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Anesthesia: Essays and Researches

Original Article

Intrathecal nalbuphine as an adjuvant to subarachnoid block: What is the most effective dose? Arghya Mukherjee, Anirban Pal1, Jitendra Agrawal, Amrita Mehrotra, Nidhi Dawar2 Department of Anesthesiology, GR Medical College, Gwalior, Madhya Pradesh, 1Department of Anesthesiology, Calcutta National Medical College (CNMC), Kolkata, West Bengal, 2Specialist Medical Officer (Anaesthesiology), West Bengal Health Service, West Bengal, India Corresponding author: Dr. Anirban Pal, 43/6/5 Jheel Road, Kolkata - 700 031, West Bengal, India. E-mail: [email protected]

Abstract Background: Nalbuphine has been used intrathecally as an adjuvant in previous studies, but none clearly state the most effective dose of nalbuphine. The purpose of our study was to establish the effectiveness of intrathecal nalbuphine as an adjuvant, compare three different doses and determine the optimum dose with prolonged analgesic effect and minimal side-effects. Materials and Methods: In this prospective, randomized, double-blinded, controlled study, 100 ASA I and II patients undergoing lower limb orthopedic surgery under subarachnoid block (SAB), were randomly allocated to four groups: A, B, C and D, to receive 0.5 ml normal saline (NS) or 0.2, 0.4 and 0.8 mg nalbuphine made up to 0.5 ml with NS added to 0.5% hyperbaric bupivacaine 12.5 mg (total volume 3 ml), respectively. The onset of sensory and motor blockade, two-segment regression time of sensory blockade, duration of motor blockade and analgesia, visual analogue scale (VAS) pain score and side-effects were compared between the groups. Results: Two-segment regression time of sensory blockade and duration of effective analgesia was prolonged in groups C (0.4 mg nalbuphine) and D (0.8 mg nalbuphine) (P

Intrathecal nalbuphine as an adjuvant to subarachnoid block: What is the most effective dose?

Nalbuphine has been used intrathecally as an adjuvant in previous studies, but none clearly state the most effective dose of nalbuphine. The purpose o...
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