Adverse Events of Cosmetic Dermatologic Procedures

Correction: This article was corrected on December 4, 2014, to fix an error in Table 4. REFERENCES 1. Brin MF, Boodhoo TI, Pogoda JM, et al. Safety and tolerability of onabotulinumtoxinA in the treatment of facial lines: a meta-analysis of individual patient data from global clinical registration studies in 1678 participants. J Am Acad Dermatol. 2009;61(6):961, e1-e11. doi:10.1016/j.jaad .2009.06.040. 2. Monheit GD, Cohen JL; Reloxin Investigational Group. Long-term safety of repeated administrations of a new formulation of botulinum toxin type A in the treatment of glabellar lines: interim analysis from an open-label extension study. J Am Acad Dermatol. 2009;61(3):421-425.

Original Investigation Research

3. Bass LS, Smith S, Busso M, McClaren M. Calcium hydroxylapatite (Radiesse) for treatment of nasolabial folds: long-term safety and efficacy results. Aesthet Surg J. 2010;30(2):235-238.

7. Wollina U, Konrad H. Managing adverse events associated with botulinum toxin type A: a focus on cosmetic procedures. Am J Clin Dermatol. 2005;6 (3):141-150.

4. Requena L, Requena C, Christensen L, Zimmermann US, Kutzner H, Cerroni L. Adverse reactions to injectable soft tissue fillers. J Am Acad Dermatol. 2011;64(1):1-36.

8. Sherling M, Friedman PM, Adrian R, et al. Consensus recommendations on the use of an erbium-doped 1,550-nm fractionated laser and its applications in dermatologic laser surgery. Dermatol Surg. 2010;36(4):461-469.

5. Sperling B, Bachmann F, Hartmann V, Erdmann R, Wiest L, Rzany B. The current state of treatment of adverse reactions to injectable fillers. Dermatol Surg. 2010;36(suppl 3):1895-1904.

9. Van Buren N, Alster TS. Laser treatment of dark skin: a review and update. J Drugs Dermatol. 2009; 8(9):821-827.

6. Ogden S, Griffiths TW. A review of minimally invasive cosmetic procedures. Br J Dermatol. 2008; 159(5):1036-1050.

NOTABLE NOTES

Jonathan Hutchinson The Greatest Syphilographer of All Time Ismaël Maatouk, MD; Roy Moutran, MD

Jonathan Hutchinson is recognized as the foremost British syphilologist of the 19th century. His interest in syphilis began early in his career, in 1849, when he described 2 cases of keratitis associated with congenital syphilis (CS).1 He realized later that very little had been written about CS.1 He had noted a peculiar development of the permanent teeth, particularly the upper incisors, in patients with CS.1 Hutchinson’s observation had been greeted with expressions of incredulity, so he decided to publish details of 13 cases followed later by details of 70 cases.1 At the same time, he published the results of his studies of the association between CS and interstitial keratitis. The old term strumous corneitis, which implied a connection with tuberculosis, was abandoned as meaningless in this context. Hutchinson's conclusion was a new idea, and for many years it was not accepted.1 In 1861, Hutchinson wrote an article on deafness accompanying CS, but he characterized it more fully in his Clinical Memoir (1863): it affects olderchildrenoradultsandiseventuallybilateral.Thus,“Hutchinson'striad” was complete and became a password in the profession, and at 35 years of age, Hutchinson became the specialist in the “'great imitator” as he named the disease. In 1876, he stated that syphilis was “a disease which could affect the skin and internal organs.”1 In 1879 he described how syphilis could mimic a multitude of skin, eye, and neurological disorders.1 In 1887, 18 years before Treponema pallidum was discovered, Hutchinson stated that syphilis depends on a “living and specific microbe.”1 Hutchinson advocated mercury for the treatment of early syphilis; unlike many of his contemporaries, he believed that treatment should

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be started immediately after the diagnosis was made.1 He often combined iodides with mercury in cases of late syphilis. Hutchinson was doubtful of the value of organic arsenicals introduced by Ehrlich in 1906.2 Hutchinson’s study of individual case histories is shown in the first edition of his book Syphilis1 dedicated to Fournier. (The second edition, largely rewritten, appeared in 1909.2) It was probably his interest in syphilis that led him into the field of dermatology, ophthalmology and surgery.2 Hutchinson’s interest in museums arose from his ideas of objective teaching. At the British Medical Association meeting in 1868, he suggested that an annual exhibition of models be arranged to mark the year's progress. From this suggestion has arisen the system of scientific exhibit that is now a part of medical conventions. By his death in 1913, at the age of 85 he had been appointed as the chair of every important medical society in England. He had reached the top in ophthalmology, dermatology, and surgery, and history will probably pronounce him the greatest syphilographer of all time. Author Affiliations: Private practice (dermatologist, venereologist), Beirut, Lebanon (Maatouk); Department of Dermatology, Mount Lebanon Hospital, Beirut, Lebanon (Moutran). Corresponding Author: Ismaël Maatouk, MD, private practice (dermatologist, venereologist), Beirut, Lebanon ([email protected]). 1. Hutchinson J. Syphilis. London, England: Cassell & Co; 1887. 2. Hutchinson J. Syphilis. 2nd ed. London, England: Cassell & Co; 1909.

(Reprinted) JAMA Dermatology March 2015 Volume 151, Number 3

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Jonathan Hutchinson: the greatest syphilographer of all time.

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