Introduction to the Symposium Proceedings F. Scannapieco
•• Chunhao Li (University at Buffalo), Sialidase, Red-complex bacteria, and periodontitis.
Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Foster Hall, Buffalo, NY 14214-3092, USA; [email protected]
Session 2 – Immunology (Moderator – Ernesto DeNardin)
Adv Dent Res 26(1):2-3, 2014
This article summarizes information presented during the 50th Anniversary of the University at Buffalo Oral Biology Graduate Program, which took place June 12-14, 2013, in Buffalo, New York. Sponsored by Sunstar Americas Inc.
•• Martin Taubman (Forsyth Institute), Is there a role for passive immunity in the treatment of periodontal disease? •• Sarah Gaffen (University of Pittsburgh), Straight from the mouse’s mouth: IL-17 and Th17 cells in oral candidiasis. •• Mark Herzberg (University of Minnesota), Augmenting innate epithelial immunity using a shortcut through the dogma and the trinity.
T
Session 3 – Saliva (Moderator – Michael Levine)
he University at Buffalo School of Dental Medicine established the first Department of Oral Biology in the United States in 1960. Three years later, UB created the first PhD program in oral biology in a dental school. For 50 years, the Graduate Program in Oral Biology at the University at Buffalo has trained more than 80 PhD students and numerous post-doctoral fellows, dental and college students, and visiting professors in modern techniques and concepts pertinent to oral health research. Many of these individuals have gone on to make important contributions in research areas such as oral microbiology, immunology, saliva and salivary glands, bone biology, radiation biology, periodontal biology, and the impact of oral diseases on a variety of systemic diseases. To celebrate the success of this program, a Symposium, “The Oral Microbiome, Immunity and Chronic Disease”, was held on June 12-14, 2013 at the Hotel @ The Lafayette in Buffalo, New York. A group of accomplished investigators – all present or former department faculty, students, or post-doctoral Fellows – were invited to present summaries of their recent research activities. This issue of Advances in Dental Research presents summary papers that are organized along the lines of each of the symposium sessions:
•• Olga Baker (University at Buffalo), New approaches to treat salivary gland dysfunction. •• Stefan Ruhl (University at Buffalo), The salivary proteomeoral microbiome interface. •• Mira Edgerton (University at Buffalo), Designer drugs – modification of salivary histatin as a therapeutic for oral candidiasis.
Session 4 – Periodontal and Oral Medicine (Moderator – Robert Schifferle) •• Bruno Loos (ACTA, the Netherlands), Periodontitis and cardiovascular disease: systemic and genetic conditions. •• Yiping Han (Case Western Reserve University), Fusobacterium nucleatum: a commensal turned pathogen. •• Jill Kramer (University at Buffalo), Autoantibodies and B-cell chemotaxis in Sjögren’s Syndrome.
Session 1 – Microbiology (Moderator – Joseph Zambon)
Session 5 – Periodontal Biology (Moderator – Moon-Il Cho)
•• Casey Chen (University of Southern California), Genomics and metagenomics of periodontal bacteria. •• Ashu Sharma (University at Buffalo), Tannerella forsythia and periodontitis. •• Atsuo Amano (Osaka University), Cellular membrane trafficking of intracellular P. gingivalis.
•• George Hajishengallis (University of Pennsylvania), Novel endogenous modulators of neutrophil recruitment and periodontitis.
Key Words dental plaque, salivary glands, periodontal pathogenesis, bone physiology, periodontal diseases, oral health.
DOI: 10.1177/0022034514525785 © International & American Associations for Dental Research
2 Downloaded from adr.sagepub.com by guest on November 13, 2015 For personal use only. No other uses without permission. © International & American Associations for Dental Research
Adv Dent Res 26(1) 2014
Introduction to the Symposium Proceedings 3
•• Yasuhiro Katsuragi (Sunstar), Effects of a calcium, vitamin D, and soy isoflavone dietary supplement on alveolar and skeletal bone loss in post-menopausal women. •• Harvey Schenkein (Virginia Commonwealth University), Antiphospholipids and molecular mimicry: a link between periodontitis and systemic disease?
of an NIH training grant, and establishment of the school’s research and graduate teaching programs. •• Robert Genco, the second chair of the department (1976 to 2002), who established an internationally recognized research program in periodontal biology and who continued to expand the PhD and other training programs.
