CB33_FrontMatter
ARI
20 September 2017
7:44
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
Introduction: The Challenge to Science in the Arena of Public Policy Last year in this space, I wrote about the challenge of experimental reproducibility, with an emphasis on the biomedical sciences. This year, I wish to extend this to the broader concern of misrepresentation of science for political purposes. Science progresses by the slow and steady accumulation of observation, theory, and experiment. Facts are established only after extensive and sometimes critical evaluation, with opposing sides contesting alternative results and interpretations. The British philosopher of science Karl Popper argued that the strength of a scientific theory rested on it being subject to the test of falsifiability, the application of criticism to the basis of the theory. A theory not subject to the test of criticism is not a scientific theory. Science, then, is distinct from other forms of human endeavor such as art, literature, and beliefs. The scientific method is a quest to refute or to falsify the theory, and thus the advance of scientific knowledge rests on a continuing challenge to prevailing theories of the natural world. Our knowledge of the age of the Earth and the universe and the theory of biological evolution are solid products of the scientific method having been established over decades, indeed centuries, of investigation. And yet, the scientific method holds that these principles must remain subject to skeptical inquiry and refinement. But the challenges must themselves be based on scientific reasoning, and not the dogma of skeptics who would rely on myths from thousands of years ago that are not themselves subject to the scientific method. Such skeptics come and go, but the fruit of human knowledge will remain and advance. In the United States, we face a new skepticism, grounded in the politics of energy and commerce, challenging the consensus scientific view that our climate is influenced by human activity. We must welcome skepticism, but again, the challenge must be on the basis of experiment, observation, and theory, not blind dogma. We hear arguments that the jury is still out and that we must continue to observe, which of course are true. But the arguments ring hollow with regard to the application of our knowledge to public policy, and they remind us of the congressional testimony of the executives of the tobacco industry who in 1994 asserted that cigarettes may cause lung cancer, heart disease, and other health problems but that the evidence is not conclusive (http://www.nytimes.com/1994/04/15/us/tobacco-chiefs-say-cigarettes-aren-taddictive.html?pagewanted=all)—sound familiar?
https://doi.org/10.1146/annurev-cb-33-092017-100001 v
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20 September 2017
7:44
We face a determined opposition that would misrepresent the prevailing view of expert scientists and, worse yet, would attempt to expunge from government sources any mention of climate change and cut off funding for continuing to advance the science even while asserting that the science must continue. But how can it continue without funding or access to the store of knowledge already accumulated by government scientists? Fortunately, most of the rest of the world has embraced the lessons of climate science, and in the private sector, employment in renewable energy industries is accelerating at a pace far outstripping the fossil fuel industry. We may sustain a temporary setback in the United States, but the march of progress fueled by the scientific method will advance and ultimately tackle our greatest challenges. Although some researchers are in the direct firing line of these challenges, it is important that all of us hold ourselves to the highest standards. I am grateful to my colleagues on the Annual Review of Cell and Developmental Biology Editorial Committee for doing so and particularly to Shirley Park, our Production Editor, and to Larry Goldstein and Ruth Lehmann, who share responsibility for editorial oversight of this journal. We welcome, to the Committee, Erin Schuman and Hao Yu, who as of 2016 bring fresh perspectives in the areas of molecular control of the neuronal synapse and gene regulatory networks involved in the control of reproductive development and hormone signaling in plants, respectively. I am pleased that this year’s Perspective, a regular feature of this journal, has been contributed by J. Richard McIntosh, a pioneer of the mammalian microtubule cytoskeleton and a premier morphological and molecular cell biologist.
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
CB33_FrontMatter
Randy Schekman Berkeley, California
vi
Introduction
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
CB33_FrontMatter
ARI
20 September 2017
7:44
Figure 1 Annual Review of Cell and Developmental Biology editorial committee. (Back row) Erin Schuman, Alexander Schier, Jennifer LippincottSchwartz, and Tony Hunter. (Front row) Philippa Marrack, Ruth Lehmann, Randy Schekman, and Larry Goldstein.
ANNUAL REVIEWS Connect With Our Experts
New From Annual Reviews:
ONLINE NOW!
Annual Review of Cancer Biology
cancerbio.annualreviews.org • Volume 1 • March 2017
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
Co-Editors: Tyler Jacks, Massachusetts Institute of Technology Charles L. Sawyers, Memorial Sloan Kettering Cancer Center The Annual Review of Cancer Biology reviews a range of subjects representing important and emerging areas in the field of cancer research. The Annual Review of Cancer Biology includes three broad themes: Cancer Cell Biology, Tumorigenesis and Cancer Progression, and Translational Cancer Science.
