Int J Psychiatry Clin Pract 2014; 18: 221. © 2014 Informa Healthcare ISSN 1365-1501 print/ISSN 1471-1788 online. DOI: 10.3109/13651501.2014.972680

EDITORIAL

International Journal of Psychiatry in Clinical Practice Dear colleagues, It is my great pleasure to welcome you to the fourth issue of 2014. In our first article Kastner and Linden provide a review on the relations between patients in psychiatric and psychotherapeutic inpatient care. They concluded that a positive therapeutic milieu had beneficial effects on the patients, however few inpatient units had developed guidelines on how to facilitate and improve staff and patient interactions. Ma et al. investigated the HTR2C polymorphisms and antipsychotic-induced metabolic syndrome in schizophrenia patients. Their results support the hypothesis that HTR2C polymorphisms play a role in antipsychotic-induced metabolic disturbances. Ücok and colleagues assessed the effects of obsessivecompulsive symptoms on the quality of life in patients with schizophrenia. They concluded that obsessivecompulsive symptoms were related to a lower quality of life. Camuri et al. compared the prevalence and disability of comorbid social phobia (SP) and obsessive-compulsive disorder (OCD) in patients with panic disorder (PD) and generalized anxiety disorder (GAD). It emerged that SP and OCD comorbidities were prevalent and disabling among GAD and PD and had a negative impact on quality of life. Pallanti and colleagues evaluated the brain-derived neurotrophic factor (BDNF) and Artemin (ARTN) plasma levels in GAD patients. Their results showed an almost doubled increase in both BDNF and ARTN in GAD patients as compared to healthy controls. Turan et al. investigated the effects of electroconvulsive therapy (ECT) on plasma levels of neuroactive steroids in major depressive disorder inpatients. While ECT did not seem to influence the neuroactive steroid plasma levels, dehydroepiandrosterone and pregnenolone seemed to be associated with a decrease of depressive symptoms after ECT. Pehlivanidis and colleagues sought to determine the prevalence and clinical correlates of comorbid attention-deficit/ hyperactivity disorder (ADHD) in adult outpatients with depressive or anxiety disorders. They concluded that ADHD might go unrecognized among depressive and anxiety patients and that careful screening was required if patients reported more severe symptomatology.

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Keshavarzi et al. explored the prevalence of ADHD and mental retardation in siblings and to which extent ADHD in childhood was associated with birth order and gender as compared to healthy controls. Their results suggest that ADHD symptoms in childhood were associated with the occurrence of ADHD in siblings and male gender, but not to birth order. Sahin and colleagues compared the effects of methylphenidate treatment on leptin, ghrelin and adiponectin levels, BDNF and appetite in children and adolescents with ADHD. While leptin and BDNF were not associated with poor appetite, ghrelin and adiponectin seemed to play a role in the underlying neurobiological mechanisms of methylphenidate-related appetite. Eryilmaz et al. assessed the effects of valproate on plasma concentrations of aripiprazole in bipolar patients. The authors observed a statistically significant difference between aripiprazole monotherapy and aripiprazolevalproate combination with respect to the total ariprazole plasma levels as there was a lower ariprazole concentration during comedication with valproate. Ghassami and colleagues investigated the psychometric properties of a Persian version of the Female Sexual Distress Scale-Revised (P-FSDS-R) among healthy women. They concluded that the P-FSDS-R version was a valid and reliable tool. Rombold et al. present a short report on adjunctive lithium treatment as prevention of suicidal behavior in patients with depression and comorbid personality disorders (PD). Their findings indicate that among comorbid PD patients, lithium did not have an effect on suicidal behavior in contrast to depressive patients without comorbid PD. Mohr and Huguelet evaluated the treatment wishes of outpatients with severe mental disorders with regard to spiritual and religious issues. They concluded that for 10% of the patients spiritual and religious issues were of clinical significance and that these issues should be integrated into psychiatric treatment.

Yours sincerely, Siegfried Kasper, MD Chief Editor

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