Original Report: Patient-Oriented, Translational Research American
Journal of
Nephrology
Am J Nephrol 2014;39:427–435 DOI: 10.1159/000362743
Received: February 7, 2014 Accepted: April 3, 2014 Published online: May 10, 2014
Interdialytic Weight Gain and Cardiovascular Outcome in Incident Hemodialysis Patients Mi Jung Lee a Fa Mee Doh a Chan Ho Kim a Hyang Mo Koo a Hyung Jung Oh a Jung Tak Park a Seung Hyeok Han a Tae-Hyun Yoo a, b Yong-Lim Kim e, f Yon Su Kim c, f Chul Woo Yang d, f Nam-Ho Kim f, g Shin-Wook Kang a, b, f a Department of Internal Medicine, Yonsei University College of Medicine, b Severance Biomedical Science Institute, Brain Korea 21 PLUS, Yonsei University, c Department of Internal Medicine, Seoul National University College of Medicine, d Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, e Department of Internal Medicine, Kyungpook National University School of Medicine, f Clinical Research Center for End-Stage Renal Disease, Daegu, and g Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
Abstract Background: Interdialytic weight gain (IDWG) has been regarded as a surrogate of volume overload, but also as a marker of a better nutritional status in end-stage renal disease (ESRD) patients on hemodialysis (HD). This paradoxical meaning of IDWG requires further investigation, particularly in adverse cardiovascular outcomes. Methods: A prospective cohort of 1,013 incident HD patients from 36 HD centers of the Clinical Research Center for ESRD in Korea was included. Patients were categorized into five groups according to the IDWG%, a ratio of absolute IDWG to dry weight:
Journal of
Nephrology
Am J Nephrol 2014;39:427–435 DOI: 10.1159/000362743
Received: February 7, 2014 Accepted: April 3, 2014 Published online: May 10, 2014
Interdialytic Weight Gain and Cardiovascular Outcome in Incident Hemodialysis Patients Mi Jung Lee a Fa Mee Doh a Chan Ho Kim a Hyang Mo Koo a Hyung Jung Oh a Jung Tak Park a Seung Hyeok Han a Tae-Hyun Yoo a, b Yong-Lim Kim e, f Yon Su Kim c, f Chul Woo Yang d, f Nam-Ho Kim f, g Shin-Wook Kang a, b, f a Department of Internal Medicine, Yonsei University College of Medicine, b Severance Biomedical Science Institute, Brain Korea 21 PLUS, Yonsei University, c Department of Internal Medicine, Seoul National University College of Medicine, d Department of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, e Department of Internal Medicine, Kyungpook National University School of Medicine, f Clinical Research Center for End-Stage Renal Disease, Daegu, and g Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
Abstract Background: Interdialytic weight gain (IDWG) has been regarded as a surrogate of volume overload, but also as a marker of a better nutritional status in end-stage renal disease (ESRD) patients on hemodialysis (HD). This paradoxical meaning of IDWG requires further investigation, particularly in adverse cardiovascular outcomes. Methods: A prospective cohort of 1,013 incident HD patients from 36 HD centers of the Clinical Research Center for ESRD in Korea was included. Patients were categorized into five groups according to the IDWG%, a ratio of absolute IDWG to dry weight:
