The Hospital for Sick Children centennial To the editor: The Journal issue commemorating the centennial of The Hospital for Sick Children in Toronto (Can Med Assoc J 113: 485, 1975) brought back many memories of that hospital, where I served on the pediatric house staff during 1926-28. I'll admit that the original articles of the cLirrent contributors were almost incomprehensible to a scientific illiterate, and Saul Levine's viewpoint on "The mythology of contemporary youth" leaves me confused. If "Musings" means meditation and pondering in Silence, Helen Reid's explosive piece scarcely qualifies, and what about that retrospective contribution to science fiction "Age, sex and seasonal incidence of diseases in childhood",1 in which I narrowly escaped et al status after Brown and Tisdall? However, when I came to the editorials, to Harry Ebb's appreciation of Alan Brown and Doug Wallace's view of "Sick Kids", I was on more familiar ground. Several of the great men and women who were my teachers and supervisors are mentioned, but I'd like to add to the roster. Six months in pathology with Ike Erb made me expert in the blood grouping techniques of the day, a fair amateur bacteriologist and an admirer of the skilled tissue pathologist. A similar period on the infectious ward under the austere domination of Beverley Hannah exposed me to all the exanthemas, to diphtheria, cerebrospinal meningitis and even typhoid. The infant ward, boys' medical, girls' medical and the outpatients' department were territories of Brownsville and they operated with painstaking efficiency under his lieutenants AIf Hart, Theo Drake, Ted Morgan, Gladys Boyd, Red Murray and others I can't recall. Summer diarrhea, otitis media, mastoiditis, pneumonia, erysipelas and tuberculous infections of all body tissues were our daily fare. What's more, you had to get the history and lab work done on the child admitted at 2 am or else you'd catch it at morning rounds. The institution at 67 College St. had a small, closely knit staff and one was apt to find the surgeons D.E. Robertson and R.I. Harris lunching in the interns' dining room and discussing for our benefit the details of the day's interesting cases. Fellow residents and interns included Harold Price, Cecil Shaver, Stuart Murray, Nelles Silverthorne, Doris Monypenny, Ernie Janes, Murray Meekison, Tim Wansbrough, Lou Hudson, Joe Sullivan and Roy Huggard - a band so dedicated to the
"Kids" that a fianc.(e) could scarcely entice them out on a Sunday afternoon. Yes, I participated in the 50th anniversary of The Hospital for Sick Children on College Street and I predict that the hospital on University Avenue will go from strength to strength through its 2nd century. A.D. KELLY, MB
5 Edmund Gate Toronto, ON
Reference 1. BROWN A, TISOALL FE, KELLY AD: Age, sex and seasonal incidence of diseases in childhood. Am I Dis Child 39: 163, 1930
International fellowship for advanced biomedical studies To the editor: The Mario Negri Institute for Pharmacological Research of Milan, Italy, and the Mario Negri Institute Foundation, Inc. of New York invite applications for the 1976-77 Johananoff International Fellowship for Advanced Biomedical Studies. The purpose of the Johananoff Fellowship is to offer a distinguished scientist, internationally renowned for outstanding contributions in cancer chemotherapy and/or immunology, cardiovascular pharmacology, neuropsychopharmacology or drug metabolism the opportunity to spend his or her sabbatical year at the Mario Negri Institute for Pharmacological Research in Milan. Eligible candidates should be other than Italian citizens, who are actively engaged in advanced research in one of the specialized fields mentioned. Only scientists from academic or nonprofit institutions and government