EXPERIMENTAL AND THERAPEUTIC MEDICINE 12: 1525-1530, 2016
Inhibitory effect of α-solanine on esophageal carcinoma in vitro LEI WANG1, QIAN‑QIAN SUN3, SHI‑JIE ZHANG2, YU‑WEN DU3, YUAN‑YUAN WANG3, WEN‑QIAO ZANG3, XIAO‑NAN CHEN3 and GUO‑QIANG ZHAO3 Departments of 1Emergency and 2Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052; 3College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China Received June 11, 2015; Accepted June 7, 2016 DOI: 10.3892/etm.2016.3500 Abstract. α‑solanine, a bioactive component and one of the major steroidal glycoalkaloids in potatoes, has been observed to inhibit growth and induce apoptosis in cancer cells. However, the antitumor efficacy of α‑solanine on esophageal carcinoma has yet to be fully elucidated. In the present study, the antitumor efficacy of α‑solanine against human esophageal carcinoma cells was investigated. It was determined that α‑solanine inhibited the growth and proliferation of human esophageal EC9706 and Eca109 cancer cells in a dose‑dependent manner, as well as the cell migration and invasion. In addition, the apoptotic rate was increased in the cancer cells treated with α‑solanine in a dose‑dependent manner, compared with that of the control group (P
Inhibitory effect of α-solanine on esophageal carcinoma in vitro LEI WANG1, QIAN‑QIAN SUN3, SHI‑JIE ZHANG2, YU‑WEN DU3, YUAN‑YUAN WANG3, WEN‑QIAO ZANG3, XIAO‑NAN CHEN3 and GUO‑QIANG ZHAO3 Departments of 1Emergency and 2Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052; 3College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China Received June 11, 2015; Accepted June 7, 2016 DOI: 10.3892/etm.2016.3500 Abstract. α‑solanine, a bioactive component and one of the major steroidal glycoalkaloids in potatoes, has been observed to inhibit growth and induce apoptosis in cancer cells. However, the antitumor efficacy of α‑solanine on esophageal carcinoma has yet to be fully elucidated. In the present study, the antitumor efficacy of α‑solanine against human esophageal carcinoma cells was investigated. It was determined that α‑solanine inhibited the growth and proliferation of human esophageal EC9706 and Eca109 cancer cells in a dose‑dependent manner, as well as the cell migration and invasion. In addition, the apoptotic rate was increased in the cancer cells treated with α‑solanine in a dose‑dependent manner, compared with that of the control group (P
