THROMBOSIS RESEARCH 64; 91-loo,1991 0049-3848/91 $3.00 + .OO Printed in the USA. Copyright (c) 1991 Pergamon Press plc. All rights reserved.
PLATELET AQGREGJLTIOH BY SONS FLAVOIWOIDS
Shu-Huey Tseng, Dun-Chang Ko, Peng-Nien Ko*, and Che-Ming Teng* Department of Pharmacology, Taipei Medical College and *Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan.
in revised form 13.8.1991
by Editor A. Takada)
The inhibitory effects of five flavonoids on the aggregation and studied. These flavonoids platelets were secretion of inhibited markedly platelet aggregation and ATP release of rabbit platelets induced by arachidonic acid or collagen, and slightly factor. ADP-induced platelet thoee by platelet-activating fisetin and myricetin, aggregation was also suppressed by The acid-induced plate'let quercetin. IC50 on arachidonic kaempferol, 20 j.M; guercetin, aggregation was: fisetin, 22 PM; formations 13 pM; morin, 150 PMcIC50