0021-972x/92/7403-0539$03.00/0 Journal of Clinical Endocrinology and Metabolism Copyright 0 1992 by The Endocrine Society
Insulin-Like Growth Essential for Ovarian Evidence from IGF-I
Vol. 74, No. 3
Printed
in U.S.A.
Factor-I (IGF-I) May not Be Follicular Development: Deficiency*
JEHOSHUA DOR, IZHAR BEN-SHLOMO, BRUNO CLARA PARIENTE, DAVID LEVRAN, AVRAHAM MARKU SEPPALA, AND SHLOMO MASHIACH
LUNENFELD, KARASIK,
Department of Obstetrics and Gynecology (J.D., LB.-S., D.L., SM.) and the Institute for Endocrinology (B.L., C.P., A.K.), Sheba Medical Center, Tel Hashomer; and the Suckler School of Medicine, Tel Aviv University (B.L., C.P., A.K.), Tel Aviv, Israel; and Department I of Obstetrics and Gynecology, University Central Hospital (M.S.), Helsinki, Finland
ABSTRACT. Insulin-like growth factor-I (IGF-I) stimulates growth and differentiation in follicular granulosa cells (GC). To examine whether this effect is prerequisite to human folliculogenesis, a patient with Laron-type dwarfism (IGF-I deficiency secondary to GH receptor abnormality) was examined while undergoing in vitro fertilization treatment. Despite low levels of IGF-I in serum and follicular fluid (~3 and
Insulin-Like Growth Essential for Ovarian Evidence from IGF-I
Vol. 74, No. 3
Printed
in U.S.A.
Factor-I (IGF-I) May not Be Follicular Development: Deficiency*
JEHOSHUA DOR, IZHAR BEN-SHLOMO, BRUNO CLARA PARIENTE, DAVID LEVRAN, AVRAHAM MARKU SEPPALA, AND SHLOMO MASHIACH
LUNENFELD, KARASIK,
Department of Obstetrics and Gynecology (J.D., LB.-S., D.L., SM.) and the Institute for Endocrinology (B.L., C.P., A.K.), Sheba Medical Center, Tel Hashomer; and the Suckler School of Medicine, Tel Aviv University (B.L., C.P., A.K.), Tel Aviv, Israel; and Department I of Obstetrics and Gynecology, University Central Hospital (M.S.), Helsinki, Finland
ABSTRACT. Insulin-like growth factor-I (IGF-I) stimulates growth and differentiation in follicular granulosa cells (GC). To examine whether this effect is prerequisite to human folliculogenesis, a patient with Laron-type dwarfism (IGF-I deficiency secondary to GH receptor abnormality) was examined while undergoing in vitro fertilization treatment. Despite low levels of IGF-I in serum and follicular fluid (~3 and
