Int J Clin Exp Pathol 2014;7(3):1101-1107 www.ijcep.com /ISSN:1936-2625/IJCEP1401007
Original Article Lemur tyrosine kinase-3 is a significant prognostic marker for patients with colorectal cancer Hongbing Shi1*, Qing Li3*, Mei Ji1, Jun Wu1, Zhengguang Li1, Xiao Zheng2, Bin Xu2, Lujun Chen2, Xiaodong Li1, Changqing Lu3, Yan Tan3, Changping Wu1*, Jingting Jiang2* Departments of 1Oncology, 2Tumor Biological Treatment, 3Pathology, The Third Affiliated Hospital of Soochow University, Soochow, China. *Equal contributors. Received January 4, 2014; Accepted February 10, 2014; Epub February 15, 2014; Published March 1, 2014 Abstract: Lemur tyrosine kinase-3 (LMTK3) belongs to the family of serine-threonine-tyrosine kinases and the aberrant expression of LMTK3 was observed in several human malignancies. However, the association of LMTK3 with clinical outcomes in colorectal cancer patients is unclear. Thus, this present study was to evaluate the association of LMTK3 expression level with clinicopathologic factors and prognosis of patients with colorectal cancer (CRC). The expression level of LMTK3 in 69 archival paraffin-embedded colorectal tumor tissue specimens was examined by immunohistochemistry (IHC). As a result, we found that the LMTK3 expression level was significantly elevated in CRC tissues as compared with Crohn’s disease or colorectal polyp tissues (P
Original Article Lemur tyrosine kinase-3 is a significant prognostic marker for patients with colorectal cancer Hongbing Shi1*, Qing Li3*, Mei Ji1, Jun Wu1, Zhengguang Li1, Xiao Zheng2, Bin Xu2, Lujun Chen2, Xiaodong Li1, Changqing Lu3, Yan Tan3, Changping Wu1*, Jingting Jiang2* Departments of 1Oncology, 2Tumor Biological Treatment, 3Pathology, The Third Affiliated Hospital of Soochow University, Soochow, China. *Equal contributors. Received January 4, 2014; Accepted February 10, 2014; Epub February 15, 2014; Published March 1, 2014 Abstract: Lemur tyrosine kinase-3 (LMTK3) belongs to the family of serine-threonine-tyrosine kinases and the aberrant expression of LMTK3 was observed in several human malignancies. However, the association of LMTK3 with clinical outcomes in colorectal cancer patients is unclear. Thus, this present study was to evaluate the association of LMTK3 expression level with clinicopathologic factors and prognosis of patients with colorectal cancer (CRC). The expression level of LMTK3 in 69 archival paraffin-embedded colorectal tumor tissue specimens was examined by immunohistochemistry (IHC). As a result, we found that the LMTK3 expression level was significantly elevated in CRC tissues as compared with Crohn’s disease or colorectal polyp tissues (P
