Physiology & Behavior 136 (2014) 1–2
Contents lists available at ScienceDirect
Physiology & Behavior journal homepage: www.elsevier.com/locate/phb
Editorial
Introduction to the 2013 SSIB Special Issue
It is our pleasure as Guest Editors to introduce this special issue of Physiology and Behavior, which is based on selected presentations at the 2013 Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB) held in New Orleans, Louisiana, July 30th to August 3rd, 2013. We begin by acknowledging those who made the meeting possible, in particular Linda Rinaman of the University of Pittsburgh, who was SSIB's 2012–2013 president, and Matt Hayes of the University of Pennsylvania, who was program chair. I think we can all agree that Matt, along with Track-I chair Mitch Roitman from the University of Illinois and Track-II chair, Tanja Kral from the University of Pennsylvania, put together an absolutely terrific program, which can be seen reflected in this special issue. Finally, we acknowledge SPLTrak, who performs the Society's administration, provides technical support for the meeting, for all their very able help. We thank each of them sincerely in the name of SSIB. The special issue includes 24 manuscripts, of which 15 are reviews and 9 present original research. We open the special issue with two of three articles based on the Society's annual awards. First is “A physiological perspective on the neuroscience of eating”, written by one of us, Nori Geary of Weill Medical College of Cornell University, upon the occasion of being awarded the 2013 SSIB Distinguished Career Award for contributions to the study of endocrine controls of eating, in particular the control of meal size by pancreatic glucagon and, in females, by estrogens. Nori's essay begins by presenting the thesis that the neuroscience of eating should emphasize the study of eating under conditions that do not perturb, or minimally perturb, the organism's endogenous processes. This is followed by a perspective on today's cutting edge in the molecular neuroscience of eating and finally with a discussion of novel approaches that will advance eating neuroscience in the future. The second article is, “From fat fruitfly to human obesity,” by Wanli Smith, J Thomas, J Liu, T Li, all from the University of Maryland School of Pharmacy, and Timothy H. Moran, from the Johns Hopkins University School of Medicine. This article does “double duty.” Wanli was invited to write based on her presentation in the symposium Invertebrate Models in Feeding. Tim, as collaborator and co-author, felt the article nicely exemplifies the originality that led to his being awarded the Society's 2013 Hoebel Prize for Creativity. Their review critically appraises the advantages, and some limitations, of using the fruit fly (Drosophila melanogaster) for molecular-genetic investigations of obesity. As they point out, many genes related to mammalian energy homeostasis have fly homologues, and alterations in their expression mimics features of human metabolic disease. Furthermore, feeding fruit flies high-fat or high-sugar diets produces some effects similar to dietary obesity in rats, mice and humans. In addition, methods such as the capillary-feeder assay permit measurement of food intake and spontaneous feeding patterns in individual flies. Amongst the collection of articles in the 2013 Special Issue are six from the 10 2013 New Investigator Travel Awardees (NITAs). Daniel
http://dx.doi.org/10.1016/j.physbeh.2014.08.001 0031-9384/© 2014 Elsevier Inc. All rights reserved.
Castro, mentored by Kent Berridge at the University of Michigan, contributes a paper entitled “Advances in the neurobiological bases for food ‘liking’ versus ‘wanting’” with Kent Berridge. Annette de Kloet, mentored by Colin Sumners at the University of Florida School of Medicine, contributes a paper entitled “Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei” (with DJ Pioquinto, D Nguyen, L Wang, JA Smith, and H Hiller). Elizabeth Mietlicki-Baase, mentored by Matt Hayes at the University of Pennsylvania, contributes a paper entitled “Amylin activates distributed CNS nuclei to control energy balance” with Matt Hayes. Allison Kreisler, mentored by Linda Rinaman at the University of Pittsburgh, contributes a paper entitled “Differential activation of chemically identified neurons in the caudal nucleus of the solitary tract in non-entrained rats after intake of satiating vs. nonsatiating meals” (with E Davis). Adele Romano, mentored by Silvana Gaetani at the Sapienza University of Rome, contributes a paper entitled “High dietary fat intake influences the activation of specific hindbrain and hypothalamic nuclei by the satiety factor oleoylethanolamide” (with E Karimian Azari, B Tempesta, A Mansouri, MV Micioni di Bonaventura, D Ramachandran, TA Lutz, G Bedse, and W Langhans). Finally Xue Sun, mentored by Dana Small at Yale University, contributes a paper entitled “The neural signature of satiation is associated with ghrelin response and triglyceride metabolism” (with MG Veldhuizen, AE Wray, IE de Araujo, RS Sherman and R Sinha). We also congratulate Xue on being awarded the Gerard P Smith Award for the best presentation