agencies will be considered. Applications for 1976-77 should be airmailed no later than Jan. 28, 1976 and must include the following: curriculum vitae, list of publications, reprints of pertinent papers and an outline of the proposed study (about 250 words). The award will be announced by Mar. 30, 1976 and its recipient may come to Milan any time thereafter, provided it is within 1976. Applications and requests for further information should be airmailed to the address given below. The amount of the award is $15000 for 1 year, including stipend and travel. There are no objections to the Johananoff Fellow retaining his or her regular stipend and other support. The Johananoff Fellowship Committee Instituto di Ricerche Farmacologiche "Mario Negri" Via Eritrea, 62 20157 Milan Italy
1026 CMA JOURNAL/DECEMBER 13, 1975/VOL. 113
Apresoline
the unique "ADD ON" antihypertensive INDICATIONS: Various forms of hypertension: fixed essential hypertension, whether of benign or malignant character; hypertension associated with acute and chronic glomerulonephritis; nephrosclerosis; hypertensive toxemias of pregnancy, pre-eclampsia, and eclampsia. DOSAGE: Hypertension: Orally: In general after initiating therapy gradually increase dosage, adjusting according to individual response. As a single agent, initially 10 mg, four times daily increasing slowly to a maximum practical dosage of 200mg daily. In combination with other hypotensive agents, lower dosages of APRESOLINE will be appropriate. Parenterally: When there is urgent need, therapy in the hospitalized patient may be initiated intravenously or intramuscularly. Usual dose is 20 to 40 mg, repeated as necessary. Certain patients, especially those with marked renal damage, may require a lower dose. Pressure may begin to fall within a few minutes after injection, with an average maximal decrease occurring in 10 to 80 minutes. Most patients can be transferred to oral APRESOLINE within 24 to 48 hours. Toxemia of Pregnancy: a) Early toxemia and hypertension of pregnancy: One 10-mg tablet orally 4 times daily, slowly increasing the dosage up to 400 mg per day, or until a therapeutic result is obtained. b) Late toxemia and pre-eclampsia: Give 20 to 40 mg intramuscularly, or slowly by direct intravenous injection or infusion. Repeat as necessary. SIDE EFFECTS: Tachycardia, headache, palpitation, dizziness, weakness, nausea, vomiting, postural hypotension, numbness and tingling of the extremities, flushing, nasal congestion, lachrymation, conjunctival injection, dyspnea, anginal symptoms, rash, drug fever, reduction in hemoglobin and red cell count, giant urticaria, and a lupus-like syndrome (arthralgia) in some cases following administration for long periods. CAUTIONS: Use cautiously in the presence of advanced renal damage and recent coronary or cerebral ischemia. APRESOLINE may potentiate the narcotic effects of barbiturates and alcohol. Peripheral neuritis evidenced by paresthesias, numbness and tingling has been observed. Published evidence suggests an anti-pyridoxine effect and addition of pyridoxine to the regimen if symptoms develop. OVERDOSAGE: Symptoms: Hypotension and tachycardia. Treatment: Gastric lavage or, in the absence of coma, emetics. In the presence of hypotension, cautiously give norepinephrine (intravenously) or ephedrine to raise the blood pressure without increasing tachycardia. Avoid epinephrine. General supportive measures include intravenous fluids, external heat, and elevation of foot of bed. SUPPLIED: All forms contain hydralazine hydrochloride Tablets of 10mg (yellow, scored); bottles of 100. Tablets of 25mg (blue, coated); bottles of 100 and 500. Tablets of 50mg (pink, coated); bottles of 100 and 500. Ampoules of 1 ml aqueous solution containing 20 mg; boxes of 10.
