ABSTRACTS AND POSTERS List of Abstracts and Posters Presented at the 59th Thomas L. Petty Aspen Lung Conference ABSTRACTS

Assessment of Lungs for Transplant Recovered from Uncontrolled Donation after Circulatory Determination of Death Donors Thomas Egan1, J. Blackwell1, K. Birchard1, B. Haithcock1, J. Long1, S. Gazda1, N. Casey2, and C. Thys2 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and 2Carolina Donor Services, Durham, North Carolina

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Single Center Results with Normothermic Ex Vivo Lung Perfusion: A Propensity-matched Analysis Jonathan C. Yeung1, P. R. dos Santos, J. Reeb, K. Yasufuku, M. de Perrot, A. F. Pierre, T. K. Waddel1, S. Keshavjee1, and M. Cypel1 1

Toronto Lung Transplant Program, Division of Thoracic Surgery, University of Toronto, Toronto, Ontario, Canada

Formyl Peptide Receptor 1 Promotes Primary Graft Dysfunction in a Mouse Model of Orthotopic Lung Transplantation Davide Scozzi1, X. Lin1, X.-A. Wang1, M. Ibrahim1, H.-M. Hsiao1, A. S. Krupnick1,2, D. Kreisel1,2, and A. E. Gelman1,2 Department of Surgery and 2Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri

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Onset of Inflammation with Ischemia: Implications for Donor Lung Preservation and Transplant Survival J.-Q. Tao1, E. M. Sorokina1, J. Vasquez Medina1, M. K. Mishra2, Y. Yamada3, J. Satalin4, G. F. Nieman4, J.R. Nellen5, B. Beduhn5, E. Cantu5, N. M. Habashi6, W. Jungraithmayr3, J. D. Christie5,7, and Shampa Chatterjee1 Institute for Environmental Medicine and Department of Physiology, 2Department of Physiology, Pennsylvania Muscle Institute, Cardiovascular Surgery Division, and 7Pulmonary Allergy and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; 3Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland; 4Department of Surgery, SUNY Upstate Medical University, Syracuse, New York; and 6Surgical Critical Care, University of Maryland Medical Center, Baltimore, Maryland 1

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Lung Donors with Heavy Alcohol Use have Altered Systemic and Airway Inflammation Erin Lowery1, M. Young1, A. Cohen1, L. Ramirez1, E. Burnham2, and E. Kovacs1 1

Loyola University Chicago, Health Science Division, Maywood, Illinois; and 2University of Colorado, Denver, Aurora, Colorado

Cell-Free Hemoglobin-mediated Increases in Vascular Permeability: A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target Ciara M. Shaver, N. Wickersham, J. B. McNeil, H. Nagata, G. Sills, J. L. Kuck, D. R. Janz, J. A. Bastarache, and L. B. Ware Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

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ABSTRACTS AND POSTERS Ischemia Reperfusion-induced Genetic Expression Profiles in the Human Lung Bo Kim1, L. Johnston1, J. T. Magruder2, J. C. Grimm2, C. Talbot3, R. S. Stephens1, R. L. Damico1, P. M. Hassoun1, and A. S. Shah2 Division of Pulmonary and Critical Care Medicine, 2Division of Cardiac Surgery, 3Division of Basic Biomedical Sciences, and 4Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 1

Ex Vivo Repair of Ischemia-injured Donor Pig Lungs using Cell-based Therapy with Mesenchymal Stem Cells Daisuke Nakajima1, P. Mordant1, R. K. Iyer2, J. E. Davies2, M. Cypel1, M. Liu1, T. K. Waddell1, and S. Keshavjee1 1

Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; and 2Tissue Regeneration Therapeutics Inc., Toronto, Ontario, Canada

Inhibition of CCN2 Ameliorates Fibrosis in Orthotopic Trachea Transplantation Yu-Chun Lin1,2, X. Jiang1,2, and M. Nicolls1,2 Division of Pulmonary and Critical Care, Stanford University, Palo Alto, California; and 2VA Palo Alto Health Care System, Palo Alto, California 1

Endothelial HIF-2a Deficiency Disrupts Airway Microvascular Structure and Impairs the Repair of Vessels of Transplanted Airways Xinguo Jiang1,2, W. Tian1,2, A. B. Tu1,2, and M. R. Nicolls1,2 1

VA Palo Alto Health Care System, Palo Alto, California; and 2Stanford University School of Medicine, Stanford, California