TABLE OF CONTENTS FOR VOLUME 1:
• How Tumor Virology Evolved into Cancer Biology and Transformed Oncology, Harold Varmus • The Role of Autophagy in Cancer, Naiara Santana-Codina, Joseph D. Mancias, Alec C. Kimmelman • Cell Cycle–Targeted Cancer Therapies, Charles J. Sherr, Jiri Bartek • Ubiquitin in Cell-Cycle Regulation and Dysregulation in Cancer, Natalie A. Borg, Vishva M. Dixit • The Two Faces of Reactive Oxygen Species in Cancer, Colleen R. Reczek, Navdeep S. Chandel • Analyzing Tumor Metabolism In Vivo, Brandon Faubert, Ralph J. DeBerardinis • Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance, Devon M. Fitzgerald, P.J. Hastings, Susan M. Rosenberg • Synthetic Lethality in Cancer Therapeutics, Roderick L. Beijersbergen, Lodewyk F.A. Wessels, René Bernards • Noncoding RNAs in Cancer Development, Chao-Po Lin, Lin He • p53: Multiple Facets of a Rubik’s Cube, Yun Zhang, Guillermina Lozano • Resisting Resistance, Ivana Bozic, Martin A. Nowak • Deciphering Genetic Intratumor Heterogeneity and Its Impact on Cancer Evolution, Rachel Rosenthal, Nicholas McGranahan, Javier Herrero, Charles Swanton
• Immune-Suppressing Cellular Elements of the Tumor Microenvironment, Douglas T. Fearon • Overcoming On-Target Resistance to Tyrosine Kinase Inhibitors in Lung Cancer, Ibiayi Dagogo-Jack, Jeffrey A. Engelman, Alice T. Shaw • Apoptosis and Cancer, Anthony Letai • Chemical Carcinogenesis Models of Cancer: Back to the Future, Melissa Q. McCreery, Allan Balmain • Extracellular Matrix Remodeling and Stiffening Modulate Tumor Phenotype and Treatment Response, Jennifer L. Leight, Allison P. Drain, Valerie M. Weaver • Aneuploidy in Cancer: Seq-ing Answers to Old Questions, Kristin A. Knouse, Teresa Davoli, Stephen J. Elledge, Angelika Amon • The Role of Chromatin-Associated Proteins in Cancer, Kristian Helin, Saverio Minucci • Targeted Differentiation Therapy with Mutant IDH Inhibitors: Early Experiences and Parallels with Other Differentiation Agents, Eytan Stein, Katharine Yen • Determinants of Organotropic Metastasis, Heath A. Smith, Yibin Kang • Multiple Roles for the MLL/COMPASS Family in the Epigenetic Regulation of Gene Expression and in Cancer, Joshua J. Meeks, Ali Shilatifard • Chimeric Antigen Receptors: A Paradigm Shift in Immunotherapy, Michel Sadelain
ANNUAL REVIEWS | CONNECT WITH OUR EXPERTS 650.493.4400/800.523.8635 (us/can) www.annualreviews.org | [email protected]
CB33_FrontMatter
ARI
9 September 2017
11:34
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
Contents
Annual Review of Cell and Developmental Biology Volume 33, 2017
Assessing the Contributions of Motor Enzymes and Microtubule Dynamics to Mitotic Chromosome Motions J. Richard McIntosh p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 1 Centriole Biogenesis: From Identifying the Characters to Understanding the Plot Niccol`o Banterle and Pierre G¨onczy p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p23 Microtubule-Organizing Centers Jingchao Wu and Anna Akhmanova p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p51 Cell Polarity in Yeast Jian-geng Chiou, Mohan K. Balasubramanian, and Daniel J. Lew p p p p p p p p p p p p p p p p p p p p p p p77 Excitable Signal Transduction Networks in Directed Cell Migration Peter N. Devreotes, Sayak Bhattacharya, Marc Edwards, Pablo A. Iglesias, Thomas Lampert, and Yuchuan Miao p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 103 Cell Removal: Efferocytosis Peter M. Henson p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 127 Sending and Receiving Hedgehog Signals Kostadin Petrov, Bradley M. Wierbowski, and Adrian Salic p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 145 Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System Daniel P. Kiehart, Janice M. Crawford, Andreas Aristotelous, Stephanos Venakides, and Glenn S. Edwards p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 169 Lessons from Interspecies Mammalian Chimeras Fabian Suchy and Hiromitsu Nakauchi p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 203 Temporal Patterning in the Drosophila CNS Chris Q. Doe p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 219
vii
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Unconventional Roles of Opsins Nicole Y. Leung and Craig Montell p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 241 The Three-Dimensional Organization of Mammalian Genomes Miao Yu and Bing Ren p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 265 The Inherent Asymmetry of DNA Replication Jonathan Snedeker, Matthew Wooten, and Xin Chen p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 291 Rethinking m6 A Readers, Writers, and Erasers Kate D. Meyer and Samie R. Jaffrey p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 319
