JID VisualDx Quiz

JID VisualDx Quiz: August 2014 Alexander Badiavas1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2014) 134, e19. doi:10.1038/jid.2014.239

JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.

Image appears with permission from VisualDx. © Logical Images, Inc.

QUESTIONS 1.  What is your diagnosis?  a.  Pemphigus foliaceus.  b.  Pemphigus vulgaris.  c.  Staphylococcal scaled skin syndrome.  d.  Toxic epidermal necrolysis.  e.  Seborrheic dermatitis.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA

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© 2014 The Society for Investigative Dermatology

www.jidonline.org

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JID VisualDx Quiz

2.  UV light is associated with which of the following?   a.  Worsening of pemphigus.   b.  Activation of lupus erythematosus.   c.  Upregulation of desmoglein proteins.   d.  Decreased all-cause mortality.  e.  All of the above.

3. Based on the work cited below, which is true about the role of desmoglein in epithelial repair?  a.  It is reduced by UV light.  b.  It plays a role in cell adhesion.  c.  It is restored by trichostatin A.  d.  It increases expression of desmocollin.  e.  All of the above.

TOPIC ARTICLE Questions 2 and 3 refer to the following article: Johnson JL, Koetsier JL, Sirico A et al. (2014) The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. J Invest Dermatol 134:2154–62

Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.239. Additional images related to this condition and the differential diagnosis may be found at http://info.visualdx.com /l/11412/2014-05-27/w1krp

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Journal of Investigative Dermatology (2014), Volume 134

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JID VisualDx Quiz: August 2014: pemphigus foliaceus.

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