HHS Public Access Author manuscript Author Manuscript
Obesity (Silver Spring). Author manuscript; available in PMC 2017 August 01. Published in final edited form as: Obesity (Silver Spring). 2016 August ; 24(8): 1731–1740. doi:10.1002/oby.21557.
Inverse association between carbohydrate consumption and plasma adropin concentrations in humans Joseph R. Stevens1, Monica L. Kearney2, Marie-Pierre St-Onge3, Kimber L. Stanhope4, Peter J. Havel4, Jill A. Kanaley2, John P. Thyfault5, Edward P. Weiss6, and Andrew A. Butler1 1Department
of Pharmacology and Physiology, Saint Louis University School of Medicine, St.
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Louis, MO 2Department
of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
3New
York Obesity Research Center, Department of Medicine; Institute of Human Nutrition, Columbia University, New York, NY, USA 4Department
of Molecular Biosciences, School of Veterinary Medicine; Department of Nutrition, School of Medicine, University of California-Davis, Davis, CA
5Department
of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS
6Department
of Nutrition and Dietetics, Doisy College of Health Sciences of Saint Louis University, St. Louis, MO
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Abstract Objective—The role of metabolic condition and diet in regulating circulating levels of adropin, a peptide hormone linked to cardiometabolic control, is not well understood. Here we examined weight loss and diet effects on plasma adropin concentrations. Methods—The present report includes data from (1) a weight loss trial, (2) an evaluation of acute exercise effects on mixed-meal tolerance test responses, and (3) a meta-analysis to determine normal fasting adropin concentrations.
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Results—Plasma adropin concentrations exhibit a distribution with positive skew and kurtosis. The effect of weight loss on plasma adropin concentrations was dependent on baseline plasma adropin concentrations, with an inverse association between baseline and a decline in concentrations after weight loss (Spearman’s ρ=−0.575; P30 min; not employed in physically active jobs or hobbies) weight stable, overweight and obese [body mass index (BMI) 25.0–37.0 kg/m2] male (n=2) and female (n=7) subjects aged 48–67y with physician-diagnosed type 2 diabetes (T2D) and HbA1c