JID VisualDx Quiz

JID VisualDx Quiz: February 2015 Anna Nichols1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2015) 135, e25. doi:10.1038/jid.2014.496

JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.

Image appears with permission from VisualDx. © Logical Images, Inc.

QUESTIONS 1. What is your diagnosis? a. Psoriasis. b.

Cutaneous T-cell lymphoma (CTCL).


Drug reaction.


Large-plaque parapsoriasis.

e. Syphilis.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA


© 2015 The Society for Investigative Dermatology



JID VisualDx Quiz

2. Which pathway is a potential target for CTCL? (choose all that apply) a.

Protein kinase C-b (PKCb).


Mitogen-activated protein kinase (MAPK).


Glycogen synthase kinase-3 (GSK3).


T-cell receptor (TCR).


All of the above.

3. Inhibition of which of the below leads to increased cell death of atypical lymphocytes? (choose all that apply) a. p38. b. p63. c. p53. d. Rb. e.

All of the above.

TOPIC ARTICLE Questions 2 and 3 refer to the following article: Bliss-Moreau M, Coarfa C, Gunaratne PH et al. (2015) Identification of p38b as a therapeutic target for the treatment of Sézary syndrome. J Invest Dermatol 135:599–608

Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.496.


Journal of Investigative Dermatology (2015), Volume 135

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JID VisualDx Quiz: February 2015.

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