Session 6 – Periodontal Biology (Moderator –Sebastian Ciancio)
In addition to these noteworthy individuals, the contributions of all who served as graduate program directors over the years deserve mention: Todd Evans, Mike Levine, Mark Wilson, Rosemary Dziak, Libuse Bobek, Frank Scannapieco, Sarah Gaffen, Mira Edgerton, and Ashu Sharma. Their dedicated and often-unsung efforts in the provision of research and career guidance ensured the success of all of the students who completed their training. Over the years a large group of dedicated departmental staff have capably assisted the faculty and students of the department. There are far too many to mention here, and I am sure I would inadvertently omit quite a few. I will take the time to praise the present staff: Dr. Kurt Winter, assistant to the chair, and department assistants Cathy Drdul, Debby Szurgyi, Iris Corchado, and Mary Carr, all of whom daily provide superb support for the program’s students and faculty. The Continuing Education Department of the University at Buffalo School of Dental Medicine, especially Annamarie Phalen and Linda Toplynyky, provided enormous and expert assistance to organize the symposium from its inception, and ably cared for all of the attendees. Ed Morrison provided important advice and assistance in the provision of documentation and promotion of the symposium. Ann Moulson provided expert and professional service in putting together the conference proceedings. Finally, the symposium would not have been successful without the generous support of Sunstar Americas Inc., which provided an unrestricted educational grant to the school for this event. Over the years, Sunstar has supported a number of innovative research projects, as well as training support for several “Sunstar Fellows.” Their vision and forward thinking in support of these activities are gratefully acknowledged.
•• Thomas Van Dyke (Forsyth Institute), Resolution of inflammation and the potential for control of inflammatory diseases. •• Mine Tezal (University at Buffalo), Periodontitis and head and neck cancer. •• S. Esra Sahingur (Virginia Commonwealth University), Microbial DNA sensing in periodontal inflammation.
Session 7 – Bone Biology (Moderator – Rosemary Dziak) •• Giuseppe Intini (Harvard University), Exploring the location and the molecular regulation of the intramembranous bone stem cell niche. •• Keith Kirkwood (Medical University of South Carolina), Innate immune signaling in periodontal inflammation and bone loss. •• Shuying Yang (University at Buffalo), The role of RGS proteins in the regulation of bone formation and remodeling. In addition, 35 posters were presented by present trainees. During the symposium banquet, three luminaries who made extraordinary contributions to the program were recognized: •• Ernest Hausmann, DMD, PhD, the first and only full-time researcher on the faculty in 1960. During the course of his career, Hausmann was one of the first to describe the direct action of microbial products such as lipopolysaccharides on bone destruction, and later developed computer-assisted measurement systems to measure alveolar bone height in periodontal disease. •• Solon “Art” Ellison, DDS, the founding chair of the department (1963 to 1976), who played an important role in recruitment of the founding faculty, initiation of the PhD program, the receipt
Acknowledgment The author received no financial support and declares no potential conflicts of interest with respect to the authorship and/or publication of this article.
Downloaded from adr.sagepub.com by guest on November 13, 2015 For personal use only. No other uses without permission. © International & American Associations for Dental Research
•• Chunhao Li (University at Buffalo), Sialidase, Red-complex bacteria, and periodontitis.
Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Foster Hall, Buffalo, NY 14214-3092, USA; [email protected]
Session 2 – Immunology (Moderator – Ernesto DeNardin)
Adv Dent Res 26(1):2-3, 2014
This article summarizes information presented during the 50th Anniversary of the University at Buffalo Oral Biology Graduate Program, which took place June 12-14, 2013, in Buffalo, New York. Sponsored by Sunstar Americas Inc.
•• Martin Taubman (Forsyth Institute), Is there a role for passive immunity in the treatment of periodontal disease? •• Sarah Gaffen (University of Pittsburgh), Straight from the mouse’s mouth: IL-17 and Th17 cells in oral candidiasis. •• Mark Herzberg (University of Minnesota), Augmenting innate epithelial immunity using a shortcut through the dogma and the trinity.
T
Session 3 – Saliva (Moderator – Michael Levine)
he University at Buffalo School of Dental Medicine established the first Department of Oral Biology in the United States in 1960. Three years later, UB created the first PhD program in oral biology in a dental school. For 50 years, the Graduate Program in Oral Biology at the University at Buffalo has trained more than 80 PhD students and numerous post-doctoral fellows, dental and college students, and visiting professors in modern techniques and concepts pertinent to oral health research. Many of these individuals have gone on to make important contributions in research areas such as oral microbiology, immunology, saliva and salivary glands, bone biology, radiation biology, periodontal biology, and the impact of oral diseases on a variety of systemic diseases. To celebrate the success of this program, a Symposium, “The Oral Microbiome, Immunity and Chronic Disease”, was held on June 12-14, 2013 at the Hotel @ The Lafayette in Buffalo, New York. A group of accomplished investigators – all present or former department faculty, students, or post-doctoral Fellows – were invited to present summaries of their recent research activities. This issue of Advances in Dental Research presents summary papers that are organized along the lines of each of the symposium sessions:
•• Olga Baker (University at Buffalo), New approaches to treat salivary gland dysfunction. •• Stefan Ruhl (University at Buffalo), The salivary proteomeoral microbiome interface. •• Mira Edgerton (University at Buffalo), Designer drugs – modification of salivary histatin as a therapeutic for oral candidiasis.