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
Ribosomal Stalling During Translation: Providing Substrates for Ribosome-Associated Protein Quality Control Claudio A.P. Joazeiro p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 343 Structural and Mechanistic Insights into Protein Translocation Tom A. Rapoport, Long Li, and Eunyong Park p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 369 In Search of Lost Small Peptides Serge Plaza, Gerben Menschaert, and Fran¸cois Payre p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 391 Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion Un Seng Chio, Hyunju Cho, and Shu-ou Shan p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 417 Coping with Protein Quality Control Failure Esther Pilla, Kim Schneider, and Anne Bertolotti p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 439 Proteostatic Tactics in the Strategy of Sterol Regulation Margaret A. Wangeline, Nidhi Vashistha, and Randolph Y. Hampton p p p p p p p p p p p p p p p p p 467 Lipid Droplet Biogenesis Tobias C. Walther, Jeeyun Chung, and Robert V. Farese Jr. p p p p p p p p p p p p p p p p p p p p p p p p p p p p 491 Unconventional or Preset αβ T Cells: Evolutionarily Conserved Tissue-Resident T Cells Recognizing Nonpeptidic Ligands Francois Legoux, Marion Salou, and Olivier Lantz p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 511 How Single-Cell Genomics Is Changing Evolutionary and Developmental Biology John C. Marioni and Detlev Arendt p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 537 The FLC Locus: A Platform for Discoveries in Epigenetics and Adaptation Charles Whittaker and Caroline Dean p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 555 Sex and Gender Differences in the Outcomes of Vaccination over the Life Course Katie L. Flanagan, Ashley L. Fink, Magdalena Plebanski, and Sabra L. Klein p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 577
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Contents
ARI
20 September 2017
7:44
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
Introduction: The Challenge to Science in the Arena of Public Policy Last year in this space, I wrote about the challenge of experimental reproducibility, with an emphasis on the biomedical sciences. This year, I wish to extend this to the broader concern of misrepresentation of science for political purposes. Science progresses by the slow and steady accumulation of observation, theory, and experiment. Facts are established only after extensive and sometimes critical evaluation, with opposing sides contesting alternative results and interpretations. The British philosopher of science Karl Popper argued that the strength of a scientific theory rested on it being subject to the test of falsifiability, the application of criticism to the basis of the theory. A theory not subject to the test of criticism is not a scientific theory. Science, then, is distinct from other forms of human endeavor such as art, literature, and beliefs. The scientific method is a quest to refute or to falsify the theory, and thus the advance of scientific knowledge rests on a continuing challenge to prevailing theories of the natural world. Our knowledge of the age of the Earth and the universe and the theory of biological evolution are solid products of the scientific method having been established over decades, indeed centuries, of investigation. And yet, the scientific method holds that these principles must remain subject to skeptical inquiry and refinement. But the challenges must themselves be based on scientific reasoning, and not the dogma of skeptics who would rely on myths from thousands of years ago that are not themselves subject to the scientific method. Such skeptics come and go, but the fruit of human knowledge will remain and advance. In the United States, we face a new skepticism, grounded in the politics of energy and commerce, challenging the consensus scientific view that our climate is influenced by human activity. We must welcome skepticism, but again, the challenge must be on the basis of experiment, observation, and theory, not blind dogma. We hear arguments that the jury is still out and that we must continue to observe, which of course are true. But the arguments ring hollow with regard to the application of our knowledge to public policy, and they remind us of the congressional testimony of the executives of the tobacco industry who in 1994 asserted that cigarettes may cause lung cancer, heart disease, and other health problems but that the evidence is not conclusive (http://www.nytimes.com/1994/04/15/us/tobacco-chiefs-say-cigarettes-aren-taddictive.html?pagewanted=all)—sound familiar?
