This article was downloaded by: [Selcuk Universitesi] On: 23 January 2015, At: 10:16 Publisher: Taylor & Francis Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Journal of Toxicology and Environmental Health, Part A: Current Issues Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/uteh20
Kidney Biomarkers Associated with Blood Lead, Mercury, and Cadmium in Premenopausal Women: A Prospective Cohort Study ab
a
a
a
c
Anna Z. Pollack , Sunni L. Mumford , Pauline Mendola , Neil J. Perkins , Yaron Rotman , d
a
Jean Wactawski-Wende & Enrique F. Schisterman a
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA b
Click for updates
Department of Global and Community Health, George Mason University, Fairfax, Virginia, USA c
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA d
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA Published online: 25 Nov 2014.
To cite this article: Anna Z. Pollack, Sunni L. Mumford, Pauline Mendola, Neil J. Perkins, Yaron Rotman, Jean WactawskiWende & Enrique F. Schisterman (2015) Kidney Biomarkers Associated with Blood Lead, Mercury, and Cadmium in Premenopausal Women: A Prospective Cohort Study, Journal of Toxicology and Environmental Health, Part A: Current Issues, 78:2, 119-131, DOI: 10.1080/15287394.2014.944680 To link to this article: http://dx.doi.org/10.1080/15287394.2014.944680
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http:// www.tandfonline.com/page/terms-and-conditions
Journal of Toxicology and Environmental Health, Part A, 78:119–131, 2015 Copyright © Taylor & Francis Group, LLC ISSN: 1528-7394 print / 1087-2620 online DOI: 10.1080/15287394.2014.944680
KIDNEY BIOMARKERS ASSOCIATED WITH BLOOD LEAD, MERCURY, AND CADMIUM IN PREMENOPAUSAL WOMEN: A PROSPECTIVE COHORT STUDY Anna Z. Pollack1,2, Sunni L. Mumford1, Pauline Mendola1, Neil J. Perkins1, Yaron Rotman3, Jean Wactawski-Wende4, Enrique F. Schisterman1
Downloaded by [Selcuk Universitesi] at 10:16 23 January 2015
1
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA 2 Department of Global and Community Health, George Mason University, Fairfax, Virginia, USA 3 Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA 4 Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA Certain metals are harmful to the kidney and liver at high levels, but associations with functional biomarkers at low exposure levels among premenopausal women apparently has not been evaluated. Healthy, regularly menstruating women (n = 259) were followed for up to 2 menstrual cycles with up to 16 visits. Renal and liver biomarkers were measured in serum at each clinic visit. Cadmium (Cd), lead (Pb), and mercury (Hg) were measured in whole blood at baseline. Linear mixed models were adjusted for age, body mass index (BMI), race, average calories, alcohol intake, smoking, and cycle day. Median levels of Cd, Pb, and Hg were 0.31 µg/L, 0.88 µg/dl, and 1.1 µg/L, respectively. One-third of women had diminished glomerular filtration rate (eGFR) (
Journal of Toxicology and Environmental Health, Part A: Current Issues Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/uteh20
Kidney Biomarkers Associated with Blood Lead, Mercury, and Cadmium in Premenopausal Women: A Prospective Cohort Study ab
a
a
a
c
Anna Z. Pollack , Sunni L. Mumford , Pauline Mendola , Neil J. Perkins , Yaron Rotman , d
a
Jean Wactawski-Wende & Enrique F. Schisterman a
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA b
Click for updates
Department of Global and Community Health, George Mason University, Fairfax, Virginia, USA c
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA d
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA Published online: 25 Nov 2014.
To cite this article: Anna Z. Pollack, Sunni L. Mumford, Pauline Mendola, Neil J. Perkins, Yaron Rotman, Jean WactawskiWende & Enrique F. Schisterman (2015) Kidney Biomarkers Associated with Blood Lead, Mercury, and Cadmium in Premenopausal Women: A Prospective Cohort Study, Journal of Toxicology and Environmental Health, Part A: Current Issues, 78:2, 119-131, DOI: 10.1080/15287394.2014.944680 To link to this article: http://dx.doi.org/10.1080/15287394.2014.944680
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http:// www.tandfonline.com/page/terms-and-conditions
Journal of Toxicology and Environmental Health, Part A, 78:119–131, 2015 Copyright © Taylor & Francis Group, LLC ISSN: 1528-7394 print / 1087-2620 online DOI: 10.1080/15287394.2014.944680
KIDNEY BIOMARKERS ASSOCIATED WITH BLOOD LEAD, MERCURY, AND CADMIUM IN PREMENOPAUSAL WOMEN: A PROSPECTIVE COHORT STUDY Anna Z. Pollack1,2, Sunni L. Mumford1, Pauline Mendola1, Neil J. Perkins1, Yaron Rotman3, Jean Wactawski-Wende4, Enrique F. Schisterman1
Downloaded by [Selcuk Universitesi] at 10:16 23 January 2015
1
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA 2 Department of Global and Community Health, George Mason University, Fairfax, Virginia, USA 3 Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA 4 Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA Certain metals are harmful to the kidney and liver at high levels, but associations with functional biomarkers at low exposure levels among premenopausal women apparently has not been evaluated. Healthy, regularly menstruating women (n = 259) were followed for up to 2 menstrual cycles with up to 16 visits. Renal and liver biomarkers were measured in serum at each clinic visit. Cadmium (Cd), lead (Pb), and mercury (Hg) were measured in whole blood at baseline. Linear mixed models were adjusted for age, body mass index (BMI), race, average calories, alcohol intake, smoking, and cycle day. Median levels of Cd, Pb, and Hg were 0.31 µg/L, 0.88 µg/dl, and 1.1 µg/L, respectively. One-third of women had diminished glomerular filtration rate (eGFR) (
