RESEARCH ARTICLE

Longitudinal Associations between Physical and Cognitive Performance among Community-Dwelling Older Adults Magdalena I. Tolea1*, John C. Morris2, James E. Galvin1 1 Alzheimer’s Disease Research Center, Departments of Neurology, Psychiatry, and Population Health, New York University School of Medicine, New York, NY, United States of America, 2 Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University, St. Louis, MO, United States of America * [email protected]

Abstract OPEN ACCESS Citation: Tolea MI, Morris JC, Galvin JE (2015) Longitudinal Associations between Physical and Cognitive Performance among Community-Dwelling Older Adults. PLoS ONE 10(4): e0122878. doi:10.1371/journal.pone.0122878 Academic Editor: Sonia Brucki, University Of São Paulo, BRAZIL Received: September 18, 2014 Accepted: February 24, 2015 Published: April 13, 2015 Copyright: © 2015 Tolea et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: The data was collected as part of a longitudinal study at Washington University School of Medicine supported by grants from NIH (P01 AG03991 and P50 AG05681). All data is owned by the Washington University School of Medicine and kept at Washington University. Data requests can be directly made to John Morris at Washington University ( [email protected]). If approved, a minimal dataset of the de-identified variables (demographics, cognitive and physical scores) used in this project to replicate this study would be made available to the requestor. This process is in place to assure that the parent grants

To assess the directionality of the association between physical and cognitive decline in later life, we compared patterns of decline in performance across groups defined by baseline presence of cognitive and/or physical impairment [none (n = 217); physical only (n = 169); cognitive only (n = 158), or both (n = 220)] in a large sample of participants in a cognitive aging study at the Knight Alzheimer’s Disease Research Center at Washington University in St. Louis who were followed for up to 8 years (3,079 observations). Rates of decline reached 20% for physical performance and varied across cognitive tests (global, memory, speed, executive function, and visuospatial skills). We found that physical decline was better predicted by baseline cognitive impairment (slope = -1.22, p

Longitudinal associations between physical and cognitive performance among community-dwelling older adults.

To assess the directionality of the association between physical and cognitive decline in later life, we compared patterns of decline in performance a...
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