HHS Public Access Author manuscript Author Manuscript
Surgery. Author manuscript; available in PMC 2017 July 01. Published in final edited form as: Surgery. 2016 July ; 160(1): 67–73. doi:10.1016/j.surg.2016.02.029.
Long-term Oncological Outcomes for Simultaneous Resection of Synchronous Metastatic Liver and Primary Colorectal Cancer Gerd R. Silberhumer, MD1,2, Philip B. Paty, MD1, Brian Denton4, Jose Guillem, MD1, Mithat Gonen, MD4, Raphael L. C. Araujo, MD3, Garret M. Nash, MD1, Larissa K. Temple, MD1, Peter J. Allen, MD3, Ronald P. DeMatteo, MD3, Martin R. Weiser, MD1, W Douglas Wong, MD1, William R. Jarnagin, MD3, Michael I. D'Angelica, MD3, and Yuman Fong, MD3
Author Manuscript
1Department
of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, NY, NY,
USA 2Medical
University Vienna, Department of Surgery, Vienna, Austria
3Department
of Surgery, Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, NY, NY,
USA 4Department
of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, NY,
USA
Abstract Author Manuscript
Background—Twenty-five percent of patients with colorectal cancer present with simultaneous liver metastasis. Complete resection is the only potential curative treatment. Due to improvements in surgical and perioperative management, simultaneous liver and colon resections are an accepted procedure at specialized centers for selected patients. Nevertheless, little is known about the longterm oncological results of simultaneous surgical procedures compared to those of staged surgery. Patients and Methods—Patients with colorectal cancer with simultaneous liver metastases presenting for complete resection at a tertiary cancer center were identified. Patients who received the primary colon resection at an outside institution were excluded from analyses.
Author Manuscript
Results—Between 1984 and 2008, 429 patients underwent surgical treatment for colorectal cancer with simultaneous liver metastasis. Of these patients, 320 (75%) had simultaneous resection, and 109 had staged resection. There was no difference in the distribution of primary tumor locations between the 2 groups. Mean hepatic metastases size was significantly larger in the staged group (median 4 vs. 2.5cm; p
Surgery. Author manuscript; available in PMC 2017 July 01. Published in final edited form as: Surgery. 2016 July ; 160(1): 67–73. doi:10.1016/j.surg.2016.02.029.
Long-term Oncological Outcomes for Simultaneous Resection of Synchronous Metastatic Liver and Primary Colorectal Cancer Gerd R. Silberhumer, MD1,2, Philip B. Paty, MD1, Brian Denton4, Jose Guillem, MD1, Mithat Gonen, MD4, Raphael L. C. Araujo, MD3, Garret M. Nash, MD1, Larissa K. Temple, MD1, Peter J. Allen, MD3, Ronald P. DeMatteo, MD3, Martin R. Weiser, MD1, W Douglas Wong, MD1, William R. Jarnagin, MD3, Michael I. D'Angelica, MD3, and Yuman Fong, MD3
Author Manuscript
1Department
of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, NY, NY,
USA 2Medical
University Vienna, Department of Surgery, Vienna, Austria
3Department
of Surgery, Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, NY, NY,
USA 4Department
of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, NY,
USA
Abstract Author Manuscript
Background—Twenty-five percent of patients with colorectal cancer present with simultaneous liver metastasis. Complete resection is the only potential curative treatment. Due to improvements in surgical and perioperative management, simultaneous liver and colon resections are an accepted procedure at specialized centers for selected patients. Nevertheless, little is known about the longterm oncological results of simultaneous surgical procedures compared to those of staged surgery. Patients and Methods—Patients with colorectal cancer with simultaneous liver metastases presenting for complete resection at a tertiary cancer center were identified. Patients who received the primary colon resection at an outside institution were excluded from analyses.
Author Manuscript
Results—Between 1984 and 2008, 429 patients underwent surgical treatment for colorectal cancer with simultaneous liver metastasis. Of these patients, 320 (75%) had simultaneous resection, and 109 had staged resection. There was no difference in the distribution of primary tumor locations between the 2 groups. Mean hepatic metastases size was significantly larger in the staged group (median 4 vs. 2.5cm; p
