Vol. 31, No. 2

PEDIATRIC NEUROLOGY BRIEFS

February 2017

SEIZURE DISORDERS

Lacosamide in Pediatric Status Epilepticus Juan A. Piantino, MD1* 1

Department of Pediatrics, Section in Pediatric Neurology. Oregon Health and Science University, Portland, OR *Correspondence: Dr. Juan A. Piantino, E-mail: [email protected]

Related Article: Poddar K, Sharma R, Ng YT. Intravenous Lacosamide in Pediatric Status Epilepticus: An Open-Label Efficacy and Safety Study. Pediatr Neurol 2016 Aug;61:83–6. Keywords: Status Epilepticus; Lacosamide; Children; Seizures

Investigators from Baylor College of Medicine studied the efficacy of lacosamide in pediatric status epilepticus (SE). This is a single center, retrospective observational study of the use of IV lacosamide in children with SE. Nine children with a mean age of 5.7 years (2 months to 16 years) were enrolled in the study. SE was defined as continuous seizure activity longer than 20 minutes or two or more recurrent seizures without regaining baseline level of awareness. Efficacy was defined as seizure freedom or more than 50% reduction of seizures within 24 hours of administering lacosamide. The mean loading lacosamide dose was 8.7 mg/kg (7 received 10 mg/Kg). The total dose of lacosamide for the first 24 hours was 13.8 mg/Kg. Seven of nine patients (77.8%) experienced seizure improvement on lacosamide, and four patients (44.4%) became seizure free. Two patients continued to have SE within 24 hours of lacosamide administration. Bradycardia was observed in one patient. There were no other side effects documented in the study. [1] COMMENTARY. SE is a medical emergency consisting of persistent or recurring seizures. It is a heterogeneous condition which can be divided into subtypes with multiple underlying etiologies [2]. Care involves both termination of seizures and identification and management of any underlying conditions. Despite the dramatic increase in the number of anticonvulsants over the past decade, the treatment of SE still revolves around older mainstay IV anticonvulsants, fosphenytoin or phenobarbital. However, the evidence behind the use of these drugs remains sparse [3], and to date there are no randomized trials done exclusively in children comparing the efficacy of those drugs versus newer agents. In addition, the use of these drugs is often associated with adverse effects such as respiratory depression and hypotension. The use of lacosamide in SE has been documented in several observational studies in the adult population [4-6]. In those studies, the percentage of patients who experienced seizure cessation was 40-50%. A previous observational study in children reported resolution of SE in 45% of patients [7]. Podddar et al., report a 77.7% response rate, with 44.4% becoming seizure free. Interestingly, lacosamide seems to be well tolerated, with bradycardia in one of the 9 study subjects being the only reported adverse effect. There are, however, several limitations to this study,

which are recognized by the authors, the most significant one being sample size. In addition, several variables were not controlled for, including the dose of lacosamide, the administration of other anticonvulsants, and the timing of medication administration. Despite its limitations, this study adds to the accumulating body of literature suggesting that lacosamide is a promising and safe agent in the treatment of SE. Studies like this one are important as they highlight potential candidates for a very much needed randomized controlled trial of IV agents in pediatric SE. Disclosures

The author(s) have declared that no competing interests exist.

References

1. Poddar K, Sharma R, Ng YT. Intravenous Lacosamide in Pediatric Status Epilepticus: An Open-Label Efficacy and Safety Study. Pediatr Neurol 2016 Aug;61:83–6. https://doi.org/10.1016/j.pediatrneurol.2016 .03.021 PMID:27241232 2. Chin RF, Neville BG, Peckham C, Bedford H, Wade A, Scott RC; NLSTEPSS Collaborative Group. Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet 2006 Jul;368(9531):222–9. https://doi.org/10.1016/S0140-6736(06)69043-0 PMID: 16844492 3. Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ et al.; Veterans Affairs Status Epilepticus Cooperative Study Group. A comparison of four treatments for generalized convulsive status epilepticus. N Engl J Med 1998 Sep;339(12):792–8. https://doi.org/ 10.1056/NEJM199809173391202 PMID:9738086 4. Höfler J, Unterberger I, Dobesberger J, Kuchukhidze G, Walser G, Trinka E. Intravenous lacosamide in status epilepticus and seizure clusters. Epilepsia 2011 Oct;52(10):e148–52. https://doi.org/10.1111/ j.15281167.2011.03204.x PMID:21801171 5. Kellinghaus C, Berning S, Immisch I, Larch J, Rosenow F, Rossetti AO et al. Intravenous lacosamide for treatment of status epilepticus. Acta Neurol Scand 2011 Feb;123(2):137–41. https://doi.org/10.1111/j.16000404.2010.01423.x PMID:20868429 6. Miró J, Toledo M, Santamarina E, Ricciardi AC, Villanueva V, Pato A et al. Efficacy of intravenous lacosamide as an add-on treatment in refractory status epilepticus: a multicentric prospective study. Seizure 2013 Jan;22(1):77–9. https://doi.org/10.1016/j.seizure.2012.10.004 PMID:23127776 7. Grosso S, Zamponi N, Bartocci A, Cesaroni E, Cappanera S, Di Bartolo R, et al. Lacosamide in children with refractory status epilepticus. A multicenter Italian experience. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 2014;18(5):604-8. https://doi.org/10.1016/j.ejpn.2014.04.013. PMID: 24836405.

Pediatric Neurology Briefs 2017;31(2):5. http://dx.doi.org/10.15844/pedneurbriefs-31-2-2 ISSN: 1043-3155 (print) 2166-6482 (online). Received 2017 Jan 1. Accepted 2017 Jan 14. Published 2017 Feb 1. ©2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License.

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Lacosamide in Pediatric Status Epilepticus.

Investigators from Baylor College of Medicine studied the efficacy of lacosamide in pediatric status epilepticus (SE)...
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