Murine B1-B Cells Innately Recognize Collagen Type V as Danger Marker Lorenzo Zaffiri, K. Rothhaar, E. A. Mickler, A. J. Fisher, R. Stearman, M. Geraci, and D. S. Wilkes Indiana University, School of Medicine, Indianapolis, Indiana

IFN-g and Contact-Dependent Cytotoxicity are Rate-Limiting for NK Cells in a Model of Antibody-mediated Chronic Rejection Christine M. Lin1, R. J. Plenter2, and R. G. Gill3 1,2 University of Colorado, Denver, Anschutz Medical Campus, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Aurora, Colorado; and 3University of Colorado, Denver, Anschutz Medical Campus, Department of Surgery, Aurora, Colorado

Induction of the Pro-Inflammatory Ubiquitin E3 Ligase Subunit, Fbxo3, in Lung Allograft Rejection and Therapeutic Targeting using a Novel Small Molecule Inhibitor, BC-1261 T. A. Coon, E. A. Lendermon, R. K. Mallampalli, B. B. Chen, and John F. McDyer Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Cistrome-based Cooperation between Airway Epithelial Gluco-Corticoid Receptor and NF-kB Orchestrates Antiinflammatory Effects Vineela Kadiyala1, S. K. Sasse1, T. L. Phang2, and A. N. Gerber1,2 1

National Jewish Health, Denver, Colorado; and 2University of Colorado Anschutz Medical Campus, Aurora, Colorado

Abstracts and Posters

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ABSTRACTS AND POSTERS Central Role for Mucosal Epithelia IL-10 Signaling in Barrier Restitution Jordi M. Lanis1,2, E. E. Alexeev1,2, D. J. Kao1,2, L. Zheng1,2, V. F. Curtis1,2, D. A. Kitzenberg1,2, K. Schwisow1,2, D. J. Kominsky1,2, and S. P. Colgan1,2 1

Mucosal Inflammation Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and 2Department of Microbiology and Immunology, Montana State University, Bozeman, Montana

Regulation of Mucosal Barrier Function by Microbiota-derived Tryptophan Metabolites Erica E. Alexeev1, J. M. Lanis1, K. D. Schwisow1, D. J. Kominsky2, and S. P. Colgan1 Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado; and 2Department of Microbiology and Immunology, Montana State University, Bozeman, Montana 1

Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction S. Samuel Weigt1, X. Wang1, V. Palchevskiy1, N. Patel1, A. Derhovanessian1, M. Y. Shino1, D. M. Sayah1, A. L. Gregson1, J. P. Lynch III1, R. Saggar1, D. J. Ross1, A. Ardehali2, D. Elashoff1, and J.A. Belperio1 1

Department of Medicine and 2Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, California

Stratification of Chronic Lung Allograft Dysfunction Phenotypes using Proteomic Profiling of BAL-Fluid Natalia Smirnova1, H. B. Schiller1,2, N. Kneidinger3, J. Behr3, M. Mann2, and O. Eickelberg1 1

Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum M¨unchen, Member of the German Center for Lung Research (DZL), Munich, Germany; 2Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany; and 3Department of Internal Medicine V, Comprehensive Pneumology Center, Comprehensive Pneumology Center Munich (CPC-M), University of Munich, Munich, Germany, Member of the German Center for Lung Research (DZL)

Bioactive Lipid Mediators Regulate Lung Epithelial and Mesenchymal Cell Reparative Processes In Vitro Tara M. Nordgren1, A. J. Heires1, K. L. Bailey1,2, and D. J. Romberger1,2 Pulmonary, Critical Care, Sleep and Allergy Division, University of Nebraska Medical Center, Omaha, Nebraska; and 2VA Nebraska Western Iowa Healthcare System, Omaha, Nebraska 1

Recombinant Human CC10 Protein for Chronic Lung Transplant Rejection A. Pilon1, Thomas Miller1, and A. H. Cohen1,2 1

Therabron Therapeutics, Inc., Rockville, Maryland; and 2Stanford University School of Medicine, Stanford, California

Microhemorrhage-associated Tissue Iron Enhances the Risk for Aspergillus Fumigatus Invasion in Transplantation Joe L. Hsu1,2, M. Inayathulla2, A. B. Tu1, K. V. Clemons2,3, X. Jiang1, J. Rajadas2; D. A. Stevens2,3, and M. R. Nicolls1,2 VA Palo Alto Health Care System/Stanford University School of Medicine, and 2Stanford University School of Medicine, Stanford, California; 3California Institute for Medical Research, San Jose, California 1