by a graduate student. Each year the program also includes the Presidential Symposium, this year highlighting SSIB: The Next Generation. Four of these promising young investigators are included in the special issue. Megan Dailey, then of Johns Hopkins University and now University of Illinois at UrbanaChampaign, contributes a paper entitled “Nutrient-induced intestinal adaptation and its effect in obesity” (with EC Gelfand and TH Moran). Bart De Jonghe from the University of Pennsylvania contributes a paper entitled “Cisplatin induces neuronal activation and increases central AMPA and NMDA receptor subunit gene expression in mice” (with RA Holland, JJ Leonard, NA Kensey, and PA Hannikainen). Pleunie Hogenkamp from Uppsala University contributes a paper entitled “The effect of sensory-nutrient congruency on food intake after repeated exposure: do texture and/or energy density matter?” Eric Krause from the University of Florida contributes a paper entitled “Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic–pituitary–adrenal axis in male mice” (with JA Smith, L Wang, H Hiller, CT Taylor, and A de Kloet). The next set of contributions to the 2012 Special Issue arises from other symposium presentations. These Symposia are planned by the Program Committee on the basis of suggestions from the membership and include both SSIB members and invited guests. Thus, Symposia
2
Editorial
both reflect and inform our scientific efforts. The Symposium speakers who contributed articles to the special issue are: from the Symposium Behavioral Economics and Food Reinforcement, Jennifer Temple (“Factors that influence the reinforcing value of foods and beverages”), Neil Rowland (“Energetics of food choice in mice: energy yield of the reinforcer,” with AM Giddings and V Minervini), and Collin Payne (“Shopper marketing nutrition interventions,” with M Niculescu, DR Just and M Kelly); from Appetite and Reward, Graham Finlayson (“Psychobiological examination of liking and wanting for fat and sweet taste in binge eating females,” with M Dalton), Kyle Burger (“A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior” with LA Berner), and Karolina Skibicka (“Dopamine signaling in the amygdala, increased by food ingestion and GLP-1, regulates feeding behavior” with RH Anderberg, C Anefors, F Bergquist, and H Nissbrandt); from Plasticity of the Gut-to-Brain Axis, Nicholas DiPatrizio (“Is fat taste ready for prime time?”), Guillaume De Lartigue (“Putative role of neuropeptides in vagal afferent signaling”), Amanda Page (“Plasticity of gastro-intestinal vagal afferent endings,” with S Kentish), and James Peters (“Channeling satiation: a primer on the role of TRP channels on the release of glutamate from vagal afferent neurons,” with S Wu and AJ Fenwick), and from Diet, Obesity and Cognition, Ashley Martin (“Human cognitive function and the obesogenic environment” with TL Davidson). The special issue closes with a manuscript by Diana Williams, from Florida State University, who was awarded the 2013 Alan N. Epstein Research Award for her innovative work on the neural and hormonal control of eating. Her manuscript is entitled, “Neural integration of satiation and food reward: Role of GLP-1 and orexin pathways.” In it, she thoughtfully reviews the central neural integration of what were formerly thought to be two separate functional systems, gastrointestinal satiation signaling and orosensory hedonic signaling. She first focuses on work, much of it from her laboratory, implicating projections of glucagon-like peptide-1 neurons from the nucleus of the solitary tract to the nucleus accumbens and ventral tegmental area as a mechanism through which meal-related signals may influence palatability and the motivation to obtain food. She next discusses how orexinergic projections from lateral hypothalamus to the nucleus of the solitary tract and area postrema may relay information related to the availability of rewarding food that leads to increases in the motivation to obtain food and reductions in satiation. She ends with the conclusion that the
brain mechanisms mediating hedonics, adipose-tissue-mass regulation and the controls of meal size and timing are extensively intermingled. This well informed and closely reasoned article is a pleasure to read. Finally, we note that SSIB's many initiatives and its professional meeting venue and services are far from inexpensive, and the 2013 Annual Meeting would not have been possible without the generous support we enjoyed from the corporations listed in Table 1. We gratefully acknowledge the contribution from each of these organizations. Table 1 Corporate benefactors Mars, Inc Corporate sponsors Ajinomoto North America, Inc. PepsiCo The Coca-Cola Company GlaxoSmithKline Consumer Healthcare Research Diets, Inc. Corporate Donors Advanced Targeting Systems Elsevier Lafayette–Cambden Neuroscience Sabel Systems International Senomyx TSE Systems
Dana M. Small Guest Editor Department of Psychiatry, Yale Medical School The John B Pierce Laboratory, University of Cologne, United States E-mail address: [email protected] Nori Geary Guest Editor Weill Cornell Medical College of Cornell University E-mail address: [email protected]
