Acta Oto-Laryngologica
ISSN: 0001-6489 (Print) 1651-2251 (Online) Journal homepage: http://www.tandfonline.com/loi/ioto20
Intravenous Xylocaine in the Treatment of Attacks of Meniere's Disease T. Gejrot To cite this article: T. Gejrot (1976) Intravenous Xylocaine in the Treatment of Attacks of Meniere's Disease, Acta Oto-Laryngologica, 82:1-6, 301-302, DOI: 10.3109/00016487609120911 To link to this article: http://dx.doi.org/10.3109/00016487609120911
Published online: 08 Jul 2009.
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Date: 10 April 2016, At: 00:59
Acta Otolaryngol82: 301-302, 1976
INTRAVENOUS XYLOCAINE IN THE TREATMENT OF ATTACKS OF MENIERE’S DISEASE
T. Gejrot
Downloaded by [McMaster University] at 00:59 10 April 2016
From the Department of Otolaryngology, Lasarettet, Kristianstad, Sweden
Abstract. The effect of xylocaine on epileptic attacks suggested a study of its effect in attacks of Meniere’s disease, as the symptoms can be very much alike in the two conditions. The results were found to be excellent, especially as regards the vegetative dysfunctions. In attacks of Meniere’s disease the tinnitus disappeared for 20 minutes, vomiting generally disappeared for good and nausea for an hour or two. Nystagmus was unaffected.
Similar symptoms in attacks of Meniere’s disease and epileptic seizures without loss of consciousness have prompted the use of xylocaine in antiepileptic dosage in attacks of Meniere’s disease. A one per cent solution without epinephrine is used in a dose of 1 mg per kg body weight, administered intravenously at a rate of 6 mg per minute. It is given during attacks and in periods with severe nausea. The results of this antiepileptic therapy in attacks of Meniere’s disease have been strikingly good, especially as regards the vegetative reactions. In most cases, the nausea and vomiting disappear dramatically after about a minute, and the patient can move about freely. In other cases, the relief is so good that the patient can sit up and take a meal without complications. If the symptoms are continuous, xylocaine infusion may be used. Tinnitus usually disappears for about 20 20-762959
minutes, following which it gradually returns. In this antiepileptic dose, xylocaine has no sedative side effects and does not change the pure-tqne audiogram or nystagmus. As in seasickness, there are two forms of attacks of Meniere’s disease. Xylocaine is useful in the so-called agitatoric type with vomiting, nausea and anxiety. In the asthenic type with depression, nausea and decreased blood pressure, it has little or no effect. In 1963, the results obtained in eleven patients treated with xylocaine in attacks of Meniere’s disease were reported by Gejrot. Since then, hundreds of patients have been treated with a single or repeated doses of 1-3 mg per kg body weight. Contra-indications are bradycardia, serious types of conduction disturbances of the heart, and a known history of hypersensitivity to local anaesthetics of the amide type. There have been no complications, and the results have been excellent, particularly in the agitatoric type. In epileptic seizures xylocaine acts at the cortical level. The favourable effect of antiepileptic therapy on similar vegetative disturbances in agitatoric attacks of Meniere’s disease, seasickness and caloric stimulation suggests an epileptic equivalent. Actu Otoluiyngol82
302
T . Gejrot REFERENCES
Die Wirkung von intravenosen Dosen von Xylocain auf epileptische Attacke veranldte ein Studium der Wirkung in der Meniereschen Krankheit, da die Symptome sehr ahnlich sein konnen. Die Ergebnisse waren sehr gut, speziell betreffs der vegetativen Storungen. In den Attacken der Meniereschen Krankheit horte das Sausen wahrend 20 Minuten auf. Erbrechen verschwand im allgemeinen uberhaupt und die Ubelkeit wahrend einer Stunde oder zwei. Nystagmus wurde nicht beeinfluBt.
Bernhard, C. G. & Bohm, E. 1954. On the central effects of with special references to its influence on epileptic phenomena. Acta Physiol Scand, Suppl. 114, 5 . Gejrot, T. 1963. Intravenous xylocaine in the treatment of attacks of Meniere’s disease. Acta Otolaryngol (Stockh), Suppl. 188, 190. - 1963. The influence of xylocaine on induced and spontaneous nystagmus. Pract Otorhinolaryngol (Basel) 25, 36 1.