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ABSTRACTS AND POSTERS Lentivirus IL-10 Gene Therapy Attenuates Acute Rejection and Features of Chronic Lung Allograft Dysfunction after Murine Orthotopic Lung Transplantation Hisashi Oishi1, S. C. Juvet1, T. Martinu1, M. Sato1,2, Z. Guan1, S. Hirayama3, M. Cypel1, D. M. Hwang1, J. A. Medin4, M. Liu1, and S. Keshavjee1 Latner Thoracic Surgery Research Laboratories, University of Toronto, Toronto, Ontario, Canada; 2Department of Thoracic Surgery, University of Tokyo, Tokyo, Japan; 3Department of Thoracic Surgery, Kobe City Medical Center West Hospital, Kobe, Japan; and 4 Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 1

Regenerative Potential of Human Airway Stem Cells in Lung Epithelial Engineering for Transplantation Sarah E. Gilpin, J. M. Charest, L. F. Tapias, X. Ren, T. Wu, D. E. L. Da Silva, D. J. Mathisen, and H. C. Ott Massachusetts General Hospital, Center for Regenerative Medicine, Boston, Massachussetts

Circulating Elastase Confers a High Risk for the Development of Bronchiolitis Obliterans Syndrome C. E. Milla, J. M. Zirbes, A. Yacob, L. Tian, R. T. Zamanian, M. Bental-Roof, R. Bland, M. Rabinovitch, G. Dhillon, and Mark R. Nicolls Stanford University School of Medicine, Stanford, California

POSTERS Clinical

Effect of Lung Allocation by Prioritizing on Abo Compatibility J. J. Mooney, L. Chhatwani, and Gundeep S. Dhillon Department of Medicine, Stanford University, Stanford, California

Ethnicity and Waitlist Outcomes in Lung Transplant Candidates J. J Mooney, H. Hedlin, P. Mohabir, and Gundeep S. Dhillon Department of Medicine, Stanford University, Stanford, California

Circulating NITRIC Oxide Bioactivity and Lung Injury after Brain Death Maroun Matta1,2,3, A. Aldamouk1,2,3, L. Zhu1,2,3, R. Schilz1,2,3, R. J. Folz1,2,3, J. S. Stamler1,2,3, and J. D. Reynolds1,2,3 1 Institute for Transformative Molecular Medicine, 2Department of Medicine, and 3Department of Anesthesiology, University Hospital Case Medical Center, Case Western Reserve University Hospital, Cleveland, Ohio

Uncontrolled DCD with Prolonged Ex Vivo Lung Perfusion (EVLP): A Feasible Model for Donor Lung Recovery and Allocation John R. Spratt1,2, L. M. Mattison1,2, P. Iaizzo1,2, T. Iles1,2, M. I. Hertz1,2, and G. Loor1,2 Department of Surgery and 2Department of Medicine (Pulmonology), University of Minnesota, Minneapolis, Minnesota

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Abstracts and Posters

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ABSTRACTS AND POSTERS A Comparison of Prolonged Swing Lung Preservation using Packed Red Blood Cells, Donor Whole Blood, and Acellular Solution using the Organ Care System (OCS™) Lars M. Mattison1,2, G. Loor1,2, J. R. Spratt1,2, B. T. Howard1,2, T. L. Iles1,2, P. Meyer1,2, T. Day1,2, A. Panoskaltsis-Mortari1,2, M. Hertz1,2, and P. A. Iaizzo1,2 1

Department of Surgery and 2Department of Medicine (Pulmonology), University of Minnesota, Minneapolis, Minnesota

Medical Comorbidities of Uncontrolled Donation after Circulatory Determination of Death Donors (UDCDDS): Impact on the Size of the Pulmonary Donor Pool Thomas Egan1, N. Casey2, and C. Thys2 1

University of Carolina at Chapel Hill, Chapel Hill, North Carolina; and 2Carolina Donor Services, Durham, North Carolina

Stakeholders in the Process of Lung Recovery from Uncontrolled Donation after Circulatory Determination of Death Donors (UDCDDS) Thomas Egan1 and J. Requard III2 1

University of Carolina at Chapel Hill, Chapel Hill, North Carolina; and 2Lung Banks of America, Chapel Hill, North Carolina

