RESEARCH ARTICLE

Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease Jing Chen1,2,3*, L. Lee Hamm1,2, Emile R. Mohler4, Alhakam Hudaihed1, Robin Arora1, Chung-Shiuan Chen3, Yanxi Liu3, Grace Browne3, Katherine T. Mills3, Myra A. Kleinpeter1, Eric E. Simon1, Nader Rifai5, Michael J. Klag6, Jiang He1,2,3 1 Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America, 2 Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana, United States of America, 3 Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America, 4 Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 5 Department of Pathology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 6 The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America * [email protected] OPEN ACCESS Citation: Chen J, Hamm LL, Mohler ER, Hudaihed A, Arora R, Chen C-S, et al. (2015) Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease. PLoS ONE 10(7): e0132047. doi:10.1371/journal.pone.0132047 Editor: Leighton R James, University of Florida, UNITED STATES Received: December 30, 2014 Accepted: June 9, 2015 Published: July 1, 2015 Copyright: © 2015 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Due to ethical restrictions, as mandated by the Tulane University Institute Review Board, data are available upon request. Interested researchers may contact Jing Chen, MD, MSc, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112; [email protected] for access to sensitive data. Funding: This study was supported by the grants (P20-RR017659, P20RR017659-08S2 and P30GM103337) from the National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD. The funders had no role in study

Abstract The interrelationship of multiple endothelial biomarkers and chronic kidney disease (CKD) has not been well studied. We measured asymmetric dimethylarginine (ADMA), L-arginine, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule1 (sVCAM-1), soluble E-selectin (sE-selectin), von Willebrand factor (vWF), flow-mediated dilation (FMD), and nitroglycerin-induced dilation (NID) in 201 patients with CKD and 201 community-based controls without CKD. Multivariable analyses were used to examine the interrelationship of endothelial biomarkers with CKD. The multivariable-adjusted medians (interquartile ranges) were 0.54 (0.40, 0.75) in patients with CKD vs. 0.25 (0.22, 0.27) μmol /L in controls without CKD (p

Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease.

The interrelationship of multiple endothelial biomarkers and chronic kidney disease (CKD) has not been well studied. We measured asymmetric dimethylar...
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