Acta Pædiatrica ISSN 0803-5253
REGULAR ARTICLE
Long-term alpha-tocopherol supplements may improve mental development in extremely low birthweight infants Hiroyuki Kitajima ([email protected])1, Tadahiro Kanazawa2, Rintaro Mori3, Shinya Hirano1, Tohru Ogihara4, Masanori Fujimura1 1.Department 2.Department 3.Department 4.Department
of of of of
Neonatal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan Comparative and Developmental Psychology, School of Human Science Osaka University, Suita, Japan Health Policy, National Center for Child Health and Development, Tokyo, Japan Pediatrics, Osaka Medical College, Takatsuki, Japan
Keywords Alpha-tocopherol, Extremely low birthweight, Mental development, Synapse elimination, Vitamin E deficiency Correspondence Hiroyuki Kitajima, MD, PhD, Department of Neonatal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho Izumi, Osaka 594-1101, Japan. Tel: +81-725-56-1220 | Fax: +81-725-56-5682 | Email: [email protected] Received 5 April 2014; revised 10 September 2014; accepted 4 November 2014. DOI:10.1111/apa.12854 Presented in part at the annual meeting of the Pediatric Academic Societies, 5–8 May 2007, Toronto, Canada.
ABSTRACT Aim: Methods to improve the mental development of extremely low birthweight (ELBW) children are currently lacking. We assessed the effects of long-term supplementation of alpha-tocopherol on the neurological development of 259 school-aged ELBW children. Methods: Extremely low birthweight participants were divided into three groups: group A with no alpha-tocopherol supplementation (n = 121); group B with the supplementation for
REGULAR ARTICLE
Long-term alpha-tocopherol supplements may improve mental development in extremely low birthweight infants Hiroyuki Kitajima ([email protected])1, Tadahiro Kanazawa2, Rintaro Mori3, Shinya Hirano1, Tohru Ogihara4, Masanori Fujimura1 1.Department 2.Department 3.Department 4.Department
of of of of
Neonatal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan Comparative and Developmental Psychology, School of Human Science Osaka University, Suita, Japan Health Policy, National Center for Child Health and Development, Tokyo, Japan Pediatrics, Osaka Medical College, Takatsuki, Japan
Keywords Alpha-tocopherol, Extremely low birthweight, Mental development, Synapse elimination, Vitamin E deficiency Correspondence Hiroyuki Kitajima, MD, PhD, Department of Neonatal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho Izumi, Osaka 594-1101, Japan. Tel: +81-725-56-1220 | Fax: +81-725-56-5682 | Email: [email protected] Received 5 April 2014; revised 10 September 2014; accepted 4 November 2014. DOI:10.1111/apa.12854 Presented in part at the annual meeting of the Pediatric Academic Societies, 5–8 May 2007, Toronto, Canada.
ABSTRACT Aim: Methods to improve the mental development of extremely low birthweight (ELBW) children are currently lacking. We assessed the effects of long-term supplementation of alpha-tocopherol on the neurological development of 259 school-aged ELBW children. Methods: Extremely low birthweight participants were divided into three groups: group A with no alpha-tocopherol supplementation (n = 121); group B with the supplementation for
