European Journal of Heart Failure (2015) 17, 535 doi:10.1002/ejhf.301

June 2015 at a glance Marco Metra

Recommendations and state of the heart articles This issue of the journal includes the new recommendations on management of acute heart failure (HF).1 This is a joint effort of the Heart Failure Association of the European Society of Cardiology (ESC), the European Society of Emergency Medicine and the Society of Academic Emergency Medicine. Recommendations about prehospital and hospital management, personnel involved, medications and discharge criteria are given.1 In addition to natriuretic peptides, an armamentarium of new biomarkers related with myocardial cell loss, fibrosis, infection and renal function have been introduced for HF patients. A state of the art review about new biomarkers in HF shows the best emerging candidates for the clinical assessment and management of patients with HF.2

Epidemiology Four articles are related with the epidemiology of HF. A report from the EURObservational Research Programme Pilot survey on Atrial Fibrillation shows the characteristics and prognosis of the patients with atrial fibrillation and HF. An analysis of the national trends in rate of patients hospitalized for HF and HF mortality in France, 2000–2012 shows, using data from the French National Hospitalization and national Mortality Databases, a slight decrease in HF hospitalizations in men, but not in women, and an overall decrease in HF mortality by 3.3% per year, larger, also in this case, in men than in women. Despite this improvement, HF remains a leading cause of hospitalizations and death.3 ExtraHF, the first European survey on implementation of exercise training in HF patients shows that an exercise training program is still not implemented by 67/170 (40%) cardiac centers with lack of resources as the most important cause.4 Marked geographical differences among patients hospitalized for HF in the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) are shown with annual mortality rates ranging from 7.3% in North America to 26.7% in Asia/Pacific, a difference largely driven by sudden cardiac death, and annual HF hospitalizations rates ranging from 22.7% in Latin America to 43.9% in North America.5

Comorbidities: dementia Dementia is probably one of the most important and of the least studied comorbidities of HF. In this issue of the journal, the different


Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy

© 2015 The Authors European Journal of Heart Failure © 2015 European Society of Cardiology

types of HF, mostly HF with preserved ejection fraction, and of dementia, mostly vascular, and the lack of prognostic impact of dementia are shown by an analysis of linked Swedish HF and dementia registries.6

A nurse-led intervention Stewart et al. present a nurse-led secondary prevention programme to prevent HF in high-risk individuals. This study was a pragmatic, single-centre, open-label, randomized controlled trial with blinded endpoint adjudication performed in 624 cardiac inpatients at risk for development of HF.7 During 51 ± 8 months of follow-up, there were no differences in the rate of de novo HF hospitalization or all-cause mortality (primary endpoint) with, however, fewer days of hospitalization and a better cardiac recovery on echocardiography at 3 years in the intervention group.7

References 1. Mebazaa A YM, Levy P, Ponikowski P, Peacock WF, Laribi S, Ristic A, Lambrinou E, Masip J, Riley JP, McDonagh T, Mueller C, deFilippi C, Harjola V, Thiele H, Piepoli MF, Metra M, Maggioni A, McMurray J, Dickstein K, Damman K, Seferovic PM, Ruschitzka F, Leite-Moreira AF, Bellou A, Anker SD, Filippatos G. Recommendations on pre-hospital and hospital management of acute heart failure: A consensus paper fromthe heart failure association of the european society of cardiology, the european society of emergency medicine and the society of academic emergency medicine. European journal of heart failure. 2015;17 2. de Boer RA, Daniels LB, Maisel AS, Januzzi JL, Jr. State of the art: Newer biomarkers in heart failure. European journal of heart failure. 2015 3. Gabet A, Juilliere Y, Lamarche-Vadel A, Vernay M, Olie V. National trends in rate of patients hospitalized for heart failure and heart failure mortality in france, 2000–2012. European journal of heart failure. 2015 4. Piepoli MF, Binno S, Corra U, Seferovic P, Conraads V, Jaarsma T, Schmid JP, Filippatos G, Ponikowski PP, Committee on Exercise P, Training of the Heart Failure Association of the ESC. Extrahf survey: The first european survey on implementation of exercise training in heart failure patients. European journal of heart failure. 2015 5. Greene SJ, Fonarow GC, Solomon SD, Subacius H, Maggioni AP, Bohm M, Lewis EF, Zannad F, Gheorghiade M, Investigators A, Coordinators. Global variation in clinical profile, management, and post-discharge outcomes among patients hospitalized for worsening chronic heart failure: Findings from the astronaut trial. European journal of heart failure. 2015 6. Cermakova P, Lund LH, Fereshtehnejad SM, Johnell K, Winblad B, Dahlstrom U, Eriksdotter M, Religa D. Heart failure and dementia: Survival in relation to types of heart failure and different dementia disorders. European journal of heart failure. 2015 7. Stewart S, Chan YK, Wong C, Jennings G, Scuffham P, Esterman A, Carrington M, Investigators N-C. Impact of a nurse-led home and clinic-based secondary prevention programme to prevent progressive cardiac dysfunction in high-risk individuals: The nurse-led intervention for less chronic heart failure (nil-chf) randomized controlled study. European journal of heart failure. 2015

June 2015 at a glance.

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