JID VisualDx Quiz
JID VisualDx Quiz: May 2014 Tejas Patel1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2014) 134, e16. doi:10.1038/jid.2014.133
JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. What is your diagnosis? a. Pigmented basal cell carcinoma. b. Angiokeratoma. c. Melanoma. d. Spitz nevi. e. Inverse halo nevi.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
JID VisualDx Quiz
2. What is the highest level of clinical data supporting the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for patients with melanoma? a. Case reports. b. Case series. c. Retrospective cohort studies. d. Randomized controlled trials. e. Data do not exist.
3. Which is true regarding indomethacin and TRAIL in melanoma cells? a. Indomethacin causes TRAIL-induced apoptosis primarily via death receptor 4. b. Indomethacin’s effect on TRAIL-induced apoptosis is dependent on p53. c. I ndomethacin’s effect is completely mediated by downregulation of the antiapoptotic protein survivin. d. Induction of reactive oxygen species is important in indomethacin’s effect on TRAIL-induced apoptosis. e. All of the above.
TOPIC ARTICLE Questions 2 and 3 refer to the following article: Tse AK-W, Cao H-H, Cheng C-Y et al. (2013) Indomethacin sensitizes TRAIL-resistant melanoma cells to TRAIL-induced apoptosis through ROS-mediated upregulation of death receptor 5 and downregulation of survivin. J Invest Dermatol 134:1397–1407
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.133. Additional images related to this condition and the differential diagnosis may be found at: http://info.visualdx.com/l/11412/2014-03-11/vnc9k
2
Journal of Investigative Dermatology (2014), Volume 134
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
JID VisualDx Quiz: May 2014 Tejas Patel1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2014) 134, e16. doi:10.1038/jid.2014.133
JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. What is your diagnosis? a. Pigmented basal cell carcinoma. b. Angiokeratoma. c. Melanoma. d. Spitz nevi. e. Inverse halo nevi.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
JID VisualDx Quiz
2. What is the highest level of clinical data supporting the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for patients with melanoma? a. Case reports. b. Case series. c. Retrospective cohort studies. d. Randomized controlled trials. e. Data do not exist.
3. Which is true regarding indomethacin and TRAIL in melanoma cells? a. Indomethacin causes TRAIL-induced apoptosis primarily via death receptor 4. b. Indomethacin’s effect on TRAIL-induced apoptosis is dependent on p53. c. I ndomethacin’s effect is completely mediated by downregulation of the antiapoptotic protein survivin. d. Induction of reactive oxygen species is important in indomethacin’s effect on TRAIL-induced apoptosis. e. All of the above.
TOPIC ARTICLE Questions 2 and 3 refer to the following article: Tse AK-W, Cao H-H, Cheng C-Y et al. (2013) Indomethacin sensitizes TRAIL-resistant melanoma cells to TRAIL-induced apoptosis through ROS-mediated upregulation of death receptor 5 and downregulation of survivin. J Invest Dermatol 134:1397–1407
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.133. Additional images related to this condition and the differential diagnosis may be found at: http://info.visualdx.com/l/11412/2014-03-11/vnc9k
2
Journal of Investigative Dermatology (2014), Volume 134
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
