714
answers to problems of hospital building may prove secondrate solutions. Yet we still have too little evidence on which to base decisions. The Oxford report drew its data from two tiny units. Surely the reasonable conclusion is that we do not yet know the best compromise between costs, medical efficiency, and what the patient wants. That being so, the planners might consider a more flexible approach. Why not offer a choice to one or two regions to act as pilot schemes based on one or other philosophy? Comparative trials have proved invaluable in clinical medicine; they may have a place in administration too. Rickards, J A, Cost-effectiveness Analysis of the Oxford Community Hospital. Oxford, Department of the Regius Professor of Medicine, 1976.
Left atrial myxoma Cardiac myxoma is one of those conditions whose rarity is matched only by the satisfaction of diagnosing and treating it. Occurring at any age but more often in women, such tumours, probably of mesenchymal origin, may be found in any chamber of the heart. Most commonly, however, they develop in the left atrium, where they usually arise from a pedicle on the atrial septum. Right atrial myxomas' are three to four times less common and ventricular ones even rarer. Necropsy evidence shows myxomas to constitute some half of all cardiac tumours.2-4 Macroscopically they may appear as either a firm globular or a soft polypoid mass, while microscopically there is endothelium covering an amorphous matrix containing malformed vessels, cords of vasoformative cells, and areas of necrosis and haemorrhage, together with a variable infiltrate of siderocytes, giant cells, lipophages, polymorphs, and lymphocytes.5 The clinical features of left atrial myxoma are protean and have been copiously described,6-'0 but new modes of presentation continue to occur, and isolated case histories are still being published. A left atrial myxoma becomes manifest by causing obstruction to the mitral valve or the pulmonary veins (often with secondary pulmonary hypertension), by systemic emboli, or more mysteriously by constitutional effects such as loss of weight, fever, anaemia, raised sedimentation rate, or an increase in gammaglobulin production. One of the most useful clinical reviews was that of Goodwin,8 who collected details of 45 patients from the Hammersmith Hospital and members of the British Cardiac Society. In this series the commonest constitutional features were raised sedimentation rate and fever, while dyspnoea, pulmonary hypertension, and mitral murmurs were the commonest obstructive features. When suspicion has been aroused the diagnosis must be confirmed by demonstrating a filling defect in the left atrium on angiography, first reported by Goldberg and colleagues in 1952.11 The left atrium should be outlined by injecting contrast into the pulmonary artery, for transseptal catheterisation carries the risk of dislodging fragments of tumour.1213 The advent of echocardiography, though not yet replacing angiography, has provided a safe, non-invasive method of investigation. Since the first report of its use in the diagnosis of an intra-atrial tumourl4 improved techniques have established its value. In using the conventional approach the ultrasonic beam is directed posteriorly from the fourth left intercostal space while the operator searches for echoes beneath the anterior
BRITISH MEDICAL JOURNAL
25 SEPTEMBER 1976
mitral valve cusp during diastole. These will be evident only if the tumour or part of its slips through the mitral valve during diastole. In a more recently described modification15 the beam is directed inferiorly from the suprasternal notch to traverse the aortic arch, right pulmonary artery, and left atrium. Petsas and colleagues16 have shown the usefulness of this method in a report of three cases of left atrial myxoma in which the tumour appeared as a cloud of echoes in the cavity of the left atrium. IMorrisey, J F, et al, American Heart Journal, 1963, 66, 4. 2
Yater, W M, Archives of Internal Medicine, 1931, 48, 627. Fawcett, R E M, and Ward, E M, British Heart Journal, 1939, 1, 249. Pritchard, R W, Archives of Pathology, 1951, 51, 98. Hudson, R E B, Cardiovascular Pathology, p 1565. London, Edward Arnold, 1965. 6 Campeau, L, and David, P, Canadian Medical Association Journal, 1960, 82, 586. 7 Aldridge, H E, and Greenwood, W F, British Heart3Journal, 1960, 22, 189. 8 Goodwin, J F, Lancet, 1963, 1, 464. 9 Greenwood, W F, American Journal of Cardiology, 1968, 21, 367. '0 Peters, M N, et al,J'ournal of the American Medical Association, 1974, 230, 695. 11 Goldberg, H P, et al, Circulation, 1952, 6, 762. 12 Marpole, D G F, et al, American 'ournal of Cardiology, 1969, 23, 597. 13 Pindyck, F, et al, American Journal of Cardiology, 1972, 30, 569. 14 Effert, S, and Domanig, E, German Medical Monthly, 1959, 4, 1. 15 Goldberg, B B,Journal of the American Medical Association, 1971,215, 245. 16 Petsas, A A, et al, British Heart Journal, 1976, 38, 627. 3 4 5
