Accepted Article
Article Type: Regular Article
Less invasive surfactant administration is associated with improved pulmonary outcomes in spontaneously breathing preterm infants Wolfgang Göpel1 MD, Angela Kribs2 MD, Christoph Härtel1 MD, Stefan Avenarius3 MD, Norbert Teig4 MD, Peter Groneck5 MD, Dirk Olbertz6 MD, Claudia Roll7 MD, Matthias Vochem8 MD, Ursula Weller9 MD, Axel von der Wense10 MD, Christian Wieg11 MD, Jürgen Wintgens12 MD, Michael Preuss13, Andreas Ziegler13,14 Bernhard Roth2 MD, and Egbert Herting1 PhD, for the German Neonatal Network (GNN) Affiliations: From the Departments of Pediatrics at the Universities of 1Lübeck, , Magdeburg, 4Bochum, Departments of Neonatology at the Children’s Hospitals in 5Leverkusen, 6Rostock, 7Datteln, 8Olgahospital Stuttgart, 9Bielefeld, 10HamburgAltona, 11Aschaffenburg and 12Mönchengladbach and the 13Institute for Medical Biometry and Statistics, and the 14Center for Clinical Trials, University of Lübeck, Germany Cologne
2 3
Address correspondence to: Wolfgang Göpel, Department of Pediatrics, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Phone: + 49 451 500 2555, Fax: + 49 451 500 6986; E-mail: [email protected]
Short title: Less invasive surfactant administration and preterm infants
Financial Disclosure: The Authors have no financial relationships relevant to this article to disclose.
Conflict of interest: Dr. Herting and Dr. Groneck have worked on advisory boards for surfactant producing companies and companies working in the field of neonatal ventilation. The other authors have no conflicts of interest to disclose.
Abstract Aim. Providing less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported to reduce mechanical ventilation and bronchopulmonary dysplasia (BPD) in randomised controlled trials. This large cohort study compared these outcome measures between LISA treated infants and controls. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/apa.12883 This article is protected by copyright. All rights reserved.
Accepted Article
Methods. Infants receiving LISA, who were born before 32 gestational weeks and enrolled in the German Neonatal Network, were matched to control infants by gestational age, umbilical cord pH, Apgar-score at five minutes, small for gestational age status, antenatal treatment with steroids, gender and highest supplemental oxygen during the first 12 hours of life. Outcome data were compared with chi-square and Mann-Whitney U tests and adjusted for multiple comparisons.
Results. Between 2009 and 2012, 1,103 infants were treated with LISA at 37 centres. LISA infants had lower rates of mechanical ventilation (41% versus 62%, p
Article Type: Regular Article
Less invasive surfactant administration is associated with improved pulmonary outcomes in spontaneously breathing preterm infants Wolfgang Göpel1 MD, Angela Kribs2 MD, Christoph Härtel1 MD, Stefan Avenarius3 MD, Norbert Teig4 MD, Peter Groneck5 MD, Dirk Olbertz6 MD, Claudia Roll7 MD, Matthias Vochem8 MD, Ursula Weller9 MD, Axel von der Wense10 MD, Christian Wieg11 MD, Jürgen Wintgens12 MD, Michael Preuss13, Andreas Ziegler13,14 Bernhard Roth2 MD, and Egbert Herting1 PhD, for the German Neonatal Network (GNN) Affiliations: From the Departments of Pediatrics at the Universities of 1Lübeck, , Magdeburg, 4Bochum, Departments of Neonatology at the Children’s Hospitals in 5Leverkusen, 6Rostock, 7Datteln, 8Olgahospital Stuttgart, 9Bielefeld, 10HamburgAltona, 11Aschaffenburg and 12Mönchengladbach and the 13Institute for Medical Biometry and Statistics, and the 14Center for Clinical Trials, University of Lübeck, Germany Cologne
2 3
Address correspondence to: Wolfgang Göpel, Department of Pediatrics, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Phone: + 49 451 500 2555, Fax: + 49 451 500 6986; E-mail: [email protected]
Short title: Less invasive surfactant administration and preterm infants
Financial Disclosure: The Authors have no financial relationships relevant to this article to disclose.
Conflict of interest: Dr. Herting and Dr. Groneck have worked on advisory boards for surfactant producing companies and companies working in the field of neonatal ventilation. The other authors have no conflicts of interest to disclose.
Abstract Aim. Providing less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported to reduce mechanical ventilation and bronchopulmonary dysplasia (BPD) in randomised controlled trials. This large cohort study compared these outcome measures between LISA treated infants and controls. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/apa.12883 This article is protected by copyright. All rights reserved.
Accepted Article
Methods. Infants receiving LISA, who were born before 32 gestational weeks and enrolled in the German Neonatal Network, were matched to control infants by gestational age, umbilical cord pH, Apgar-score at five minutes, small for gestational age status, antenatal treatment with steroids, gender and highest supplemental oxygen during the first 12 hours of life. Outcome data were compared with chi-square and Mann-Whitney U tests and adjusted for multiple comparisons.
Results. Between 2009 and 2012, 1,103 infants were treated with LISA at 37 centres. LISA infants had lower rates of mechanical ventilation (41% versus 62%, p