Contents lists available at ScienceDirect
Physiology & Behavior journal homepage: www.elsevier.com/locate/phb
Editorial
Introduction to the 2013 SSIB Special Issue
It is our pleasure as Guest Editors to introduce this special issue of Physiology and Behavior, which is based on selected presentations at the 2013 Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB) held in New Orleans, Louisiana, July 30th to August 3rd, 2013. We begin by acknowledging those who made the meeting possible, in particular Linda Rinaman of the University of Pittsburgh, who was SSIB's 2012–2013 president, and Matt Hayes of the University of Pennsylvania, who was program chair. I think we can all agree that Matt, along with Track-I chair Mitch Roitman from the University of Illinois and Track-II chair, Tanja Kral from the University of Pennsylvania, put together an absolutely terrific program, which can be seen reflected in this special issue. Finally, we acknowledge SPLTrak, who performs the Society's administration, provides technical support for the meeting, for all their very able help. We thank each of them sincerely in the name of SSIB. The special issue includes 24 manuscripts, of which 15 are reviews and 9 present original research. We open the special issue with two of three articles based on the Society's annual awards. First is “A physiological perspective on the neuroscience of eating”, written by one of us, Nori Geary of Weill Medical College of Cornell University, upon the occasion of being awarded the 2013 SSIB Distinguished Career Award for contributions to the study of endocrine controls of eating, in particular the control of meal size by pancreatic glucagon and, in females, by estrogens. Nori's essay begins by presenting the thesis that the neuroscience of eating should emphasize the study of eating under conditions that do not perturb, or minimally perturb, the organism's endogenous processes. This is followed by a perspective on today's cutting edge in the molecular neuroscience of eating and finally with a discussion of novel approaches that will advance eating neuroscience in the future. The second article is, “From fat fruitfly to human obesity,” by Wanli Smith, J Thomas, J Liu, T Li, all from the University of Maryland School of Pharmacy, and Timothy H. Moran, from the Johns Hopkins University School of Medicine. This article does “double duty.” Wanli was invited to write based on her presentation in the symposium Invertebrate Models in Feeding. Tim, as collaborator and co-author, felt the article nicely exemplifies the originality that led to his being awarded the Society's 2013 Hoebel Prize for Creativity. Their review critically appraises the advantages, and some limitations, of using the fruit fly (Drosophila melanogaster) for molecular-genetic investigations of obesity. As they point out, many genes related to mammalian energy homeostasis have fly homologues, and alterations in their expression mimics features of human metabolic disease. Furthermore, feeding fruit flies high-fat or high-sugar diets produces some effects similar to dietary obesity in rats, mice and humans. In addition, methods such as the capillary-feeder assay permit measurement of food intake and spontaneous feeding patterns in individual flies. Amongst the collection of articles in the 2013 Special Issue are six from the 10 2013 New Investigator Travel Awardees (NITAs). Daniel
http://dx.doi.org/10.1016/j.physbeh.2014.08.001 0031-9384/© 2014 Elsevier Inc. All rights reserved.
Castro, mentored by Kent Berridge at the University of Michigan, contributes a paper entitled “Advances in the neurobiological bases for food ‘liking’ versus ‘wanting’” with Kent Berridge. Annette de Kloet, mentored by Colin Sumners at the University of Florida School of Medicine, contributes a paper entitled “Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei” (with DJ Pioquinto, D Nguyen, L Wang, JA Smith, and H Hiller). Elizabeth Mietlicki-Baase, mentored by Matt Hayes at the University of Pennsylvania, contributes a paper entitled “Amylin activates distributed CNS nuclei to control energy balance” with Matt Hayes. Allison Kreisler, mentored by Linda Rinaman at the University of Pittsburgh, contributes a paper entitled “Differential activation of chemically identified neurons in the caudal nucleus of the solitary tract in non-entrained rats after intake of satiating vs. nonsatiating meals” (with E Davis). Adele Romano, mentored by Silvana Gaetani at the Sapienza University of Rome, contributes a paper entitled “High dietary fat intake influences the activation of specific hindbrain and hypothalamic nuclei by the satiety factor oleoylethanolamide” (with E Karimian Azari, B Tempesta, A Mansouri, MV Micioni di Bonaventura, D Ramachandran, TA Lutz, G Bedse, and W Langhans). Finally Xue Sun, mentored by Dana Small at Yale University, contributes a paper entitled “The neural signature of satiation is associated with ghrelin response and triglyceride metabolism” (with MG Veldhuizen, AE Wray, IE de Araujo, RS Sherman and R Sinha). We also congratulate Xue on being awarded the Gerard P Smith Award for the best presentation by a graduate