Imatinib Protects Against Ischemia-Reperfusion Injury in an Ex Vivo Rabbit Model of Primary Graft Dysfunction J. T. Magruder1, J. C. Grimm1, L. Santhanam3, R. S. Stephens2, D. E. Berkowitz3, L. Johnston2, R. L. Damico2, P. M. Hassoun2, A. S. Shah1, and Bo Kim2 Division of Cardiac Surgery, 2Division of Pulmonary and Critical Care Medicine, and 3Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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Intravenous Immune Globulin (IVIg) Monotherapy for Preexisting and De Novo Donor-Specific Antibody (DSA) after Lung Transplantation (LTX) Reda E. Girgis1,2, J. A. Gerlach2, S. Jansma1, E. Beuker1, and M. Strueber1,2 Richard DeVos Heart and Lung Transplant Program, Spectrum Health, Grand Rapids, Michigan; and 2Michigan State University College of Human Medicine, East Lansing and Grand Rapids, Michigan 1

Clinical/Basic Science

Cardiovascular Risk Factors, Comorbidities, and Concomitant Medications from Three Phase 3 Trials of Pirfenidone in Idiopathic Pulmonary Fibrosis Marilyn K. Glassberg1, S. D. Nathan2, C. Lew3, K. Raimundo3, B.-M. Day3, J. Stauffer3, W. Chou3, and P. W. Noble4 1 University of Miami Health System, Miami, Florida; 2Inova Fairfax Hospital, Falls Church, Virginia; 3Genentech, Inc., South San Francisco, California; and 4Cedars Sinai Medical Center, Los Angeles, California

Cardiovascular Events in Phase 3 Trials of Pirfenidone in Idiopathic Pulmonary Fibrosis (IPF) Marilyn K. Glassberg1, S. D. Nathan2, C.-Y. Lin3, C. Lew3, K. Raimundo3, J. Stauffer3, W. Chou3, and P. W. Noble4 University of Miami Health System, Miami, Florida; 2Inova Fairfax Hospital, Falls Church, Virginia; 3Genentech, Inc., South San Francisco, California; and 4Cedars Sinai Medical Center, Los Angeles, California 1

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ABSTRACTS AND POSTERS Effect of Continued Treatment with Pirfenidone Following a >10% Relative Decline in Percent Predicted FVC in Patients with Idiopathic Pulmonary Fibrosis (IPF) S. D. Nathan1, C. Albera2, U. Costabel3, I. Glaspole4, Marilyn K. Glassberg5, L. Lancaster6, D. J. Lederer7, C. A. Pereira8, J. J. Swigris9, B.-M. Day10, W. Chou10, and A. U. Wells11 Inova Fairfax Hospital, Falls Church, Virginia; 2University of Turin, Turin, Italy; 3Ruhrlandkinik, Essen, Germany; 4Alfred Hospital, Melbourne, Australia; 5University of Miami Miller School of Medicine, Miami, Florida; 6Vanderbilt University Medical Center, Nashville, Tennessee; 7Columbia University Medical Center, New York, New York; 8Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil; 9National Jewish Health, Denver, Colorado; 10Genentech, Inc., South San Francisco, California; and 11Royal Brompton Hospital, London, United Kingdom 1

Spastic Esophageal Motility Disorders in Post–Lung Transplant Patients K. Regalia1, A. Sweatt2, Laveena Chhatwani2, J. Mooney2, G. Dhillon2, and L. Nguyen1 Division of Gastroenterology and 2Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California

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Combined Lung-Liver Transplantation: An Updated SRTR Analysis Shravani Pasupneti, J. J. Mooney, and G. Dhillon Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, California

Pulmonary Complications of Stevens Johnson Syndrome: A Single Center Experience Deborah R. Liptzin, J. G. Morelli, J. P. Weinman, M. E. Kroehl, and R. R. Deterding University of Colorado School of Medicine, Children’s Hospital Colorado, Aurora, Colorado

Using Clinical Quantitative CT Tools to Improve Diagnosis of Bronchiolitis Obliterans Syndrome Deborah R. Liptzin, E. M. DeBoer, M. E. Kroehl, R. H. Giller, and J. P. Weinman University of Colorado School of Medicine, Children’s Hospital Colorado, Aurora, Colorado

IL-10: In Need for Innovative Technologies to Harness this Most Powerful Endogenous Immune-Suppressor for Repair and Regeneration in the Lungs N. Durmus, B. Bleck, J. Reibman, and Gabriele Grunig New York University Langone Medical Center, New York, New York