https://doi.org/10.1146/annurev-cb-33-092017-100001 v
ARI
20 September 2017
7:44
We face a determined opposition that would misrepresent the prevailing view of expert scientists and, worse yet, would attempt to expunge from government sources any mention of climate change and cut off funding for continuing to advance the science even while asserting that the science must continue. But how can it continue without funding or access to the store of knowledge already accumulated by government scientists? Fortunately, most of the rest of the world has embraced the lessons of climate science, and in the private sector, employment in renewable energy industries is accelerating at a pace far outstripping the fossil fuel industry. We may sustain a temporary setback in the United States, but the march of progress fueled by the scientific method will advance and ultimately tackle our greatest challenges. Although some researchers are in the direct firing line of these challenges, it is important that all of us hold ourselves to the highest standards. I am grateful to my colleagues on the Annual Review of Cell and Developmental Biology Editorial Committee for doing so and particularly to Shirley Park, our Production Editor, and to Larry Goldstein and Ruth Lehmann, who share responsibility for editorial oversight of this journal. We welcome, to the Committee, Erin Schuman and Hao Yu, who as of 2016 bring fresh perspectives in the areas of molecular control of the neuronal synapse and gene regulatory networks involved in the control of reproductive development and hormone signaling in plants, respectively. I am pleased that this year’s Perspective, a regular feature of this journal, has been contributed by J. Richard McIntosh, a pioneer of the mammalian microtubule cytoskeleton and a premier morphological and molecular cell biologist.
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
CB33_FrontMatter
Randy Schekman Berkeley, California
vi
Introduction
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
CB33_FrontMatter
ARI
20 September 2017
7:44
Figure 1 Annual Review of Cell and Developmental Biology editorial committee. (Back row) Erin Schuman, Alexander Schier, Jennifer LippincottSchwartz, and Tony Hunter. (Front row) Philippa Marrack, Ruth Lehmann, Randy Schekman, and Larry Goldstein.
ANNUAL REVIEWS Connect With Our Experts
New From Annual Reviews:
ONLINE NOW!
Annual Review of Cancer Biology
cancerbio.annualreviews.org • Volume 1 • March 2017
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
Co-Editors: Tyler Jacks, Massachusetts Institute of Technology Charles L. Sawyers, Memorial Sloan Kettering Cancer Center The Annual Review of Cancer Biology reviews a range of subjects representing important and emerging areas in the field of cancer research. The Annual Review of Cancer Biology includes three broad themes: Cancer Cell Biology, Tumorigenesis and Cancer Progression, and Translational Cancer Science.
TABLE OF CONTENTS FOR VOLUME 1:
• How Tumor Virology Evolved into Cancer Biology and Transformed Oncology, Harold Varmus • The Role of Autophagy in Cancer, Naiara Santana-Codina, Joseph D. Mancias, Alec C. Kimmelman • Cell Cycle–Targeted Cancer Therapies, Charles J. Sherr, Jiri Bartek • Ubiquitin in Cell-Cycle Regulation and Dysregulation in Cancer, Natalie A. Borg, Vishva M. Dixit • The Two Faces of Reactive Oxygen Species in Cancer, Colleen R. Reczek, Navdeep S. Chandel • Analyzing Tumor Metabolism In Vivo, Brandon Faubert, Ralph J. DeBerardinis • Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance, Devon M. Fitzgerald, P.J. Hastings, Susan M. Rosenberg • Synthetic Lethality in Cancer Therapeutics, Roderick L. Beijersbergen, Lodewyk F.A. Wessels, René Bernards • Noncoding RNAs in Cancer Development, Chao-Po Lin, Lin He • p53: Multiple Facets of a Rubik’s Cube, Yun Zhang, Guillermina Lozano • Resisting Resistance, Ivana Bozic, Martin A. Nowak • Deciphering Genetic Intratumor Heterogeneity and Its Impact on Cancer Evolution, Rachel Rosenthal, Nicholas McGranahan, Javier Herrero, Charles Swanton
• Immune-Suppressing Cellular Elements of the Tumor Microenvironment, Douglas T. Fearon • Overcoming On-Target Resistance to Tyrosine Kinase Inhibitors in Lung Cancer, Ibiayi Dagogo-Jack, Jeffrey A. Engelman, Alice T. Shaw • Apoptosis and Cancer, Anthony Letai • Chemical Carcinogenesis Models of Cancer: Back to the Future, Melissa Q. McCreery, Allan Balmain • Extracellular Matrix Remodeling and Stiffening Modulate Tumor Phenotype and Treatment Response, Jennifer L. Leight, Allison P. Drain, Valerie M. Weaver • Aneuploidy in Cancer: Seq-ing Answers to Old Questions, Kristin A. Knouse, Teresa Davoli, Stephen J. Elledge, Angelika Amon • The Role of Chromatin-Associated Proteins in Cancer, Kristian Helin, Saverio Minucci • Targeted Differentiation Therapy with Mutant IDH Inhibitors: Early Experiences and Parallels with Other Differentiation Agents, Eytan Stein, Katharine Yen • Determinants of Organotropic Metastasis, Heath A. Smith, Yibin Kang • Multiple Roles for the MLL/COMPASS Family in the Epigenetic Regulation of Gene Expression and in Cancer, Joshua J. Meeks, Ali Shilatifard • Chimeric Antigen Receptors: A Paradigm Shift in Immunotherapy, Michel Sadelain
