J Chem Biol (2013) 6:207–213 DOI 10.1007/s12154-013-0105-6

JOCB BULLETIN

JOCB Bulletin Published online: 27 September 2013 # Springer-Verlag Berlin Heidelberg 2013

Thanks once again to all our readers who have submitted items for inclusion in this section. Can I remind you that we advertise readers’ items at the interface of the physical and life sciences free of charge including illustrations and colour. Any contributions that might be of interest to researchers in the Chemical Biology field concerning studentships, job vacancies courses or conferences, book reviews or news items would be most welcome. Please send to Dr C A Rosser 1 North Parade Derby DE1 3AY Email: [email protected]

GRADUATE STUDIES IN BILBAO, SPAIN

The University of the Basque Country offers Master and PhD degrees in Molecular Biology and Biomedicine. The one-year Master degree (60 ECTS) consists of lecture courses (30 ECTS) and a research project (30 ECTS). No knowledge of Spanish required. Info at: www.masterbiologiamolecular.ehu.es

Supervisor: Prof. J Trinick Department: Faculty of Biological Sciences Deadline: Applications accepted all year round Structure and function studies of isolated Z-discs from muscle The Z-disc is the anchoring structure for the ends of thin (actin) filaments and transmits contractile force between adjacent muscle sarcomeres. The primary linkages between thin filament ends of opposite polarity here are Z-bridges composed of α-actinin. In addition to have this purely mechanical function, the Z-disc is now known to contain ~40 different proteins and to have several other functions, particularly stress sensing into nuclear and proteolytic signalling pathways involving muscle growth and degradation. Because it has so far only been studied in the electron microscope in thin sections, the structure of the Z-disc is known only in outline, to a resolution of 4–5 nm, whereas ~2 nm resolution is required to recognise protein shapes and accurately dock crystal structures. To obtain 3D models with improved resolution, this project will study isolated Z-discs from both invertebrate and vertebrate muscle, including cardiac. Isolated Z-discs are also valuable for compositional studies, such as monitoring gain and loss of components that are transient in vivo. In addition to its fundamental importance in biology, this project will provide an excellent training in modern electron microscopy (cryo-tomography, image processing) as well as a wide variety of biochemical methods. Link: http://www.astbury.leeds.ac.uk/people/staffpage. php?StaffID=JT Email: [email protected]

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CoMPLEX is UCL’s centre for interdisciplinary research in the life sciences. The four-year interdisciplinary MRes + MPhil/PhD programme in Modelling Biological Complexity run by CoMPLEX, trains students to work at the interface between mathematics, engineering, physics, life and medical sciences. The programme is designed for students who wish to develop the skills to apply mathematical, computational and physical science techniques to real biological and medical problems. In this integrated programme, the first year is an MRes year during which students are trained in biological complexity, mathematical modelling of biological systems and advanced experimental techniques. Students will be involved in a range of interdisciplinary research projects that are dual supervised by one academic from mathematical/physical sciences and the other from the life and medical sciences. Link: http://www.ucl.ac.uk/complex E-mail: [email protected]

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implicated in numerous diseases so identification of E2–E3 pairs will provide new interaction surfaces for therapeutic targeting. Furthermore, determining the temporal dependence on E2–E3 pairings will also provide much sought insight into the mechanism of substrate ubiquitination. Using synthetic chemistry, genetic code expansion technology and cell biology methods this project will utilize sophisticated photocrosslinking technology allowing the determination of these transient E2–E3 complexes with temporal resolution. Applicants should have (or expect to obtain) at least the equivalent of a UK 2.1 honours degree (and preferably a Masters) in Chemistry, Biochemistry or other relevant discipline. Applications from students with either a strong chemical or biological science background are encouraged. This project would particularly suit a chemist wishing to broaden their expertise by working at the interface between chemistry and biology. Link: http://www.ppu.mrc.ac.uk/ Contact: [email protected]

