Eur J Pediatr DOI 10.1007/s00431-014-2486-0
CORRESPONDENCE
Is vitamin D deficiency alone sufficient to increase the incidence of neonatal sepsis? Kadir Şerafettin Tekgündüz & Handan Alp & Mevlüt Kürşat Akkar
Received: 18 December 2014 / Accepted: 29 December 2014 # Springer-Verlag Berlin Heidelberg 2015
Dear Editor, We read with great interest the manuscript of Cizmeci et al. [1] entitled “Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: a case– control study from a tertiary care center in Turkey.” In that study, out of the 83 infants, 40 were suspected of having early-onset neonatal sepsis (EONS) (study group) and 43 had no sepsis (control group).They reported that low cord blood 25-OHD status of 2500 g. The mean vitamin D level of the neonates was 7.0 ± 6.6 ng/ml. The subjects were divided into five groups according to their vitamin D levels (Table 1). We did not observe EONS in either of our study groups. In conclusion, if neonatal sepsis does not increase in healthy neonates with lower vitamin D levels, as in our study, then other factors associated with pregnancy might play a role in EONS. Therefore, we believe that further large, controlled, and randomized studies are needed to evaluate the role that vitamin D plays in EONS.
Communicated by Patrick Van Reempts
Table 1
This paper is a correspondence to http://dx.doi.org/10.1007/s00431-0142469-1.
Vitamin D Levels
Number of Neonates (%)
K. Ş. Tekgündüz (*) Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Atatürk University, 25240 Erzurum, Turkey e-mail: [email protected]
Severe deficiency (
CORRESPONDENCE
Is vitamin D deficiency alone sufficient to increase the incidence of neonatal sepsis? Kadir Şerafettin Tekgündüz & Handan Alp & Mevlüt Kürşat Akkar
Received: 18 December 2014 / Accepted: 29 December 2014 # Springer-Verlag Berlin Heidelberg 2015
Dear Editor, We read with great interest the manuscript of Cizmeci et al. [1] entitled “Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: a case– control study from a tertiary care center in Turkey.” In that study, out of the 83 infants, 40 were suspected of having early-onset neonatal sepsis (EONS) (study group) and 43 had no sepsis (control group).They reported that low cord blood 25-OHD status of 2500 g. The mean vitamin D level of the neonates was 7.0 ± 6.6 ng/ml. The subjects were divided into five groups according to their vitamin D levels (Table 1). We did not observe EONS in either of our study groups. In conclusion, if neonatal sepsis does not increase in healthy neonates with lower vitamin D levels, as in our study, then other factors associated with pregnancy might play a role in EONS. Therefore, we believe that further large, controlled, and randomized studies are needed to evaluate the role that vitamin D plays in EONS.
Communicated by Patrick Van Reempts
Table 1
This paper is a correspondence to http://dx.doi.org/10.1007/s00431-0142469-1.
Vitamin D Levels
Number of Neonates (%)
K. Ş. Tekgündüz (*) Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Atatürk University, 25240 Erzurum, Turkey e-mail: [email protected]
Severe deficiency (