Downloaded by [McMaster University] at 00:59 10 April 2016
ZUSAMMENFASSUNG
Acta Otoluryngol82
ISSN: 0001-6489 (Print) 1651-2251 (Online) Journal homepage: http://www.tandfonline.com/loi/ioto20
Intravenous Xylocaine in the Treatment of Attacks of Meniere's Disease T. Gejrot To cite this article: T. Gejrot (1976) Intravenous Xylocaine in the Treatment of Attacks of Meniere's Disease, Acta Oto-Laryngologica, 82:1-6, 301-302, DOI: 10.3109/00016487609120911 To link to this article: http://dx.doi.org/10.3109/00016487609120911
Published online: 08 Jul 2009.
Submit your article to this journal
Article views: 6
View related articles
Citing articles: 4 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=ioto20 Download by: [McMaster University]
Date: 10 April 2016, At: 00:59
Acta Otolaryngol82: 301-302, 1976
INTRAVENOUS XYLOCAINE IN THE TREATMENT OF ATTACKS OF MENIERE’S DISEASE
T. Gejrot
Downloaded by [McMaster University] at 00:59 10 April 2016
From the Department of Otolaryngology, Lasarettet, Kristianstad, Sweden
Abstract. The effect of xylocaine on epileptic attacks suggested a study of its effect in attacks of Meniere’s disease, as the symptoms can be very much alike in the two conditions. The results were found to be excellent, especially as regards the vegetative dysfunctions. In attacks of Meniere’s disease the tinnitus disappeared for 20 minutes, vomiting generally disappeared for good and nausea for an hour or two. Nystagmus was unaffected.
Similar symptoms in attacks of Meniere’s disease and epileptic seizures without loss of consciousness have prompted the use of xylocaine in antiepileptic dosage in attacks of Meniere’s disease. A one per cent solution without epinephrine is used in a dose of 1 mg per kg body weight, administered intravenously at a rate of 6 mg per minute. It is given during attacks and in periods with severe nausea. The results of this antiepileptic therapy in attacks of Meniere’s disease have been strikingly good, especially as regards the vegetative reactions. In most cases, the nausea and vomiting disappear dramatically after about a minute, and the patient can move about freely. In other cases, the relief is so good that the patient can sit up and take a meal without complications. If the symptoms are continuous, xylocaine infusion may be used. Tinnitus usually disappears for about 20 20-762959
minutes, following which it gradually returns. In this antiepileptic dose, xylocaine has no sedative side effects and does not change the pure-tqne audiogram or nystagmus. As in seasickness, there are two forms of attacks of Meniere’s disease. Xylocaine is useful in the so-called agitatoric type with vomiting, nausea and anxiety. In the asthenic type with depression, nausea and decreased blood pressure, it has little or no effect. In 1963, the results obtained in eleven patients treated with xylocaine in attacks of Meniere’s disease were reported by Gejrot. Since then, hundreds of patients have been treated with a single or repeated doses of 1-3 mg per kg body weight. Contra-indications are bradycardia, serious types of conduction disturbances of the heart, and a known history of hypersensitivity to local anaesthetics of the amide type. There have been no complications, and the results have been excellent, particularly in the agitatoric type. In epileptic seizures xylocaine acts at the cortical level. The favourable effect of antiepileptic therapy on similar vegetative disturbances in agitatoric attacks of Meniere’s disease, seasickness and caloric stimulation suggests an epileptic equivalent. Actu Otoluiyngol82
302
T . Gejrot REFERENCES
Die Wirkung von intravenosen Dosen von Xylocain auf epileptische Attacke veranldte ein Studium der Wirkung in der Meniereschen Krankheit, da die Symptome sehr ahnlich sein konnen. Die Ergebnisse waren sehr gut, speziell betreffs der vegetativen Storungen. In den Attacken der Meniereschen Krankheit horte das Sausen wahrend 20 Minuten auf. Erbrechen verschwand im allgemeinen uberhaupt und die Ubelkeit wahrend einer Stunde oder zwei. Nystagmus wurde nicht beeinfluBt.
Bernhard, C. G. & Bohm, E. 1954. On the central effects of with special references to its influence on epileptic phenomena. Acta Physiol Scand, Suppl. 114, 5 . Gejrot, T. 1963. Intravenous xylocaine in the treatment of attacks of Meniere’s disease. Acta Otolaryngol (Stockh), Suppl. 188, 190. - 1963. The influence of xylocaine on induced and spontaneous nystagmus. Pract Otorhinolaryngol (Basel) 25, 36 1.
Downloaded by [McMaster University] at 00:59 10 April 2016
ZUSAMMENFASSUNG
Acta Otoluryngol82