School of Biosciences: PhD opportunity Supervisor: Dr. E I Hyde Co-supervisor: Dr. S A White Chemical biology approaches for the determination of ubiquitin signalling complexes Supervisor: Dr. S Virdee Dept: MRC Protein Phosphorylation and Ubiquitylation Unit Deadline: Applications accepted all year round Protein ubiquitination is a posttranslational modification which regulates almost all aspects of eukaryotic biology. Ubiquitin conjugation is orchestrated by ~40 E2 conjugating enzymes which operate in concert with several hundred E3 ligating enzymes giving rise to high combinatorial complexity. The combination of E2 and E3 enzyme influences the nature of the ubiquitin signal yet our understanding of which permutations are of physiological significance is surprisingly weak. The ubiquitin system is

Protein structure, function and kinetics: Use of NMR and other biophysical techniques to examine KorB, a protein controlling DNA-partitioning and gene regulation The student will be trained in a variety of biophysical methods, as well as protein purification and cloning. The methods developed and the conclusions from this study will be directly applicable to numerous proteins with disordered regions, which are involved in key functions such as cell signalling, regulation and cancer biology. Link: http://www.birmingham.ac.uk/staff/profiles/biosciences/ hyde-eva.aspx Email: [email protected]

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desire to apply these skills in the development of novel technologies.

Post Doctoral Researcher in Experimental Phasing for Macromolecular Crystallography Salary: Circa £33k Full time, three year fixed-term Ref: DIA0868/SB We are looking for a highly motivated researcher to develop innovative tools for automated experiment optimisation and ab initio phasing of macromolecular crystallography (MX) diffraction data sets. Diamond Light Source is the UK’s national synchrotron science facility. Located at Harwell Science and Innovation Campus in Oxfordshire, we enable world-leading research across a wide range of scientific disciplines and industrial applications. At Diamond Light Source we aim to deliver software that aligns with the rapid rate of data collection that can be achieved at our state of the art beamlines that exclusively use Pilatus detectors for MX data collection. This post is to extend our systems into automated ab initio structure solution, complementing the ongoing and future developments in data collection and processing. The successful candidate will join an experienced team of developers working on novel techniques for diffraction integration and automated methods for single and multi-crystal data processing, as well as collaborating with our peers at the Soleil synchrotron, France. Additionally the team work closely with a number of groups including CCP4. Deadline: 20th Oct 2013 Link: www.diamond.ac.uk

For more information or to apply for this opportunity, please email your CV and covering letter with salary details to [email protected]. Deadline: 30 December 2013 Link: http://www.base4.co.uk/recruitment/ Contact: Sarah Maciocci

As the premier international meeting in the field of cell biology, the ASCB Annual Meeting is intended for scientists and students in academia, industry, government, and higher education. Over 100 scientific sessions and 2,500 poster presentations cover a variety of scientific areas within the discipline. With opportunities to learn about the latest research and network with peers, the ASCB Annual Meeting appeals to the diverse interests of the international cell biology community.

Chemists/Physicists - Raman Spectroscopy Salary: £30,000 to £40,000 per Annum plus Benefits

The ASCB Annual Meeting is the place to:

Base4 is a fast-growing scientific startup company developing high-speed single molecule detection platforms for use in the biomedical industry. Founded in 2007, our focus is on the optimisation and rapid commercialisation of devices for DNA sequencing, point-of-care diagnostics and genetic analysis, along with novel approaches to sample preparation, data handling and bioinformatics. Due to our continuing expansion we are seeking highly motivated, team orientated and creative chemists and physicists to join our development team. Educated to PhD level, you will have significant knowledge and experience of Raman Spectroscopy and ideally Surface Enhanced Raman Spectroscopy (SERS), and a keen

& Hear and communicate cutting-edge science & Meet the leaders in the fields of cell biology, biophysics, stem cells, genomics… & Participate in intimate science discussion tables to learn from leaders in the field where science is going and how you should position yourself & Learn how to improve your PowerPoint presentations in sessions with professionals who have extensive TV and media experience & Take advantage of unprecedented training opportunities such as onsite CV review & Visit over 300 commercial and nonprofit exhibits offering new products and services

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& Improve teaching knowledge and skills & Recruit and/or interview job candidates & Attend sessions of special interest to students, minorities, and women & Learn where and how to apply, and advocate for, research funding Link: http://am.ascb.org/meetings/ Early Meeting Registration: 10 Oct 2013 Late Abstract Submission: 16 Oct 2012 Hotel Reservations: 21 Nov 2013