Session 4 – Periodontal and Oral Medicine (Moderator – Robert Schifferle) •• Bruno Loos (ACTA, the Netherlands), Periodontitis and cardiovascular disease: systemic and genetic conditions. •• Yiping Han (Case Western Reserve University), Fusobacterium nucleatum: a commensal turned pathogen. •• Jill Kramer (University at Buffalo), Autoantibodies and B-cell chemotaxis in Sjögren’s Syndrome.
Session 1 – Microbiology (Moderator – Joseph Zambon)
Session 5 – Periodontal Biology (Moderator – Moon-Il Cho)
•• Casey Chen (University of Southern California), Genomics and metagenomics of periodontal bacteria. •• Ashu Sharma (University at Buffalo), Tannerella forsythia and periodontitis. •• Atsuo Amano (Osaka University), Cellular membrane trafficking of intracellular P. gingivalis.
•• George Hajishengallis (University of Pennsylvania), Novel endogenous modulators of neutrophil recruitment and periodontitis.
Key Words dental plaque, salivary glands, periodontal pathogenesis, bone physiology, periodontal diseases, oral health.
DOI: 10.1177/0022034514525785 © International & American Associations for Dental Research
2 Downloaded from adr.sagepub.com by guest on November 13, 2015 For personal use only. No other uses without permission. © International & American Associations for Dental Research
Adv Dent Res 26(1) 2014
Introduction to the Symposium Proceedings 3
•• Yasuhiro Katsuragi (Sunstar), Effects of a calcium, vitamin D, and soy isoflavone dietary supplement on alveolar and skeletal bone loss in post-menopausal women. •• Harvey Schenkein (Virginia Commonwealth University), Antiphospholipids and molecular mimicry: a link between periodontitis and systemic disease?
of an NIH training grant, and establishment of the school’s research and graduate teaching programs. •• Robert Genco, the second chair of the department (1976 to 2002), who established an internationally recognized research program in periodontal biology and who continued to expand the PhD and other training programs.
Session 6 – Periodontal Biology (Moderator –Sebastian Ciancio)
In addition to these noteworthy individuals, the contributions of all who served as graduate program directors over the years deserve mention: Todd Evans, Mike Levine, Mark Wilson, Rosemary Dziak, Libuse Bobek, Frank Scannapieco, Sarah Gaffen, Mira Edgerton, and Ashu Sharma. Their dedicated and often-unsung efforts in the provision of research and career guidance ensured the success of all of the students who completed their training. Over the years a large group of dedicated departmental staff have capably assisted the faculty and students of the department. There are far too many to mention here, and I am sure I would inadvertently omit quite a few. I will take the time to praise the present staff: Dr. Kurt Winter, assistant to the chair, and department assistants Cathy Drdul, Debby Szurgyi, Iris Corchado, and Mary Carr, all of whom daily provide superb support for the program’s students and faculty. The Continuing Education Department of the University at Buffalo School of Dental Medicine, especially Annamarie Phalen and Linda Toplynyky, provided enormous and expert assistance to organize the symposium from its inception, and ably cared for all of the attendees. Ed Morrison provided important advice and assistance in the provision of documentation and promotion of the symposium. Ann Moulson provided expert and professional service in putting together the conference proceedings. Finally, the symposium would not have been successful without the generous support of Sunstar Americas Inc., which provided an unrestricted educational grant to the school for this event. Over the years, Sunstar has supported a number of innovative research projects, as well as training support for several “Sunstar Fellows.” Their vision and forward thinking in support of these activities are gratefully acknowledged.
•• Thomas Van Dyke (Forsyth Institute), Resolution of inflammation and the potential for control of inflammatory diseases. •• Mine Tezal (University at Buffalo), Periodontitis and head and neck cancer. •• S. Esra Sahingur (Virginia Commonwealth University), Microbial DNA sensing in periodontal inflammation.
Session 7 – Bone Biology (Moderator – Rosemary Dziak) •• Giuseppe Intini (Harvard University), Exploring the location and the molecular regulation of the intramembranous bone stem cell niche. •• Keith Kirkwood (Medical University of South Carolina), Innate immune signaling in periodontal inflammation and bone loss. •• Shuying Yang (University at Buffalo), The role of RGS proteins in the regulation of bone formation and remodeling. In addition, 35 posters were presented by present trainees. During the symposium banquet, three luminaries who made extraordinary contributions to the program were recognized: •• Ernest Hausmann, DMD, PhD, the first and only full-time researcher on the faculty in 1960. During the course of his career, Hausmann was one of the first to describe the direct action of microbial products such as lipopolysaccharides on bone destruction, and later developed computer-assisted measurement systems to measure alveolar bone height in periodontal disease. •• Solon “Art” Ellison, DDS, the founding chair of the department (1963 to 1976), who played an important role in recruitment of the founding faculty, initiation of the PhD program, the receipt
Acknowledgment The author received no financial support and declares no potential conflicts of interest with respect to the authorship and/or publication of this article.
Downloaded from adr.sagepub.com by guest on November 13, 2015 For personal use only. No other uses without permission. © International & American Associations for Dental Research
