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OPEN
received: 12 January 2016 accepted: 28 April 2016 Published: 26 May 2016
Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma Lin Lin1,2,*, Jiayi Wang1,*, Dongjuan Liu1,*, Sai Liu1, Hao Xu1, Ning Ji1, Min Zhou1, Xin Zeng1, Dunfang Zhang1, Jing Li1 & Qianming Chen1 Interleukin 37 (IL-37) has been reported to play a significant role in innate immune response and to be involved in several kinds of cancers. However, the investigation of association between IL-37 and oral mucosa carcinogenesis hasn't been clearly established. The aim of the study was to assess IL-37 expression and explore its role in oral mucosa carcinogenesis. The expression of IL-37 increased from normal control (NC) to Oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Moreover, statistically highly significant difference was present between scores of OLK with and without mild/ moderate dysplasia (P
OPEN
received: 12 January 2016 accepted: 28 April 2016 Published: 26 May 2016
Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma Lin Lin1,2,*, Jiayi Wang1,*, Dongjuan Liu1,*, Sai Liu1, Hao Xu1, Ning Ji1, Min Zhou1, Xin Zeng1, Dunfang Zhang1, Jing Li1 & Qianming Chen1 Interleukin 37 (IL-37) has been reported to play a significant role in innate immune response and to be involved in several kinds of cancers. However, the investigation of association between IL-37 and oral mucosa carcinogenesis hasn't been clearly established. The aim of the study was to assess IL-37 expression and explore its role in oral mucosa carcinogenesis. The expression of IL-37 increased from normal control (NC) to Oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Moreover, statistically highly significant difference was present between scores of OLK with and without mild/ moderate dysplasia (P
