Accepted Manuscript In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography Abtin Shahlaee, MD, Wasim A. Samara, MD, Jason Hsu, MD, Emil Anthony T. Say, MD, M. Ali Khan, MD, Jayanth Sridhar, MD, Bryan K. Hong, MD, Carol L. Shields, MD, Allen C. Ho, MD PII:
S0002-9394(16)30068-X
DOI:
10.1016/j.ajo.2016.02.018
Reference:
AJOPHT 9633
To appear in:
American Journal of Ophthalmology
Received Date: 30 October 2015 Revised Date:
16 February 2016
Accepted Date: 17 February 2016
Please cite this article as: Shahlaee A, Samara WA, Hsu J, Say EAT, Khan MA, Sridhar J, Hong BK, Shields CL, Ho AC, In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography, American Journal of Ophthalmology (2016), doi: 10.1016/ j.ajo.2016.02.018. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Abstract PURPOSE: To quantify density of macular vascular networks over regions of interest in healthy subjects using optical coherence tomography angiography (OCTA).
RI PT
DESIGN: Prospective cross-sectional study. METHODS: Settings: Retina and Oncology Services of Wills Eye Hospital.
SC
Subjects with no known systemic disease and without retinal pathology were included. OCTA was performed on a 3×3-mm region centered on the macula (RTVue-XR Avanti, Optovue) and en face angiograms of the superficial and deep vascular networks were acquired. Vascular density was calculated using an automated image thresholding method (ImageJ, National Institutes of Health) over regions of interest.
M AN U
Foveal and parafoveal vascular density were calculated. The differences between vascular networks, genders, fellow eyes and correlation between vascular density, signal strength, and age as well as reproducibility of measurements were evaluated.
TE D
RESULTS: A total of 198 healthy eyes were imaged from which 163 eyes of 122 subjects were included based on image quality criteria. In the parafoveal region, deep vascular density was significantly higher than the superficial (52±2.4% vs. 46±2.2%; P
S0002-9394(16)30068-X
DOI:
10.1016/j.ajo.2016.02.018
Reference:
AJOPHT 9633
To appear in:
American Journal of Ophthalmology
Received Date: 30 October 2015 Revised Date:
16 February 2016
Accepted Date: 17 February 2016
Please cite this article as: Shahlaee A, Samara WA, Hsu J, Say EAT, Khan MA, Sridhar J, Hong BK, Shields CL, Ho AC, In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography, American Journal of Ophthalmology (2016), doi: 10.1016/ j.ajo.2016.02.018. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Abstract PURPOSE: To quantify density of macular vascular networks over regions of interest in healthy subjects using optical coherence tomography angiography (OCTA).
RI PT
DESIGN: Prospective cross-sectional study. METHODS: Settings: Retina and Oncology Services of Wills Eye Hospital.
SC
Subjects with no known systemic disease and without retinal pathology were included. OCTA was performed on a 3×3-mm region centered on the macula (RTVue-XR Avanti, Optovue) and en face angiograms of the superficial and deep vascular networks were acquired. Vascular density was calculated using an automated image thresholding method (ImageJ, National Institutes of Health) over regions of interest.
M AN U
Foveal and parafoveal vascular density were calculated. The differences between vascular networks, genders, fellow eyes and correlation between vascular density, signal strength, and age as well as reproducibility of measurements were evaluated.
TE D
RESULTS: A total of 198 healthy eyes were imaged from which 163 eyes of 122 subjects were included based on image quality criteria. In the parafoveal region, deep vascular density was significantly higher than the superficial (52±2.4% vs. 46±2.2%; P
