Original Article http://dx.doi.org/10.4070/kcj.2016.46.3.402 Print ISSN 1738-5520 • On-line ISSN 1738-5555
Korean Circulation Journal
Levosimendan Reduces Lung Injury in a Canine Model of Cardiopulmonary Bypass Junbo Feng, MD1, Haiyuan Liu, MD2, Jiayi Chen, MD1, Jiyuan Wang, MD1, Zhuang Liu, MD1, and Shenglin Ge, MD1 1
The First Ward of Cardiovascular Surgery Department of the First Affiliated Hospital of Anhui Medical University, 2The Oncology Department of the Hefei Second People’s Hospital, Hefei, China
Background and Objectives: To explore the lung-protective effect of levosimendan (LS) during cardiopulmonary bypass in a canine model by determining the wet/dry weight (W/D) ratio of lung tissue, malonaldehyde (MDA) and superoxide dismutase (SOD) concentrations, and performing a histological evaluation. Materials and Methods: Thirty-two canines were divided randomly into four groups and underwent a routine aortic cross-clamping cardiopulmonary bypass procedure for 1 h, followed by recovery for 2 h. Animals were handled as follows: group C (means control group), no special treatment after aortic cross clamping; group P (means pulmonary artery perfusion group), pulmonary artery perfusion with cold oxygenated blood after aortic cross clamping; group LSIV (means intravenous injection of LS group), intravenous injection of LS (65 µg/kg) before thoracotomy, and the rest of the procedure was identical to the control group; group LPS (means pulmonary perfusion with LS group), pulmonary perfusion with cold oxygenated blood combined with LS (65 µg/kg) after aortic cross clamping. Lung tissues were removed and subjected to evaluation of pathological alterations, W/D ratio and MDA and SOD concentrations. Results: In group C, the W/D ratio and MDA concentration were higher, while the SOD concentrations were lower (p
Korean Circulation Journal
Levosimendan Reduces Lung Injury in a Canine Model of Cardiopulmonary Bypass Junbo Feng, MD1, Haiyuan Liu, MD2, Jiayi Chen, MD1, Jiyuan Wang, MD1, Zhuang Liu, MD1, and Shenglin Ge, MD1 1
The First Ward of Cardiovascular Surgery Department of the First Affiliated Hospital of Anhui Medical University, 2The Oncology Department of the Hefei Second People’s Hospital, Hefei, China
Background and Objectives: To explore the lung-protective effect of levosimendan (LS) during cardiopulmonary bypass in a canine model by determining the wet/dry weight (W/D) ratio of lung tissue, malonaldehyde (MDA) and superoxide dismutase (SOD) concentrations, and performing a histological evaluation. Materials and Methods: Thirty-two canines were divided randomly into four groups and underwent a routine aortic cross-clamping cardiopulmonary bypass procedure for 1 h, followed by recovery for 2 h. Animals were handled as follows: group C (means control group), no special treatment after aortic cross clamping; group P (means pulmonary artery perfusion group), pulmonary artery perfusion with cold oxygenated blood after aortic cross clamping; group LSIV (means intravenous injection of LS group), intravenous injection of LS (65 µg/kg) before thoracotomy, and the rest of the procedure was identical to the control group; group LPS (means pulmonary perfusion with LS group), pulmonary perfusion with cold oxygenated blood combined with LS (65 µg/kg) after aortic cross clamping. Lung tissues were removed and subjected to evaluation of pathological alterations, W/D ratio and MDA and SOD concentrations. Results: In group C, the W/D ratio and MDA concentration were higher, while the SOD concentrations were lower (p
