JOURNAL OF PATHOLOGY, VOL.

168: 179-1 85 (1992)

KiSl-A NOVEL MONOCLONAL ANTIBODY WHICH RECOGNIZES PROLIFERATING CELLS: EVALUATION OF ITS RELATIONSHIP TO PROGNOSIS IN MAMMARY CARCINOMA STEVEN A. SAMPSON*, HANS K R E I P E ~ ,CHERYL E. GILLETT~,PAUL SMITH?, MURID A. CHAUDARY?, ASHRAF KHAN*, KIMBERLY WICKS?, R. PARWARESCH~AND DIANA M. BARNES?

*Department of Histopathology, UMDS and TICRF Clinical Oncology Unit, Guy's Hospital, London S E l 9 R T , U.K.; $Institute of Pathology, University of Kiel, Kiel, Germany Received 18 June 1992 Accepted 29 July 1992

SUMMARY Immunohistochemical staining with a novel monoclonal antibody, KiS 1, which recognizes a cell cycle-associated antigen, was investigated in 142 cases of stage I and I1 invasive breast carcinoma. KiSl staining indices were compared with disease-free interval, overall survival, and post-relapse survival. Using a semi-quantitative method of assessment, we found that tumours with a high level of staining (34/142,24 per cent) had a significantly worse prognosis than those with a low level of staining (108/142, 76 per cent). Significant correlations were found between KiSl staining and disease-free interval ( P < 0.001), overall survival (P

KiS1--a novel monoclonal antibody which recognizes proliferating cells: evaluation of its relationship to prognosis in mammary carcinoma.

Immunohistochemical staining with a novel monoclonal antibody, KiS1, which recognizes a cell cycle-associated antigen, was investigated in 142 cases o...
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