CLIN CARE/EDUCATION/NUTRITION/PSYCHOSOCIAL

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Diabetes Care Volume 37, June 2014

Intensive Versus Intermediate Glucose Control in Surgical Intensive Care Unit Patients

Takehiro Okabayashi,1,2 Yasuo Shima,2 Tatsuaki Sumiyoshi,2 Akihito Kozuki,2 Teppei Tokumaru,2 Tasuo Iiyama,3 Takeki Sugimoto,1 Michiya Kobayashi,1 Masataka Yokoyama,4 and Kazuhiro Hanazaki1

Diabetes Care 2014;37:1516–1524 | DOI: 10.2337/dc13-1771

OBJECTIVE

The optimal perioperative blood glucose range to improve surgical site infection (SSI) in surgical intensive care unit (ICU) patients remains unclear. We sought to determine whether the incidence of SSI is reduced by perioperative intensive insulin therapy (IT). RESEARCH DESIGN AND METHODS

Patients were randomly assigned to receive perioperative intensive IT, with a target blood glucose range of 4.4–6.1 mmol/L, or intermediate IT, with a target blood glucose range of 7.7–10.0 mmol/L in the surgical ICU. We defined the primary end point as the incidence of SSI. RESULTS

Study participants were randomly assigned to glucose control with one of two target ranges: for 225 patients in the intermediate IT group or for 222 patients in the intensive IT group, respectively. No patients in either group became hypoglycemic (

Intensive versus intermediate glucose control in surgical intensive care unit patients.

The optimal perioperative blood glucose range to improve surgical site infection (SSI) in surgical intensive care unit (ICU) patients remains unclear...
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