Journals of Gerontology: MEDICAL SCIENCES, 2015, 757–763 doi:10.1093/gerona/glu184 Research Article Advance Access publication October 18, 2014

Research Article

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Low 25-Hydroxyvitamin D Concentrations Predict Incident Depression in Well-Functioning Older Adults: The Health, Aging, and Body Composition Study Julie A. Williams,1 Kaycee M. Sink,1 Janet A. Tooze,2 Hal H. Atkinson,1 Jane A. Cauley,3 Kristine Yaffe,4 Frances A. Tylavsky,5 Susan M. Rubin,6 Eleanor M. Simonsick,7 Stephen B. Kritchevsky,1 and Denise K. Houston1 Department of Internal Medicine—Gerontology and Geriatric Medicine and 2Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina. 3Department of Epidemiology, University of Pittsburgh, Pennsylvania. 4Department of Psychiatry, University of California, San Francisco. 5 Department of Biostatistics and Epidemiology, University of Tennessee Health Sciences, Memphis. 6Department of Epidemiology and Biostatistics, University of California, San Francisco. 7National Institute of Aging, Baltimore, Maryland. 1

Address correspondence to Julie A.  Williams, MD, Sticht Center on Aging, Department of Internal Medicine—Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. Email: [email protected]

Abstract Background.  Cross-sectional studies suggest that low 25-hydroxyvitamin D (25[OH]D) may be a risk factor for depression; however, there are few prospective studies. We examined the association between 25(OH)D and depressive symptoms in community-dwelling persons aged 70–79 years in the Health, Aging, and Body Composition (Health ABC) Study (n = 2598). Methods.  Depressive symptoms were assessed using the Center for Epidemiologic StudiesDepression Scale (CES-D) at baseline and 2-, 3- and 4-year follow-up. Serum 25(OH)D was measured at 1-year follow-up and categorized as

Low 25-hydroxyvitamin D concentrations predict incident depression in well-functioning older adults: the health, aging, and body composition study.

Cross-sectional studies suggest that low 25-hydroxyvitamin D (25[OH]D) may be a risk factor for depression; however, there are few prospective studies...
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