CIBA DORVAL, QUEBEC
0-5003
"Kids" that a fianc.(e) could scarcely entice them out on a Sunday afternoon. Yes, I participated in the 50th anniversary of The Hospital for Sick Children on College Street and I predict that the hospital on University Avenue will go from strength to strength through its 2nd century. A.D. KELLY, MB
5 Edmund Gate Toronto, ON
Reference 1. BROWN A, TISOALL FE, KELLY AD: Age, sex and seasonal incidence of diseases in childhood. Am I Dis Child 39: 163, 1930
International fellowship for advanced biomedical studies To the editor: The Mario Negri Institute for Pharmacological Research of Milan, Italy, and the Mario Negri Institute Foundation, Inc. of New York invite applications for the 1976-77 Johananoff International Fellowship for Advanced Biomedical Studies. The purpose of the Johananoff Fellowship is to offer a distinguished scientist, internationally renowned for outstanding contributions in cancer chemotherapy and/or immunology, cardiovascular pharmacology, neuropsychopharmacology or drug metabolism the opportunity to spend his or her sabbatical year at the Mario Negri Institute for Pharmacological Research in Milan. Eligible candidates should be other than Italian citizens, who are actively engaged in advanced research in one of the specialized fields mentioned. Only scientists from academic or nonprofit institutions and government agencies will be considered. Applications for 1976-77 should be airmailed no later than Jan. 28, 1976 and must include the following: curriculum vitae, list of publications, reprints of pertinent papers and an outline of the proposed study (about 250 words). The award will be announced by Mar. 30, 1976 and its recipient may come to Milan any time thereafter, provided it is within 1976. Applications and requests for further information should be airmailed to the address given below. The amount of the award is $15000 for 1 year, including stipend and travel. There are no objections to the Johananoff Fellow retaining his or her regular stipend and other support. The Johananoff Fellowship Committee Instituto di Ricerche Farmacologiche "Mario Negri" Via Eritrea, 62 20157 Milan Italy
1026 CMA JOURNAL/DECEMBER 13, 1975/VOL. 113
Apresoline
the unique "ADD ON" antihypertensive INDICATIONS: Various forms of hypertension: fixed essential hypertension, whether of benign or malignant character; hypertension associated with acute and chronic glomerulonephritis; nephrosclerosis; hypertensive toxemias of pregnancy, pre-eclampsia, and eclampsia. DOSAGE: Hypertension: Orally: In general after initiating therapy gradually increase dosage, adjusting according to individual response. As a single agent, initially 10 mg, four times daily increasing slowly to a maximum practical dosage of 200mg daily. In combination with other hypotensive agents, lower dosages of APRESOLINE will be appropriate. Parenterally: When there is urgent need, therapy in the hospitalized patient may be initiated intravenously or intramuscularly. Usual dose is 20 to 40 mg, repeated as necessary. Certain patients, especially those with marked renal damage, may require a lower dose. Pressure may begin to fall within a few minutes after injection, with an average maximal decrease occurring in 10 to 80 minutes. Most patients can be transferred to oral APRESOLINE within 24 to 48 hours. Toxemia of Pregnancy: a) Early toxemia and hypertension of pregnancy: One 10-mg tablet orally 4 times daily, slowly increasing the dosage up to 400 mg per day, or until a therapeutic result is obtained. b) Late toxemia and pre-eclampsia: Give 20 to 40 mg intramuscularly, or slowly by direct intravenous injection or infusion. Repeat as necessary. SIDE EFFECTS: Tachycardia, headache, palpitation, dizziness, weakness, nausea, vomiting, postural hypotension, numbness and tingling of the extremities, flushing, nasal congestion, lachrymation, conjunctival injection, dyspnea, anginal symptoms, rash, drug fever, reduction in hemoglobin and red cell count, giant urticaria, and a lupus-like syndrome (arthralgia) in some cases following administration for long periods. CAUTIONS: Use cautiously in the presence of advanced renal damage and recent coronary or cerebral ischemia. APRESOLINE may potentiate the narcotic effects of barbiturates and alcohol. Peripheral neuritis evidenced by paresthesias, numbness and tingling has been observed. Published evidence suggests an anti-pyridoxine effect and addition of pyridoxine to the regimen if symptoms develop. OVERDOSAGE: Symptoms: Hypotension and tachycardia. Treatment: Gastric lavage or, in the absence of coma, emetics. In the presence of hypotension, cautiously give norepinephrine (intravenously) or ephedrine to raise the blood pressure without increasing tachycardia. Avoid epinephrine. General supportive measures include intravenous fluids, external heat, and elevation of foot of bed. SUPPLIED: All forms contain hydralazine hydrochloride Tablets of 10mg (yellow, scored); bottles of 100. Tablets of 25mg (blue, coated); bottles of 100 and 500. Tablets of 50mg (pink, coated); bottles of 100 and 500. Ampoules of 1 ml aqueous solution containing 20 mg; boxes of 10.
CIBA DORVAL, QUEBEC
0-5003