ANNUAL REVIEWS | CONNECT WITH OUR EXPERTS 650.493.4400/800.523.8635 (us/can) www.annualreviews.org | [email protected]
CB33_FrontMatter
ARI
9 September 2017
11:34
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
Contents
Annual Review of Cell and Developmental Biology Volume 33, 2017
Assessing the Contributions of Motor Enzymes and Microtubule Dynamics to Mitotic Chromosome Motions J. Richard McIntosh p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 1 Centriole Biogenesis: From Identifying the Characters to Understanding the Plot Niccol`o Banterle and Pierre G¨onczy p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p23 Microtubule-Organizing Centers Jingchao Wu and Anna Akhmanova p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p51 Cell Polarity in Yeast Jian-geng Chiou, Mohan K. Balasubramanian, and Daniel J. Lew p p p p p p p p p p p p p p p p p p p p p p p77 Excitable Signal Transduction Networks in Directed Cell Migration Peter N. Devreotes, Sayak Bhattacharya, Marc Edwards, Pablo A. Iglesias, Thomas Lampert, and Yuchuan Miao p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 103 Cell Removal: Efferocytosis Peter M. Henson p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 127 Sending and Receiving Hedgehog Signals Kostadin Petrov, Bradley M. Wierbowski, and Adrian Salic p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 145 Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System Daniel P. Kiehart, Janice M. Crawford, Andreas Aristotelous, Stephanos Venakides, and Glenn S. Edwards p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 169 Lessons from Interspecies Mammalian Chimeras Fabian Suchy and Hiromitsu Nakauchi p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 203 Temporal Patterning in the Drosophila CNS Chris Q. Doe p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 219
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Unconventional Roles of Opsins Nicole Y. Leung and Craig Montell p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 241 The Three-Dimensional Organization of Mammalian Genomes Miao Yu and Bing Ren p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 265 The Inherent Asymmetry of DNA Replication Jonathan Snedeker, Matthew Wooten, and Xin Chen p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 291 Rethinking m6 A Readers, Writers, and Erasers Kate D. Meyer and Samie R. Jaffrey p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 319
Annu. Rev. Cell Dev. Biol. 2017.33:v-vii. Downloaded from www.annualreviews.org Access provided by 80.82.77.83 on 10/18/17. For personal use only.
Ribosomal Stalling During Translation: Providing Substrates for Ribosome-Associated Protein Quality Control Claudio A.P. Joazeiro p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 343 Structural and Mechanistic Insights into Protein Translocation Tom A. Rapoport, Long Li, and Eunyong Park p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 369 In Search of Lost Small Peptides Serge Plaza, Gerben Menschaert, and Fran¸cois Payre p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 391 Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion Un Seng Chio, Hyunju Cho, and Shu-ou Shan p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 417 Coping with Protein Quality Control Failure Esther Pilla, Kim Schneider, and Anne Bertolotti p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 439 Proteostatic Tactics in the Strategy of Sterol Regulation Margaret A. Wangeline, Nidhi Vashistha, and Randolph Y. Hampton p p p p p p p p p p p p p p p p p 467 Lipid Droplet Biogenesis Tobias C. Walther, Jeeyun Chung, and Robert V. Farese Jr. p p p p p p p p p p p p p p p p p p p p p p p p p p p p 491 Unconventional or Preset αβ T Cells: Evolutionarily Conserved Tissue-Resident T Cells Recognizing Nonpeptidic Ligands Francois Legoux, Marion Salou, and Olivier Lantz p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 511 How Single-Cell Genomics Is Changing Evolutionary and Developmental Biology John C. Marioni and Detlev Arendt p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 537 The FLC Locus: A Platform for Discoveries in Epigenetics and Adaptation Charles Whittaker and Caroline Dean p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 555 Sex and Gender Differences in the Outcomes of Vaccination over the Life Course Katie L. Flanagan, Ashley L. Fink, Magdalena Plebanski, and Sabra L. Klein p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p 577
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