6th Biomedical Engineering International Conference (BMEiCON2013) 23–25 October 2013, Krabi Resort Hotel, Thailand The 6th Biomedical Engineering International Conference (BMEiCON2013) is intended to provide an international forum where researchers, practitioners, and professionals interested in the advances in, and applications of, biomedical engineering can exchange the latest research, results, and ideas in these areas through presentation and discussion. All presented papers will be submitted for inclusion in IEEE Xplore. Also selected papers are encouraged to publish in the International Journal of Applied Biomedical Engineering (IJABME). The BMEiCON2013 will be held in Krabi, Thailand, on October 23–25, 2013. & Biomedical signal processing & Biomedical imaging and image processing & Bioinstrumentation & Bio–robotics and biomechanics & Bio Informatics & Biosensors and Biomaterials & Cardiovascular and respiratory systems engineering & Cellular and Tissue Engineering & Cellular and Tissue Engineering & Human machine/computer interface & Medical device design & Neural and rehabilitation engineering & Technology commercialization, industry, education, and society & Telemedicine & Therapeutic and diagnostics systems & Recent advancements in biomedical engineering

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GEM / GERLI lipidomics meeting: from membranes to pathologies The “Groupe d’Etude des Membranes (GEM)” and the “Groupe d’Etude et de Recherche en Lipidomique (GERLI)” are two French societies with respective expertise in membrane biophysics and lipidomics. For the first time, they will organize a joint meeting (16th GEM/ 10th GERLI meeting) from November 10 to 14, 2013 in Saint-Jean-Cap-Ferrat, in the South-East of France. The specific aims of this meeting will be to discuss cuttingedge research on membrane components, ie lipids and membrane proteins, from their biophysical and biochemical properties to their specific functions in human physiology and therapeutic applications in pathological situations. http://www.gemgerli2013.fr/

Annual Symposium - Biochemical Determinants of Tissue Regeneration 11–13 December 2013 Shrigley Hall Hotel, Macclesfield, UK

Meeting background The field of regenerative medicine offers tantalising hope for the repair and replacement of damaged organs and tissues, with the ultimate goal of restoring normal tissue function. This field represents an enormous range of biological, chemical and biophysical technologies that harness the restorative properties of living materials, especially

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human cells, to produce new molecular and cellular medicines, diagnostics, devices and healthcare research tools. Link: http://www.biochemistry.org/Conferences/ AllConferences/tabid/379/View/Conference/Filter/4/ MeetingNo/SA153/Default.aspx Abstract deadline: 9 October 2013. Earlybird registration deadline: 11 November 2013.

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exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. A list of preliminary session topics and speakers is displayed below (discussion leaders, where known, are noted in italics). The detailed program is currently being developed by the Conference Chair and will be available by October 23, 2013. Please check back for updates.

February 15–19, 2014 Moscone Center, San Francisco, California Upcoming Dates: Abstract Submission Opens: July 1, 2013

Protons & Membrane Reactions - Connecting Membrane Protein Function with Structure February 23–28, 2014, Four Points Sheraton / Holiday Inn Express, Ventura, CA The 2014 Gordon Conference on Protons and Membrane Reactions will present cutting-edge research on the molecular structure and function of membrane proteins involved in the transport of protons and other ions. The Conference will feature a wide range of topics, such as the structure and function of proton channels, electron transport chain complexes, P-type ATPases, intramembrane proteases, and symporters. Invited speakers represent a variety of scientific disciplines, including biophysics, biochemistry, structural biology, and molecular dynamics simulations. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and

