JID VisualDx Quiz

JID VisualDx Quiz: July 2014 Alexander Badiavas1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2014) 134, e18. doi:10.1038/jid.2014.214

JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.

Image appears with permission from VisualDx. © Logical Images, Inc.

QUESTIONS 1.  What is your diagnosis?  a.  Systemic sclerosis.  b.  Graft-versus-host disease.  c.  Scleredema.  d.  Morphea.  e.  Nephrogenic systemic fibrosis.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA

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© 2014 The Society for Investigative Dermatology

www.jidonline.org

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JID VisualDx Quiz

2. Benefits of skin-specific ablation of mast cells (compared with other models of mast-cell elimination) include the following (choose all that apply):   a.  Superior removal of all mast cells.   b.  Clarification of contradictory results of other mast-cell models.   c.  Ability to examine skin-specific effects of mast cells.   d.  Allows examination of mast-cell trafficking.  e.  All of the above.

3. Based on the above work, which is true about the role of mast cells in repair?  a.  Critical for wound healing.  b.  Possibly needed but redundancy exists.  c.  Without mast cells scarring is prevented.  d.  Without mast cells scarring is increased.  e.  None of the above.

TOPIC ARTICLE Questions 2 and 3 refer to the following article: Willenborg S, Eckes B, Brinckmann J et al. (2014) Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis. J Invest Dermatol 134:2005–15

Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.214. Additional images related to this condition and the differential diagnosis may be found at http://info.visualdx.com/l/11412/2014-05-02/vx3yw.

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Journal of Investigative Dermatology (2014), Volume 134

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JID VisualDx quiz: July 2014. Graft-versus-host disease.

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