Licensing Adaptive Immunity by NOD-Like Receptors.

The innate immune system is composed of a diverse set of host defense molecules, physical barriers, and specialized leukocytes and is the primary form...
869KB Sizes 9 Downloads 0 Views

Recommend Documents


Adaptive immunity to fungi.
Life-threatening fungal infections have risen sharply in recent years, owing to the advances and intensity of medical care that may blunt immunity in patients. This emerging crisis has created the growing need to clarify immune defense mechanisms aga

Evolving adaptive immunity.
Generation of a diverse repertoire of antigen receptor specificities via DNA recombination underpins adaptive immunity. In this issue ofGenes&Development, Carmona and colleagues (pp. 909-917) provide novel insights into the origin and function of rec

CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity.
The constant region of IgG antibodies mediates antiviral activities upon engaging host Fcγ receptors (FcγRs) expressed by a variety of immune cells, such as antibody-dependent cellullar cytotoxcity (ADCC) executed by natural killer (NK)cells. Human c

Type I and type II Fc receptors regulate innate and adaptive immunity.
Antibodies produced in response to a foreign antigen are characterized by polyclonality, not only in the diverse epitopes to which their variable domains bind but also in the various effector molecules to which their constant regions (Fc domains) eng

Control of adaptive immunity by the innate immune system.
Microbial infections are recognized by the innate immune system both to elicit immediate defense and to generate long-lasting adaptive immunity. To detect and respond to vastly different groups of pathogens, the innate immune system uses several reco

Engaging adaptive immunity with biomaterials.
Adaptive immune responses, characterized by T cells and B cells engaging and responding to specific antigens, can be raised by biomaterials containing proteins, peptides, and other biomolecules. How does one avoid, control, or exploit such responses?

Tumors STING adaptive antitumor immunity.
Immunotherapy is revolutionizing the treatment of cancer patients, but the molecular basis for tumor immunogenicity is unclear. In this issue of Immunity, Deng et al. (2014) and Woo et al. (2014) provide evidence suggesting that dendritic cells detec