& Intramembrane Proteases & (Nicoleta Bondar / Sin Urban / Michael Wiener / TBA) & Opsins & (Janos Lanyi / Sergei Balashov / Joachim Heberle / TBA) & Electron Transport Chain Complexes & (Shelagh Ferguson-Miller / Marylyn Gunner / Ulrich Brandt / TBA) & NMR Approaches to Membrane Protein Structure and Function & (Mei Hong / Gerhard Wagner / Marc Baldus / TBA) & Protons in Channels & (Francesco Tombola / Scott Ramsay / Gerhard Fischer / TBA) & Symporters, Antiporters, and their Kin & (Robert Stroud / Bjørne Pedersen / Lan Guan / Christine Ziegler / TBA) & Theory and Simulations of Proton Reactions & (Douglas Tobias / Gerhard Hummer / Morton Jensen / TBA) & ATPases & (David Stokes / Brandy Akin / Todd Graham / Takeshi Murata / TBA) & Keynote Presentation: The Life and Times of Lac Permease / Junior Investigators Chosen from Poster Presentations & (Joseph Mindell / H. Ronald Kaback) Link: http://www.grc.org/programs.aspx?year=2014& program=protons Deadline: 26 Jan 2014

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12th Chemistry Conference for Young Scientists 27–28 february 2014, Blankenberge, Belgium. During ChemCYS young academic researchers will have the opportunity to present the results of their research through an oral or a poster presentation in English. The conference topics are organized in parallel sessions with common plenary lectures. The best oral and poster presentation of each session will be awarded by a jury of experts. The focus of this conference is quite broad with its aim to span the whole spectrum of chemistry: & Analytical and Environmental Chemistry & Biochemistry and -?technology & Inorganic Chemistry & Advanced Materials Chemistry & Organic and Medicinal Chemistry & Physical and Theoretical Chemistry The organizing committee is happy to announce that this edition of ChemCYS will be officially endorsed by the International Union of Pure and Applied Chemistry (IUPAC) and the European Association for Chemical and Molecular Sciences (EuCheMS).

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cooperate with each other, alter their programs of gene expression and fates, and reorganise themselves into a diversity of shapes and sizes. Most of these signalling pathways travel across cell membranes. Due to the advances in the analytical tools, which can be applied to membrane morphology, new opportunities exist now to understand these signalling mechanisms. Topics: & Membrane trafficking & Mechanism of membrane fusion and fission & Role of membrane domains in fission and fusion & Phosphoinositide signalling & Lipid signalling & Lipid phosphatase signalling & Lipid mass spectrometry of lipids & Autophagy & Phosphoinositide- dependent proteins & Advanced electron microscopy Proceedings (invited speakers) will be published in Biochemical Society Transactions. Link: http://www.biochemistry.org/Conferences/AllConferences/ tabid/379/View/Conference/Filter/4/MeetingNo/SA156/ Default.aspx Abstract deadline: 4 March 2014. Earlybird registration deadline: 7 April 2014.

Link: http://www.chemcys.be/ Deadline oral abstract submission: December 1, 2013 Deadline poster abstract submission: December 1, 2013 Deadline registration and payment: February 1, 2014

Membrane, Morphology and Function 5–8 May 2014 Hotel del Camerlengo, Fara San Martino, Abruzzo, Italy

Meeting background The functions of cells that lead to the exquisite processes of organismal development rely on communication. Signals are necessary for cells to communicate and

Euro Fed Lipid is a federation of 13 scientific associations concerned with Lipids, Fats and Oils. The federation represents 2000 individuals and companies. Its mission is the furthering of lipid science and technology and the cooperation and exchange of ideas between scientists and technologists at a European level. The activities of Euro Fed Lipid include the organisation of international congresses at varying venues, the co-organisation of the annual fair “oils + fats” and the publishing of the “European Journal of Lipid Science and Technology”.

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Main Topics/ Keynote Lectures: – Lipids in Animal Science – Biotechnology and Enzyme Technology – Molecular and Cellular Biology of Lipids in Health and Disease – Lipids in Nutrition – Lipidomics, Analytics, Authenticity, Imaging – Marine Lipids – Microbial Lipids – Lipid Chemistry and Oleochemistry – Mediterranean Oils and Fats

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– Palm Oil – Physical Chemistry, Lipid Biophysics and Formulations – Plant Lipids, Oil Seeds, Plant Breeding – Processing – Lipid Oxidation and Antioxidants – Milk and Dairy Products in Human Nutrition – Innovation in Industry – Young Scientists Session Link: www.eurofedlipid.org/index.php Deadline: details to follow

JOCB Bulletin.

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