student. Each year the program also includes the Presidential Symposium, this year highlighting SSIB: The Next Generation. Four of these promising young investigators are included in the special issue. Megan Dailey, then of Johns Hopkins University and now University of Illinois at UrbanaChampaign, contributes a paper entitled “Nutrient-induced intestinal adaptation and its effect in obesity” (with EC Gelfand and TH Moran). Bart De Jonghe from the University of Pennsylvania contributes a paper entitled “Cisplatin induces neuronal activation and increases central AMPA and NMDA receptor subunit gene expression in mice” (with RA Holland, JJ Leonard, NA Kensey, and PA Hannikainen). Pleunie Hogenkamp from Uppsala University contributes a paper entitled “The effect of sensory-nutrient congruency on food intake after repeated exposure: do texture and/or energy density matter?” Eric Krause from the University of Florida contributes a paper entitled “Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic–pituitary–adrenal axis in male mice” (with JA Smith, L Wang, H Hiller, CT Taylor, and A de Kloet). The next set of contributions to the 2012 Special Issue arises from other symposium presentations. These Symposia are planned by the Program Committee on the basis of suggestions from the membership and include both SSIB members and invited guests. Thus, Symposia
2
Editorial
both reflect and inform our scientific efforts. The Symposium speakers who contributed articles to the special issue are: from the Symposium Behavioral Economics and Food Reinforcement, Jennifer Temple (“Factors that influence the reinforcing value of foods and beverages”), Neil Rowland (“Energetics of food choice in mice: energy yield of the reinforcer,” with AM Giddings and V Minervini), and Collin Payne (“Shopper marketing nutrition interventions,” with M Niculescu, DR Just and M Kelly); from Appetite and Reward, Graham Finlayson (“Psychobiological examination of liking and wanting for fat and sweet taste in binge eating females,” with M Dalton), Kyle Burger (“A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior” with LA Berner), and Karolina Skibicka (“Dopamine signaling in the amygdala, increased by food ingestion and GLP-1, regulates feeding behavior” with RH Anderberg, C Anefors, F Bergquist, and H Nissbrandt); from Plasticity of the Gut-to-Brain Axis, Nicholas DiPatrizio (“Is fat taste ready for prime time?”), Guillaume De Lartigue (“Putative role of neuropeptides in vagal afferent signaling”), Amanda Page (“Plasticity of gastro-intestinal vagal afferent endings,” with S Kentish), and James Peters (“Channeling satiation: a primer on the role of TRP channels on the release of glutamate from vagal afferent neurons,” with S Wu and AJ Fenwick), and from Diet, Obesity and Cognition, Ashley Martin (“Human cognitive function and the obesogenic environment” with TL Davidson). The special issue closes with a manuscript by Diana Williams, from Florida State University, who was awarded the 2013 Alan N. Epstein Research Award for her innovative work on the neural and hormonal control of eating. Her manuscript is entitled, “Neural integration of satiation and food reward: Role of GLP-1 and orexin pathways.” In it, she thoughtfully reviews the central neural integration of what were formerly thought to be two separate functional systems, gastrointestinal satiation signaling and orosensory hedonic signaling. She first focuses on work, much of it from her laboratory, implicating projections of glucagon-like peptide-1 neurons from the nucleus of the solitary tract to the nucleus accumbens and ventral tegmental area as a mechanism through which meal-related signals may influence palatability and the motivation to obtain food. She next discusses how orexinergic projections from lateral hypothalamus to the nucleus of the solitary tract and area postrema may relay information related to the availability of rewarding food that leads to increases in the motivation to obtain food and reductions in satiation. She ends with the conclusion that the
brain mechanisms mediating hedonics, adipose-tissue-mass regulation and the controls of meal size and timing are extensively intermingled. This well informed and closely reasoned article is a pleasure to read. Finally, we note that SSIB's many initiatives and its professional meeting venue and services are far from inexpensive, and the 2013 Annual Meeting would not have been possible without the generous support we enjoyed from the corporations listed in Table 1. We gratefully acknowledge the contribution from each of these organizations. Table 1 Corporate benefactors Mars, Inc Corporate sponsors Ajinomoto North America, Inc. PepsiCo The Coca-Cola Company GlaxoSmithKline Consumer Healthcare Research Diets, Inc. Corporate Donors Advanced Targeting Systems Elsevier Lafayette–Cambden Neuroscience Sabel Systems International Senomyx TSE Systems
Dana M. Small Guest Editor Department of Psychiatry, Yale Medical School The John B Pierce Laboratory, University of Cologne, United States E-mail address: [email protected] Nori Geary Guest Editor Weill Cornell Medical College of Cornell University E-mail address: [email protected]