FGF2 Overexpression Decreases Bleomycin-induced Pulmonary Fibrosis Robert D. Guzy1,2, L. Li2, S. Cilvik2, S. House3, and D. M. Ornitz2 Department of Internal Medicine, Section of Pulmonary and Critical Care, The University of Chicago, Chicago, Illinois; 2Department of Developmental Biology and 3Division of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri 1

The Influence of ENPP1 Expression in Mucosal Tissues Valerie F. Curtis, K. Schwisow, J. S. Lee, and S. P. Colgan Mucosal Inflammation Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

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ABSTRACTS AND POSTERS High-Energy Phosphates and Mucosal Inflammation J. Scott Lee, B. C. Tooker, L. E. Glover, and S. P. Colgan Mucosal Inflammation Program and Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

Orthotopic Lung Transplantation in a Single-Mismatch-based Mouse Model Shows Signs of Chronic Lung Allograft Dysfunction (CLAD) ¨ Yildirim, and O. Eickelberg Natalie Smirnova, T. Conlon, A. O. Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum M¨unchen, Member of the German Center for Lung Research (DZL), Munich, Germany

Gene Expression Profiles, MUC5B Genotype, and Asymptomatic Fibrotic Interstitial Lung Disease in an At-Risk Cohort Susan K. Mathai1, A. D. Walts1, J. Powers1, D. A. Lynch2, J. H. Chung2, K. S. Smith1, J. Woodward1, J. E. Loyd3, K. K. Brown2, M. P. Steele3, M. I. Schwarz1, T. E. Fingerlin2, I. V. Yang1, and D. A. Schwartz1 1

Division of Pulmonary Sciences and Critical Care Medicine and the Department of Medicine University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado; 2National Jewish Health, Denver, Colorado; 3Vanderbilt University School of Medicine, Division of Pulmonary and Critical Care Medicine, Nashville, Tennessee

The Involvement of MUC5B in Honeycomb Cyst Formation Provoked by Influenza Jonathan S. Kurche, J. P. Huber, L. A. Warg, C. M. Evans, and D. A. Schwartz Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado

Coordinated Immune Activation by Distinct Mononuclear Phagocytes Subtypes against the Mismatch of Minor Antigens S. M. Atif1, S. L. Gibbings1, R. G. Gill2, K. M. Murphy3,4, T. J. Grazia2, R. Torres2, P. M. Henson1,2, G. J. Randolph3, and Claudia Jakubzick1,2 Department of Pediatrics, National Jewish Health, Denver, Colorado; 2Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; 3Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri; 4Howard Hughes Medical Institute, Chevy Chase, Maryland; and 5Department of Biomedical Research, National Jewish Health, Denver, Colorado 1

Early Graft Injury Measured by Donor-derived Cell-Free DNA Predicts Early Mortality in Lung Transplant Recipients Sean Agbor-Enoh1,2,3, I. De Vlaminck4, J. Orens2,3, P. Shah2,3, A. Jackson2,3, I. Timofte3,5, A. Iacono3,5, S. Nathan6, GRAfT Investigators3, K. Patel7, K. Khush7, and H. Valantine1,3 National Heart, Lung, and Blood Institute, Bethesda, Maryland; 2The Johns Hopkins School of Medicine, Baltimore, Maryland; 3Genomic Research Alliance for Transplantation; 4Cornell University, Ithaca, New York; 5University of Maryland Medical Center, Baltimore, Maryland; 6INOVA Fairfax Hospital, Falls Church, Virginia; and 7Stanford University, Stanford, California 1

Validation (Reproducibility) of Genomic Data using Standards–Cell-Free DNA to Monitor Graft Injury Sean Agbor-Enoh1,2,3, I. Tunc1, J. Zhu1, X. Wang1, U. Fideli1,5, K. Cuttin1,5, K. Bhatti1,3, A. Jackson2,3, G. Graninger4, B. Harper4, M. A. Solomon1,4, H. Luikart4, 3GRAfT Investigators, I. De Vlaminck5,, K. Khush5, H.A. Valantine1,3 National Heart, Lung and Blood Institute, Bethesda, Maryland; 2The Johns Hopkins University, Baltimore, Maryland; 3Genomic Research Alliance for Transplantation; 4Clinical Center, National Institutes of Health, Bethesda, Maryland; and 5Stanford University, Stanford, California 1

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List of Abstracts and Posters Presented at the 59th Thomas L. Petty Aspen Lung Conference.

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