Accepted Manuscript Local Infiltration Analgesia for Postoperative Pain After Hip Arthroplasty: A Systematic Review and Meta-Analysis Jun-Bin Yin, M.D Guang-Bin Cui, M.D., Ph.D Ming-Shan Mi, M.D. Yu-Xia Du, M.D. Sheng-Xi Wu, M.D., Ph.D Yun-Qing Li, M.D., Ph.D Wen Wang, M.D., Ph.D PII:
S1526-5900(14)00651-8
DOI:
10.1016/j.jpain.2014.03.002
Reference:
YJPAI 2922
To appear in:
Journal of Pain
Received Date: 30 December 2013 Revised Date:
8 February 2014
Accepted Date: 6 March 2014
Please cite this article as: Yin J-B, Cui G-B, Mi M-S, Du Y-X, Wu S-X, Li Y-Q, Wang W, Local Infiltration Analgesia for Postoperative Pain After Hip Arthroplasty: A Systematic Review and Meta-Analysis, Journal of Pain (2014), doi: 10.1016/j.jpain.2014.03.002. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Local Infiltration Analgesia for Postoperative Pain After Hip Arthroplasty: A Systematic Review and Meta-Analysis Jun-Bin Yin, M.D.1,#, Guang-Bin Cui, M.D., Ph.D.1,2,#, Ming-Shan Mi, M.D.1,3,#,Yu-Xia Du, M.D.1,4, Sheng-Xi Wu, M.D., Ph.D.1,Yun-Qing Li, M.D., Ph.D.1, *, Wen Wang, M.D., Ph.D.1,*
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1 Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an 710032, PR China
2 Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710032, PR China
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3 Department of Orthopaedic, Affiliated Hospital of Qinghai University, 810001, Xining, PR China
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4 The Dental Department of Qinghai Provincial People's Hospital, 810001, Xining, PR China # These authors contributed equally to this project. Corresponding Authors
Dr. Wen Wang, Unit for Evidence Based Medicine, Department of Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an PR
China.
E-mail:
[email protected];
Tel:
86-29-84773074;
Fax:
TE D
710032,
86-29-83283229.
Dr. Yun-Qing Li, Unit for Evidence Based Medicine, Department of Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an
EP
710032, PR China. E-mail: [email protected] Running Title: Local Infiltration Analgesia in Hip Arthroplasty
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Indexing: Local Infiltration Analgesia; Hip Arthroplasty; Postoperative Pain Disclosures:
Funding:This work was partly supported by Innovation International Science & Technology Cooperation Program of China (2011DFA32560, to SX Wu), Program for Shaanxi Province Key Research Team of Science and Technology Innovation (2012KCT-14, to SX Wu), the Natural Key Plan of Shaanxi province (2008K13-04, to GB Cui), intramural grant of the Fourth Military Medical University (to W Wang). All authors have viewed and agreed with this submission. There are no conflicts of interests including finance, honoraria, travel to conferences, consultancies, stock ownership and equity 1 / 24
ACCEPTED MANUSCRIPT
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interests.
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ACCEPTED MANUSCRIPT Abstract: Postoperative pain after hip arthroplasty (HA) is very common and unbearable. Currently, useful analgesic methods are often accompanied with obvious adverse events (AEs). Local infiltration analgesia (LIA) has been carried out for controlling pain as one potential therapeutic option in many surgical procedures. However, its analgesic efficacy in HA and safety
RI PT
remain unclear. Nine randomized controlled trials (RCTs) involving 760 participants were retrieved from an electronic database, comparing the effect of LIA with those of placebo infiltration or no infiltration on patients undergoing HA. Pain scores, analgesic consumption, and AEs were analyzed. Effects were summarized using weighed mean differences (WMD),
SC
standardized mean differences (SMD) or odds ratio (OR) with fixed or random effect models. There was strong evidence for an association between LIA and reduced pain scores at 4h at rest
M AN U
(P
S1526-5900(14)00651-8
DOI:
10.1016/j.jpain.2014.03.002
Reference:
YJPAI 2922
To appear in:
Journal of Pain
Received Date: 30 December 2013 Revised Date:
8 February 2014
Accepted Date: 6 March 2014
Please cite this article as: Yin J-B, Cui G-B, Mi M-S, Du Y-X, Wu S-X, Li Y-Q, Wang W, Local Infiltration Analgesia for Postoperative Pain After Hip Arthroplasty: A Systematic Review and Meta-Analysis, Journal of Pain (2014), doi: 10.1016/j.jpain.2014.03.002. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Local Infiltration Analgesia for Postoperative Pain After Hip Arthroplasty: A Systematic Review and Meta-Analysis Jun-Bin Yin, M.D.1,#, Guang-Bin Cui, M.D., Ph.D.1,2,#, Ming-Shan Mi, M.D.1,3,#,Yu-Xia Du, M.D.1,4, Sheng-Xi Wu, M.D., Ph.D.1,Yun-Qing Li, M.D., Ph.D.1, *, Wen Wang, M.D., Ph.D.1,*
RI PT
1 Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an 710032, PR China
2 Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710032, PR China
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3 Department of Orthopaedic, Affiliated Hospital of Qinghai University, 810001, Xining, PR China
M AN U
4 The Dental Department of Qinghai Provincial People's Hospital, 810001, Xining, PR China # These authors contributed equally to this project. Corresponding Authors
Dr. Wen Wang, Unit for Evidence Based Medicine, Department of Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an PR
China.
E-mail:
[email protected];
Tel:
86-29-84773074;
Fax:
TE D
710032,
86-29-83283229.
Dr. Yun-Qing Li, Unit for Evidence Based Medicine, Department of Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an
EP
710032, PR China. E-mail: [email protected] Running Title: Local Infiltration Analgesia in Hip Arthroplasty
AC C
Indexing: Local Infiltration Analgesia; Hip Arthroplasty; Postoperative Pain Disclosures:
Funding:This work was partly supported by Innovation International Science & Technology Cooperation Program of China (2011DFA32560, to SX Wu), Program for Shaanxi Province Key Research Team of Science and Technology Innovation (2012KCT-14, to SX Wu), the Natural Key Plan of Shaanxi province (2008K13-04, to GB Cui), intramural grant of the Fourth Military Medical University (to W Wang). All authors have viewed and agreed with this submission. There are no conflicts of interests including finance, honoraria, travel to conferences, consultancies, stock ownership and equity 1 / 24
ACCEPTED MANUSCRIPT
AC C
EP
TE D
M AN U
SC
RI PT
interests.
2 / 24
ACCEPTED MANUSCRIPT Abstract: Postoperative pain after hip arthroplasty (HA) is very common and unbearable. Currently, useful analgesic methods are often accompanied with obvious adverse events (AEs). Local infiltration analgesia (LIA) has been carried out for controlling pain as one potential therapeutic option in many surgical procedures. However, its analgesic efficacy in HA and safety
RI PT
remain unclear. Nine randomized controlled trials (RCTs) involving 760 participants were retrieved from an electronic database, comparing the effect of LIA with those of placebo infiltration or no infiltration on patients undergoing HA. Pain scores, analgesic consumption, and AEs were analyzed. Effects were summarized using weighed mean differences (WMD),
SC
standardized mean differences (SMD) or odds ratio (OR) with fixed or random effect models. There was strong evidence for an association between LIA and reduced pain scores at 4h at rest
M AN U
(P
