93 mentions that 10% of patients are unable to tolerate long-term clonidine therapy, while withdrawal of the drug can lead to an extreme rise in blood-pressure. We feel, therefore, that other drugs are worth investigating. Labetalol seems promising, particularly in the acute hypertensive emergency, although full evaluation must await more extensive trial. E. AGABITI ROSEI J. J. BROWN P. M. TRUST M.R.C. Blood Pressure Unit, A. F. LEVER Western Infirmary, Glasgow G11 6NT. J. I. S. ROBERTSON

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Letter: Labetalol and clonidine in severe hypertension.

93 mentions that 10% of patients are unable to tolerate long-term clonidine therapy, while withdrawal of the drug can lead to an extreme rise in blood...
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