Audit again A new, and possibly useful, vocabulary is creeping into our jargon-ridden profession-peer review, utilisation review, activity analysis, medical audit. As Irving and Temple indicate on page 746, we are still largely at a loss to define these terms, either in a straightforward semantic way or in the effect they might have on human behaviour. Indeed, here lies the rub of the problem: if we are seized with the principle of selfexamination as a good thing, how do we translate the idea into reality and how do we find out if it works? Furthermore, Quis custodiet ipsos custodes ? How do we ensure that standards set and corrective action taken mirror the needs of the community and do not destroy personal endeavour ? Could we not rely on the innate sensitivity of the profession to the need to maintain standards, rather than constantly thrust the minutiae of performance under the noses of those who are at the sharp end of clinical practice ? These, and many other questions, are prompted by Irving and Temple's review of medical audit in a surgical setting. They describe all the care, which Dudley has also noted,' needed to nurture the delicate plant of open self-criticism. They take us clearly and instructively up the familiar climb of gradual acceptance of non-threatening debate. They have reached a plateau from which it might be possible to attack the real problem of altering human attitudes. It is here that they are on less secure ground. Such evidence as there is (and admittedly it is scanty) does not suggest that isolated debate-however amusing, cathartic, and apparently educational-has direct effects on how things are done. Indeed, medical audit often has many of the characteristics of a ritual rather than an instructive or constructive exercise and may be received by medical staff with indifference.2 To air problems is one thing; to change behaviour is another. These criticisms apart, it may be argued that information means control: to know about the incidence of complications, to have comparative statistics on length of stay, will auto-
answers to problems of hospital building may prove secondrate solutions. Yet we still have too little evidence on which to base decisions. The Oxford report drew its data from two tiny units. Surely the reasonable conclusion is that we do not yet know the best compromise between costs, medical efficiency, and what the patient wants. That being so, the planners might consider a more flexible approach. Why not offer a choice to one or two regions to act as pilot schemes based on one or other philosophy? Comparative trials have proved invaluable in clinical medicine; they may have a place in administration too. Rickards, J A, Cost-effectiveness Analysis of the Oxford Community Hospital. Oxford, Department of the Regius Professor of Medicine, 1976.
Left atrial myxoma Cardiac myxoma is one of those conditions whose rarity is matched only by the satisfaction of diagnosing and treating it. Occurring at any age but more often in women, such tumours, probably of mesenchymal origin, may be found in any chamber of the heart. Most commonly, however, they develop in the left atrium, where they usually arise from a pedicle on the atrial septum. Right atrial myxomas' are three to four times less common and ventricular ones even rarer. Necropsy evidence shows myxomas to constitute some half of all cardiac tumours.2-4 Macroscopically they may appear as either a firm globular or a soft polypoid mass, while microscopically there is endothelium covering an amorphous matrix containing malformed vessels, cords of vasoformative cells, and areas of necrosis and haemorrhage, together with a variable infiltrate of siderocytes, giant cells, lipophages, polymorphs, and lymphocytes.5 The clinical features of left atrial myxoma are protean and have been copiously described,6-'0 but new modes of presentation continue to occur, and isolated case histories are still being published. A left atrial myxoma becomes manifest by causing obstruction to the mitral valve or the pulmonary veins (often with secondary pulmonary hypertension), by systemic emboli, or more mysteriously by constitutional effects such as loss of weight, fever, anaemia, raised sedimentation rate, or an increase in gammaglobulin production. One of the most useful clinical reviews was that of Goodwin,8 who collected details of 45 patients from the Hammersmith Hospital and members of