Department of Anthropology, University of Calcutta, India
Interaction between ABO and Haptoglobin Systems in a Bengalee Population
Key Words
Abstract
ABO groups Haptoglobin groups Association Bengalee Caste Hindu population
Blood samples from 2,232 individuals of a Bengalee Caste Hindu population were investigated in an attempt to confirm the association between the ABO and haptoglobin (HP) sys tems previously found in populations of European origin. Indi ans differ from Europeans in having lower HP*1 and higher ABO*B frequencies. In spite of this, as in previous studies, a weak HP/ABO association was found with a significantly lower HP*1 allele frequency in blood group O versus other ABO groups.
Arup Ratan Bandopadhaya
Introduction
As association between ABO blood groups and the serum protein polymorphism hapto globin (HP) has been reported by many inves tigators. ABO incompatibility between parent and offspring has been advanced as an expla nation of the observed phenomenon, but stud ies have been inconclusive on this question [1-5]. Vana and Steinberg [5] suggested that ABO-HP association cannot be explained by incompatibility, but that there is an unex plained association between the two systems, like that reported between HP and GLO-1 [6], Concerning the association of HP and GLO-1,
a subsequent study [7] exhibited a negative re sult in the white population of Victoria, Aus tralia. The Indian population in general differs from Europeans in their relatively high fre quencies of ABO*B, usually exceeding those of ABO*A. The Bengalee population in the present study has the allele frequen cies ABO*A- 0.1860, ABO*B- 0.2550 and ABO*0- 0.5590 [8], whereas the English, for example, have the frequencies ABO* A 0.2575, ABO*B- 0.1010 and A BO*0- 0.6621 [9], The frequency of HP*1 is very low in India com pared to those in European populations [10]. The Bengalee population has HP*1 frequen-
A rup Ralan B andopadhaya D epartm ent o f Anthropology University of Calcutta 35, Ballygangc C ircular R oad C alcutta 7090 19 (India)
Interaction between ABO and haptoglobin systems in a Bengalee population.
Blood samples from 2,232 individuals of a Bengalee Caste Hindu population were investigated in an attempt to confirm the association between the ABO a...