 7.6 (5.6)
76 (18) 304 (72) 39 (9)
23 (25) 63 (68) 7 (7)
6 (11) 40 (74) 8 (15)
4 (1) 265 (65) 140 (34) 10
48 (53) 43 (47) 2
p-value
566 60 (60, 39-78)
0.003
PII: DOI: Reference:
S0022-5347(14)03620-9 10.1016/j.juro.2014.05.088 JURO 11510
To appear in: The Journal of Urology Accepted Date: 13 May 2014 Please cite this article as: Koulikov D, Mohler MC, Mehedint DC, Attwood K, Wilding GE, Mohler JL, Low detectable PSA after radical prostatectomy: treat or watch?, The Journal of Urology® (2014), doi: 10.1016/j.juro.2014.05.088. DISCLAIMER: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our subscribers we are providing this early version of the article. The paper will be copy edited and typeset, and proof will be reviewed before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to The Journal pertain. All press releases and the articles they feature are under strict embargo until uncorrected proof of the article becomes available online. We will provide journalists and editors with full-text copies of the articles in question prior to the embargo date so that stories can be adequately researched and written. The standard embargo time is 12:01 AM ET on that date.
ACCEPTED MANUSCRIPT
Low detectable PSA after radical prostatectomy: treat or watch?
RI PT
Dmitry Koulikov a, Maura C. Mohler a, Diana C. Mehedint a, Kristopher Attwood b, Gregory E. Wilding b and James L. Mohler a
No research funding provided.
M AN U
Word Count Abstract: 250 Manuscript Text: 2325
TE D
Corresponding Author: James L. Mohler, M.D. Department of Urology Roswell Park Cancer Institute Elm and Carlton Streets Buffalo, New York 14263 Telephone: (716) 845-8433 FAX: (716) 845-3300 E-mail: [email protected]
SC
a Department of Urology, Roswell Park Cancer Institute, Buffalo, New York b Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, New York
EP
Running Head: Low detectable PSA
AC C
Key words: Low detectable PSA, biochemical recurrence, radical prostatectomy
ACCEPTED MANUSCRIPT
Purpose: To determine whether the pattern of low detectable prostate-specific antigen (PSA)
RI PT
during the first 3 years of follow-up after radical prostatectomy (RP) is a predictor for subsequent biochemical recurrence (BCR).
Materials and Methods: An institutional database was queried to identify 1136 patients who
SC
underwent open retropubic RP (ORP) or robot-assisted RP (RARP) 1/5/1993 - 12/29/2008. After applying exclusion criteria, serum PSA and pattern during the first 3 years of follow-up were
M AN U
used to separate 566 men into 3 groups: 1) undetectable PSA (UD; PSA ≤0.03 ng/ml); 2) low detectable stable PSA (LD-Stable; PSA >0.03 and pT2 Pathological Gleason, no (%) 7 Surgical margins, no (%) Negative Positive unknown Follow-up, median (range) months
419 (74) 60 (60, 39-74)
93 (16) 58 (58, 41-78)
54 (10) 58 (57, 44-77)
217 (52) 202 (48) 6.4 (5.4)
23 (25) 70 (75) 6(5.4)
18 (33) 36 (67) 7.6 (5.6)
76 (18) 304 (72) 39 (9)
23 (25) 63 (68) 7 (7)
6 (11) 40 (74) 8 (15)
4 (1) 265 (65) 140 (34) 10
48 (53) 43 (47) 2
p-value
566 60 (60, 39-78)
0.003