the British Cardiac Society. In this series the commonest constitutional features were raised sedimentation rate and fever, while dyspnoea, pulmonary hypertension, and mitral murmurs were the commonest obstructive features. When suspicion has been aroused the diagnosis must be confirmed by demonstrating a filling defect in the left atrium on angiography, first reported by Goldberg and colleagues in 1952.11 The left atrium should be outlined by injecting contrast into the pulmonary artery, for transseptal catheterisation carries the risk of dislodging fragments of tumour.1213 The advent of echocardiography, though not yet replacing angiography, has provided a safe, non-invasive method of investigation. Since the first report of its use in the diagnosis of an intra-atrial tumourl4 improved techniques have established its value. In using the conventional approach the ultrasonic beam is directed posteriorly from the fourth left intercostal space while the operator searches for echoes beneath the anterior
BRITISH MEDICAL JOURNAL
25 SEPTEMBER 1976
mitral valve cusp during diastole. These will be evident only if the tumour or part of its slips through the mitral valve during diastole. In a more recently described modification15 the beam is directed inferiorly from the suprasternal notch to traverse the aortic arch, right pulmonary artery, and left atrium. Petsas and colleagues16 have shown the usefulness of this method in a report of three cases of left atrial myxoma in which the tumour appeared as a cloud of echoes in the cavity of the left atrium. IMorrisey, J F, et al, American Heart Journal, 1963, 66, 4. 2
Yater, W M, Archives of Internal Medicine, 1931, 48, 627. Fawcett, R E M, and Ward, E M, British Heart Journal, 1939, 1, 249. Pritchard, R W, Archives of Pathology, 1951, 51, 98. Hudson, R E B, Cardiovascular Pathology, p 1565. London, Edward Arnold, 1965. 6 Campeau, L, and David, P, Canadian Medical Association Journal, 1960, 82, 586. 7 Aldridge, H E, and Greenwood, W F, British Heart3Journal, 1960, 22, 189. 8 Goodwin, J F, Lancet, 1963, 1, 464. 9 Greenwood, W F, American Journal of Cardiology, 1968, 21, 367. '0 Peters, M N, et al,J'ournal of the American Medical Association, 1974, 230, 695. 11 Goldberg, H P, et al, Circulation, 1952, 6, 762. 12 Marpole, D G F, et al, American 'ournal of Cardiology, 1969, 23, 597. 13 Pindyck, F, et al, American Journal of Cardiology, 1972, 30, 569. 14 Effert, S, and Domanig, E, German Medical Monthly, 1959, 4, 1. 15 Goldberg, B B,Journal of the American Medical Association, 1971,215, 245. 16 Petsas, A A, et al, British Heart Journal, 1976, 38, 627. 3 4 5
Audit again A new, and possibly useful, vocabulary is creeping into our jargon-ridden profession-peer review, utilisation review, activity analysis, medical audit. As Irving and Temple indicate on page 746, we are still largely at a loss to define these terms, either in a straightforward semantic way or in the effect they might have on human behaviour. Indeed, here lies the rub of the problem: if we are seized with the principle of selfexamination as a good thing, how do we translate the idea into reality and how do we find out if it works? Furthermore, Quis custodiet ipsos custodes ? How do we ensure that standards set and corrective action taken mirror the needs of the community and do not destroy personal endeavour ? Could we not rely on the innate sensitivity of the profession to the need to maintain standards, rather than constantly thrust the minutiae of performance under the noses of those who are at the sharp end of clinical practice ? These, and many other questions, are prompted by Irving and Temple's review of medical audit in a surgical setting. They describe all the care, which Dudley has also noted,' needed to nurture the delicate plant of open self-criticism. They take us clearly and instructively up the familiar climb of gradual acceptance of non-threatening debate. They have reached a plateau from which it might be possible to attack the real problem of altering human attitudes. It is here that they are on less secure ground. Such evidence as there is (and admittedly it is scanty) does not suggest that isolated debate-however amusing, cathartic, and apparently educational-has direct effects on how things are done. Indeed, medical audit often has many of the characteristics of a ritual rather than an instructive or constructive exercise and may be received by medical staff with indifference.2 To air problems is one thing; to change behaviour is another. These criticisms apart, it may be argued that information means control: to know about the incidence of complications, to have comparative statistics on length of stay, will auto-
