S h o r t C o m m u n ic a tio n

Department of Anthropology, University of Calcutta, India

Interaction between ABO and Haptoglobin Systems in a Bengalee Population

Key Words

Abstract

ABO groups Haptoglobin groups Association Bengalee Caste Hindu population

Blood samples from 2,232 individuals of a Bengalee Caste Hindu population were investigated in an attempt to confirm the association between the ABO and haptoglobin (HP) sys­ tems previously found in populations of European origin. Indi­ ans differ from Europeans in having lower HP*1 and higher ABO*B frequencies. In spite of this, as in previous studies, a weak HP/ABO association was found with a significantly lower HP*1 allele frequency in blood group O versus other ABO groups.

Arup Ratan Bandopadhaya

Introduction

As association between ABO blood groups and the serum protein polymorphism hapto­ globin (HP) has been reported by many inves­ tigators. ABO incompatibility between parent and offspring has been advanced as an expla­ nation of the observed phenomenon, but stud­ ies have been inconclusive on this question [1-5]. Vana and Steinberg [5] suggested that ABO-HP association cannot be explained by incompatibility, but that there is an unex­ plained association between the two systems, like that reported between HP and GLO-1 [6], Concerning the association of HP and GLO-1,

a subsequent study [7] exhibited a negative re­ sult in the white population of Victoria, Aus­ tralia. The Indian population in general differs from Europeans in their relatively high fre­ quencies of ABO*B, usually exceeding those of ABO*A. The Bengalee population in the present study has the allele frequen­ cies ABO*A- 0.1860, ABO*B- 0.2550 and ABO*0- 0.5590 [8], whereas the English, for example, have the frequencies ABO* A 0.2575, ABO*B- 0.1010 and A BO*0- 0.6621 [9], The frequency of HP*1 is very low in India com­ pared to those in European populations [10]. The Bengalee population has HP*1 frequen-

A rup Ralan B andopadhaya D epartm ent o f Anthropology University of Calcutta 35, Ballygangc C ircular R oad C alcutta 7090 19 (India)

© 1992 S. Karger A G, Basel (XK) 1-5652/92/ 0423-0201 S 2.75/0

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Hum Hcrcd 1992;42:201-203

Table 1. Joint phenotype distribution of ABO and HP in the Bengalee caste population HP phenotypes

ABO phenotypes A

Total B

O

AB

obs.

exp.

obs.

exp.

obs.

exp.

obs.

exp.

1-1 2-1 2-2

11 142 316

12.0 125.9 331.1

24 222 595

21.5 225.7 593.8

17 187 562

19.6 205.6 540.8

5 48 103

4.0 41.9 110.1

Total

469

841

766

156

57 599 1.576 2,232

X2 = 7.64: 6 d.f.; p

Interaction between ABO and haptoglobin systems in a Bengalee population.

Blood samples from 2,232 individuals of a Bengalee Caste Hindu population were investigated in an attempt to confirm the association between the ABO a...
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